A5102715500- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Fungal Biology and Applications
- Microbial Metabolism and Applications
- GaN-based semiconductor devices and materials
- Marine Sponges and Natural Products
- High Altitude and Hypoxia
- Microbial Metabolic Engineering and Bioproduction
- Ga2O3 and related materials
- Plant Pathogens and Fungal Diseases
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Metal and Thin Film Mechanics
- Semiconductor materials and devices
- Respiratory Support and Mechanisms
- Plant-Microbe Interactions and Immunity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV Research and Treatment
- Photosynthetic Processes and Mechanisms
- Plant biochemistry and biosynthesis
- Mesenchymal stem cell research
- Nosocomial Infections in ICU
- Cardiovascular and Diving-Related Complications
Jiangxi Agricultural University
2024
Shanghai Jiao Tong University
2011-2020
China International Science and Technology Cooperation
2020
Children's Hospital of Chongqing Medical University
2020
Chongqing Medical University
2020
Southern Medical University
2017-2019
Zhujiang Hospital
2017-2019
Nanjing University
2017-2019
Institute of Hematology & Blood Diseases Hospital
2018-2019
East China Normal University
2018
Acinetobacter baumannii resistance to carbapenem antibiotics is a serious clinical challenge. As newly developed technology, silver nanoparticles (AgNPs) show some excellent characteristics compared older treatments, and are candidate for combating A. infection. However, its mechanism of action remains unclear. In this study, we combined AgNPs with treat carbapenem-resistant (aba1604). Our results showed that single completely inhibited growth at 2.5 μg/mL. AgNP treatment also synergistic...
Gut microbiota dysbiosis is closely associated with primary hepatocellular carcinoma (HCC). Recent studies have evaluated the early diagnosis of HCC through analysis gut dysbiosis. However, relationship between degree and prognosis remains unclear. Because accompanied by usually increases circulatory concentrations endotoxin other harmful bacterial substances, which further liver damage, we hypothesized that level stage cancer progression. To test this hypothesis, introduced a more...
Amycolatopsis orientalis is the type species of genus and its industrial strain HCCB10007, derived from ATCC 43491, has been used for large-scale production vital antibiotic vancomycin. However, to date, neither complete genomic sequence this nor a systemic characterization vancomycin biosynthesis cluster (vcm) reported. With only whole genome mediterranei available, additional genomes other may facilitate intra-generic comparative analysis genus. The A. HCCB10007 comprises an 8,948,591-bp...
The gate reliability of p-GaN AlGaN/GaN high electron mobility transistors with a ring-gate structure is investigated by step-stress experiments under bias, combined electroluminescence imaging and pulsed measurements. For stress (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Gstress</sub> ) from 0 to 13 V, the drain current found be stable decreases at V OFF-state increases ON-state. 31 ON-state, whereas...
Abstract Background CRISPR/Cas9 systems have been repurposed as canonical genome editing tools in a variety of species, but no application for the model strain Rhodobacter sphaeroides 2.4.1 was unveiled. Results Here we showed two kinds programmable base systems, cytosine editors (CBEs) and adenine (ABEs), generated by fusing endonuclease Cas9 variant to deaminase PmCDA1 or heterodimer TadA–TadA*, respectively. Using CBEs, were able obtain C-to-T mutation single double targets following...
Our previous study showed that the ribosomal protein L21 (RPL21) may play an important role in development and survival of pancreatic cancer. In this article, RNA interference (RNAi) experiments were performed with RPL21-specific small interfering (siRNA) to elucidate mechanism by which RPL21 controls PC PANC-1 BxPC-3 cell proliferation.In present study, PANC-1, cells, BALB/c nude mice used investigate antitumor effect proliferation apoptosis vitro vivo. The effects knockdown on...
Abstract We systematically synthesized mixed-halide hybrid perovskite CH 3 NH Pb(Br x I 1−x ) (0 ≤ 1) crystals in the full composition range by a solvothermal method. The as-synthesized retained cuboid shapes, and crystalline structure transitioned from tetragonal phase to cubic with an increasing Br-ion content. photoluminescence (PL) of exhibited continuous variation red (768 nm) green (549 volume ratio HBr (V %), corresponding bandgap 1.61 eV 2.26 eV. Moreover, changed nonlinearly as...
Pristinamycin, produced by Streptomyces pristinaespiralis, which is a streptogramin-like antibiotic consisting of two chemically unrelated components: pristinamycin I (PI) and II (PII), shows potent activity against many antibiotic-resistant pathogens. However, so far production titers are still quite low, particularly those PI. In this study, we constructed PI single component producing strain deleting the PII biosynthetic genes (snaE1 snaE2). Then, metabolic engineering approaches,...
While Highly Active Antiretroviral Therapy (HAART) has significantly decreased the mortality of human immunodeficiency virus (HIV)-infected patients, emerging drug resistance to approved HIV-1 integrase inhibitors highlights need develop new antivirals with novel mechanisms action. In this study, we screened a library microbial natural compounds from endophytic fungus Colletotrichum sp. and identified alternariol 5-O-methyl ether (AME) as compound that inhibits pre-integration steps. Time-of...
Abstract A novel phytotoxic nonenolide, (6 S ,7 R ,9 )‐6,7‐dihydroxy‐9‐propylnon‐4‐eno‐9‐lactone ( 1 ), was isolated from solid cultures of the endophytic fungus Phomopsis sp. HCCB03520, together with three known compounds, cytochalasin H 2 N 3 and epoxycytochalasin 4 ). The structures these compounds were elucidated through spectroscopic analysis, absolute configurations determined by CD spectroscopy. Phytotoxic activities – also investigated. Compound showed activity on germination radicle...