A5044078412- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Hemoglobinopathies and Related Disorders
- Genomic variations and chromosomal abnormalities
- Semiconductor materials and devices
- Cardiac Valve Diseases and Treatments
- Epigenetics and DNA Methylation
- Venous Thromboembolism Diagnosis and Management
- Hematological disorders and diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- Microbial Inactivation Methods
- Peripheral Artery Disease Management
- Blood disorders and treatments
- Bioinformatics and Genomic Networks
- Topic Modeling
- Electron and X-Ray Spectroscopy Techniques
- Genomics and Rare Diseases
- Artificial Intelligence in Healthcare and Education
- COVID-19 and healthcare impacts
- Genetic and phenotypic traits in livestock
- Occupational and environmental lung diseases
- Body Composition Measurement Techniques
Vanderbilt University Medical Center
2023-2025
Vanderbilt University
2023-2025
Stanford University
2019-2023
Palo Alto University
2021
Mayo Clinic Hospital
2018-2019
Bioengineering Center
2019
Mayo Clinic in Florida
2017-2018
WinnMed
2018
Mayo Clinic in Arizona
2018
Banner - University Medical Center Tucson
2016-2017
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence mLOY associated with altered blood cell counts and increased risk Alzheimer disease, solid tumors, other age-related diseases. We sought to gain a better understanding genetic drivers phenotypes through analyses whole-genome sequencing (WGS) large set genetically diverse males from Trans-Omics for Precision Medicine (TOPMed) program. show that haplotype-based calling methods can be...
Evidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesised a significant decrease the percentage blood volume vessels cross-sectional area between 1.25 5 mm
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants clonal expansion remain poorly understood. We performed sequencing at >4,000x depth coverage for CHIP mutations in 6,986 postmenopausal women from Women’s Health Initiative two timepoints approximately 15 years apart. Among 3,685 detected baseline (VAF ≥ 0.5%), 50% progressed to 2%) follow-up. confirmed that highly dependent on initial clone size...
To develop an algorithm using routine clinical laboratory measurements to identify people at risk for systematic underestimation of glycated hemoglobin (HbA1c) due p.Val68Met glucose-6-phosphate dehydrogenase (G6PD) deficiency. We analyzed 122,307 participants self-identified Black race across four large cohorts with blood glucose, HbA1c, and red cell distribution width from a single draw. In UK Biobank, we used recursive partitioning criteria possible likely G6PD validated the in NIH All...
Abstract Mosaic chromosomal alterations of the autosomes (aut-mCAs) are large structural somatic mutations which cause clonal hematopoiesis and increase cancer risk. Here, we detected aut-mCAs in 1,011,269 participants across four biobanks. Through integrative analysis minimum critical region inherited genetic variation, found that proto-oncogenes exclusively drive gains, tumor suppressors losses, copy-neutral events can be driven by either. We identified three novel risk loci CHI3L2, HLA...
Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it rarely progresses overt malignancy. Population variation the growth rate potential of mutant clones suggests presence genetic factors protecting against CH, but these remain largely undefined. Here, we identify a non-coding regulatory variant, rs17834140-T, significantly protects myeloid...
Abstract Small particulate matter air pollution (PM 2.5 ) is a recognized driver of non-small cell lung cancer (NSCLC) among non-smoking individuals. Inhaled PM recruits pro-inflammatory macrophages to the air-lung interface, which promotes malignant epithelial growth and progression overt cancer. We sought determine whether clonal hematopoiesis indeterminate potential (CHIP), common age-related condition characterized by hyperinflammatory macrophages, exacerbates -associated NSCLC in...
Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in hematopoietic stem cell that results clonal expansion. These driver mutations can be single nucleotide variants cancer genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors influence variations mCA fitness and ultimately result different expansion rates are not well understood. We used Passenger-Approximated Expansion Rate (PACER) method to estimate...
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence mLOY associated with altered blood cell counts and increased risk Alzheimer's disease, solid tumors, other age-related diseases. We sought to gain a better understanding genetic drivers phenotypes through analyses whole genome sequencing large set genetically diverse males from Trans-Omics for Precision Medicine (TOPMed) program. This approach enabled us identify differences...
Clonal hematopoiesis of indeterminate potential (CHIP) is an asymptomatic condition associated with elevated risk for myeloid neoplasms (MN). Patients CHIP and cytopenia are at greater MN. Quantifying the incidence identifying factors among patients critical improving clinical management. We analyzed sequencing data from 805,249 participants in NIH All Us Research Program (AoU), Vanderbilt's BioVU repository, UK Biobank (UKB). Genetic mutations, laboratory values, MN diagnoses were included...
Not available.
Genotype, particularly Ras status, greatly affects prognosis and treatment of liver metastasis in colon cancer patients. This pilot aimed to apply word frequency analysis a naive Bayes classifier on radiology reports extract distinguishing imaging descriptors wild-type patients those with v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. In this institutional-review-board-approved study, we compiled SNaPshot mutation dataset from 457 adenocarcinoma From cohort patients,...
This purpose of the study was to evaluate TAVR outcomes at low, intermediate and high volume institutions.For care complex patients, volume-outcome effect is well described. The initial US experience limited a few centers excellence. impact institutional on after has not been systematically studied.Within Banner Health system, performed 3 institutions-a low volume, an institution. 181 consecutive patients undergoing within these institutions were cohort. To adjust for bias confounders...
Acute limb ischemia (ALI), a subclass of critical ischemia, is medical emergency. The cause ALI usually thrombotic or embolic in nature, and the specific etiology often dictates appropriate therapy. While diagnosis clinical with common presenting symptoms, advances ultrasound, computed tomography, magnetic resonance technology have impacted subsequent In ALI, time to revascularization tomography angiography (CTA) provides highly sensitive technique for rapidly identifying occlusions...