A5114400787- Immune cells in cancer
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Fibroblast Growth Factor Research
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Meat and Animal Product Quality
- Heat shock proteins research
- Chemokine receptors and signaling
- MicroRNA in disease regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Sirtuins and Resveratrol in Medicine
- Pluripotent Stem Cells Research
- Muscle Physiology and Disorders
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Amyotrophic Lateral Sclerosis Research
- Retinoids in leukemia and cellular processes
- Bioactive Natural Diterpenoids Research
- Vibrio bacteria research studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
Dong-A University
2019-2025
Korea Research Institute of Bioscience and Biotechnology
2014-2019
Washington University in St. Louis
2013
Korea University
2009-2011
Chonnam National University
2006-2010
Yonsei University Dental Hospital
2009
The principle factors underlying gastric cancer (GC) development and outcomes are not well characterized resulting in a paucity of validated therapeutic targets. To identify potential molecular targets, we analyze gene expression data from GC patients the nuclear receptor ESRRG as candidate tumor suppressor. is decreased predictor poor clinical outcome. Importantly, suppresses cell growth tumorigenesis. Gene profiling suggests that antagonizes Wnt signaling via suppression TCF4/LEF1 binding...
Background: Natural Killer (NK) cell-based immunotherapy used to treat cancer requires the adoptive transfer of a large number activated NK cells. Here, we report new effective method expand human cells ex vivo using K562 genetically engineered (GE) express OX40 ligand (K562-OX40L) in combination with short exposure soluble IL-21. In addition, describe possible mechanism cell expansion through receptor-OX40 axis which is dependent on homotypic interaction. Methods: K562-OX40L were generated...
ErbB3 is markedly overexpressed in breast cancer cells and associated with resistance metastasis. Additionally, expression levels are positively correlated low densities of tumor-infiltrating lymphocytes, a marker poor prognosis. Consequently, promising therapeutic target for immunotherapy. Here, we report the generation ErbB3-targeted chimeric antigen receptor (CAR)-modified natural killer (NK) by transducing cord blood-derived primary NK using vsv-g envelope-pseudotyped lentiviral vectors....
Myeloid-derived suppressor cells (MDSCs) favor tumor promotion, mainly by suppressing antitumor T cell responses in many cancers. Although the mechanism of inhibition is established, pathways leading to MDSC accumulation bone marrow and secondary lymphoid organs tumor-bearing hosts remain unclear. We demonstrate that down-regulation PLCγ2 signaling MDSCs responsible for their aberrant expansion during progression. PLCγ2−/− show stronger immune-suppressive activity against CD8+ than WT...
Progranulin (PGRN) is a cysteine-rich secreted protein expressed in endothelial cells, immune neurons, and adipocytes. It was first identified for its growth factor-like properties, being implicated tissue remodeling, development, inflammation, homeostasis. However, these findings are controversial, the role of PGRN liver disease remains unknown. In current study, we examined effect two different models chronic disease, methionine-choline-deficient diet (MCD)-induced non-alcoholic...
Infection with the human pathogen Vibrio vulnificus leads to generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In present study, we employed mutant V. strains identify an essential virulence factor responsible for this ROS generation. We found that repeats-in-toxin A1 (RtxA1) expressed by acts Nox1 induce significant intestine epithelial cells, which ultimately results cell death. Furthermore, RtxA1 modulates small GTPase Rac2, is known play important role...
Reactive oxygen species (ROS) actively participate in microglia-mediated pathogenesis as pro-inflammatory molecules. However, little is known about the involvement of specific antioxidants maintaining microglial oxidative balance. We demonstrate that peroxiredoxin (Prx) 5 expression up-regulated by lipopolysaccharide (LPS) through activation ROS-sensitive signaling pathway and involved attenuation both nitric oxide (NO) generation. Unlike stimulation insults with paraquat hydrogen peroxide,...
// Jinhoi Song 1, 2, * , Jaemin Lee Jinsil Kim Seongyea Jo 1 Yeon Jeong 3 Ji Eun Baek Eun-Soo Kwon Kwang-Pyo Siyoung Yang Ki-Sun Dong-Uk Tae Heung Kang 4 Yun-Yong Park 5 Suhwan Chang 6 Hee Jun Cho 7 Cheol 8 Sang Seok Koh Seokho Aging Research Institute, Korea Institute of Bioscience and Biotechnology, Daejeon, Republic 2 Department Biomolecular Science, University Science Technology, Biological Sciences, Dong-A University, Busan, Immunology, School Medicine, Konkuk Seoul, Biomedical Sciences...
