A5014014992- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer survivorship and care
- Pain Management and Opioid Use
- Cancer Treatment and Pharmacology
- Renal Diseases and Glomerulopathies
- Genetics, Aging, and Longevity in Model Organisms
- Nutritional Studies and Diet
- Cancer-related cognitive impairment studies
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Chemotherapy-induced cardiotoxicity and mitigation
- Nutrition, Genetics, and Disease
- Eicosanoids and Hypertension Pharmacology
- Musculoskeletal pain and rehabilitation
- Chronic Kidney Disease and Diabetes
- biodegradable polymer synthesis and properties
- Chromosomal and Genetic Variations
- Cancer Mechanisms and Therapy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Heart rate and cardiovascular health
- Genomic variations and chromosomal abnormalities
- Digital Mental Health Interventions
- Genomics and Rare Diseases
Bio4Dreams (Italy)
2022-2023
Servizio Sanitario Nazionale
2023
University of Milan
2011-2022
University of Parma
2019-2022
Fondazione Filarete
2015
SIB Swiss Institute of Bioinformatics
2011
The 15q24.1 locus, including CYP1A2, is associated with blood pressure (BP). CYP1A2 rs762551 C allele lower enzyme activity. metabolizes caffeine and induced by smoking. association of consumption hypertension remains controversial. We explored the effects variants activity on BP, focusing as potential mediator effects. Four observational (n = 16 719) one quasi-experimental studies 106) European adults were conducted. Outcome measures intake, polymorphisms rs762551, rs1133323 rs1378942. in...
Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile susceptibility atherosclerosis cardiovascular disease. However, the interaction between these factors remains be investigated. We performed an observational nutrigenetic study examine whether anthocyanins PON1 genetic variants can modulate biomarkers of health in Italian healthy population. recruited 443 volunteers who participated EC funded ATHENA project (AnThocyanin...
Chronic pain (CP) and its management are critical issues in the care pathway of patients with breast cancer. Considering complexity CP experience cancer, international scientific community has advocated identifying cutting-edge approaches for management. Recent advances field health technology enable adoption a novel approach to by developing integrated ecosystems mobile apps.The primary end point this pilot study is evaluate patients' usability at 3 months new digital technological...
Biobased composites with peculiar properties offer an attractive route for producing environmentally friendly materials. The reinforcement poly(butylene adipate-co-terephthalate) (PBAT), based on zein-titanium dioxide (TiO2) complex (ZTC) microparticles, is presented and used to produce composite filaments, successfully 3-dimensionally (3D) printed by fused deposition modeling (FDM). outcome of ZTC addition, ranging from 5 40 wt %, the thermo-mechanical materials was analyzed. Results reveal...
Chronic pain is one of the most common and critical long-term effects breast cancer. Digital health technologies enhance management chronic by monitoring physical psychological status supporting self-management patient treatment decisions throughout clinical pathway.
Genomic studies have identified recurrent somatic alterations in genes involved DNA methylation and post-translational histone modifications acute lymphoblastic leukemia (ALL), suggesting new opportunities for therapeutic interventions. In this study, we G9a/EHMT2 as a potential target T-ALL through the intersection of epigenome-centered shRNA chemical screens. We subsequently validated G9a with low-throughput CRISPR-Cas9-based targeting catalytic SET-domain testing inhibitors vitro, 3D,...
Considering that Aurora kinase inhibitors are currently under clinical investigation in hematologic cancers, the identification of molecular events limit response to such agents is essential for enhancing outcomes. Here, we discover a NF-κB-inducing (NIK)-c-Abl-STAT3 signaling-centered feedback loop restrains efficacy multiple myeloma. Mechanistically, demonstrate inhibition promotes NIK protein stabilization via downregulation its negative regulator TRAF2. Accumulated converts c-Abl...
The emergence of evidence pointing at diet as key risk factor for chronic diseases and gene-diet interactions elements in the interplay between an individual genetic background his/her lifestyle, pave way studies nutrigenomics. Such need integrated solution to collect, monitor analyse a large set data. In frame ATHENA, European Commission FP7 project, we developed platform, called Dietary Monitoring Solution enabling collection phenotypic, lifestyle information, linked mHealth application...
<sec> <title>BACKGROUND</title> Over 50% of newly diagnosed breast cancer patients are 65+ years old. Due to age-related factors and the presence comorbidities, these particularly vulnerable developing cardiac toxicity associated with treatments, which may lead suboptimal interventions undertreatment, resulting in poorer health outcomes, Quality Life (QoL) deterioration increased healthcare costs. Given underrepresentation elderly clinical trials increasing recognition psycho-social...
The new generation of health information standards, where the syntax and semantics content is explicitly formalized, allows for interoperability in healthcare scenarios analysis clinical research settings. Studies involving genomic data include accumulating knowledge as relationships between genotypic phenotypic well associations within worlds. Some involve results targeted at a specific disease; others are predictive nature to patient may be used by decision support applications....
<sec> <title>BACKGROUND</title> Chronic pain (CP) and its management are critical issues in the care pathway of patients with breast cancer. Considering complexity CP experience cancer, international scientific community has advocated identifying cutting-edge approaches for management. Recent advances field health technology enable adoption a novel approach to by developing integrated ecosystems mobile apps. </sec> <title>OBJECTIVE</title> The primary end point this pilot study is evaluate...
<sec> <title>BACKGROUND</title> Chronic pain is one of the most common and critical long-term effects breast cancer. Digital health technologies enhance management chronic by monitoring physical psychological status supporting self-management patient treatment decisions throughout clinical pathway. </sec> <title>OBJECTIVE</title> This pilot study aims to evaluate patients’ experiences, including usability, with a novel digital integrated ecosystem for named PainRELife. The sample included...