The oncogenic role of microRNA-155 (miR-155) in leukemia is well established but its other cancers, especially breast cancer, gradually emerging. In this study we examined the effect mir-155 loss a well-characterized spontaneous cancer mouse model where Brca1 and Trp53 are deleted by K14-Cre. miR-155 known to be up-regulated BRCA1-deficient tumors. Surprisingly, complete (miR-155ko/ko) did not alter tumor free survival mutant mice. However, found increased infiltration myeloid derived...
CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently showed that has an important role progression and metastasis of Although secretion affects tumor cells, how it promotes tumorigenesis context microenvironment largely unknown. Here we identified novel as potent endothelial activator angiogenesis by recruiting bone marrow-derived cells to...
Kahweol, a diterpene molecule, has antiproliferative effects on several types of human cancer cells, but whether it apoptotic effect in non-small cell lung (NSCLC) is not known. To explore this possibility, we incubated cells from two NSCLC lines, NCI-H358 and NCI‑H1299, with different concentrations kahweol used the MTS assay, DAPI staining, propidium iodide Annexin V immunocytochemical test, western blot analysis to characterize molecule signaling pathway underlying its effects. The...
Dendritic cell (DC)-based vaccines have become a promising modality in cancer immunotherapy. However, their ability to initiate tumor antigen-specific T immunity is limited various negative-feedback mechanisms. The rapid down-regulation of chemokines, such as the interferon inducible protein 10 kDa (IP-10), which chemoattracts activated CD8+ cells, would represent regulation. Therefore, we attempted improve DC vaccine potency by introducing IP-10 gene retrovirally aiming replenish...
Interleukin-1β (IL-1β) is a prominent pro-inflammatory cytokine that implicated in variety of autoimmune diseases and plays an important role host defense against infections. IL-1β activity increases with its increasing binding capacity to IL-1 receptors (IL-1Rs). Thus, numerous studies have targeted the discovery molecules modulating interactions between IL-1R1. We conducted IL-1R1 structure-based virtual screening identify small could alter activity, using silico...
Adipose tissue in the loin muscle area of beef cattle as a marbling factor is directly associated with quality. To elucidate whether properties proteins involved depot specific adipose were sex-dependent, we analyzed protein expression intramuscular (IMAT) and omental (OMAT) from Hanwoo cows, steers, bulls Korean native by liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic analysis, quantitative polymerase chain reaction (PCR) western blot analysis. Two different...
Meat quality is a complex trait influenced by many factors, including genetics, nutrition, feeding environment, animal handling, and their interactions. To elucidate relevant factors affecting pork associated with oxidative stress muscle development, we analyzed protein expression in high longissimus dorsi muscles (HQLD) low (LQLD) from Duroc pigs liquid chromatographytandem mass spectrometry (LC-MS/MS)-based proteomic analysis. Between HQLD (n = 20) LQLD pigs, 24 differentially expressed...
Abstract Peroxiredoxin II knockout (Prdx −/− ) mice had a spontaneous phenotype of hemolytic anemia. In this study, we found that Ter‐119 + CD71 cells increased in Prdx bone marrow (BM) at 8 weeks age. We examined the differential expression profiles to (BMCs) between +/+ and using cDNA microarray. identified 136 candidates were differentially expressed greater twofold increase or decrease than EPO receptor. focused on up‐regulated NBPs during erythropoietic differentiation. According...
Abstract NK receptor 2B4 belongs to the signaling lymphocyte activation molecule (SLAM) family and has been shown modulate cell responses. Previously, we others have found that became expressed on effector, not naive, CD8+ T cells regulated their proliferation in vitro. However, role of Ag-specific responses vivo remains elusive. To address this, investigated effector memory generation using 2B4-deficient mice. Upon primary OVA-Vaccinia virus infection 2B4-/- mice, observed significantly...
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<p>PDF file - 207KB</p>
<div>Abstract<p>Identifying immune escape mechanisms used by tumors may define strategies to sensitize them immunotherapies which they are otherwise resistant. In this study, we show that the antiapoptotic gene <i>API5</i> acts as an in rendering resistant apoptosis triggered tumor antigen-specific T cells. Its RNAi-mediated silencing cells expressing high levels of API5 restored sensitivity. Conversely, introducing into API5<sup>low</sup> conferred...
<div>Abstract<p>Identifying immune escape mechanisms used by tumors may define strategies to sensitize them immunotherapies which they are otherwise resistant. In this study, we show that the antiapoptotic gene <i>API5</i> acts as an in rendering resistant apoptosis triggered tumor antigen-specific T cells. Its RNAi-mediated silencing cells expressing high levels of API5 restored sensitivity. Conversely, introducing into API5<sup>low</sup> conferred...