A5011609471- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Antibiotic Resistance in Bacteria
- Animal Nutrition and Physiology
- Vibrio bacteria research studies
- Listeria monocytogenes in Food Safety
- Veterinary medicine and infectious diseases
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Escherichia coli research studies
- Gut microbiota and health
- Animal Disease Management and Epidemiology
- Food Safety and Hygiene
- Animal Behavior and Welfare Studies
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive tract infections research
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
University of Copenhagen
2016-2025
Statens Serum Institut
2023-2024
Lithuanian University of Health Sciences
2009-2014
APEC causes a range of infections in poultry, collectively called colibacillosis, and is the leading cause mortality associated with major economic significance poultry industry. A growing number studies have suggested as an external reservoir human ExPEC, including UPEC, which reservoir. ExPEC belonging to ST95 considered one most important pathogens both humans. This study first in-depth whole-genome-based comparison E. coli investigates core genomes well accessory avian ExPEC. We...
Salmonella is an important human pathogen and poultry products constitute source of infections. This study investigated prevalence; identified serotypes based on whole genome sequence, described spatial distribution predicted risk factors that could influence the prevalence infection in commercial farms Nigeria. A cross sectional approach was employed to collect 558 pooled shoe socks dust samples from 165 North West On-farm visitation questionnaires were administered obtain information farm...
Porcine post-weaning diarrhea (PWD) has reemerged as an important topic in pig production, common control strategies based on prophylactic use of antimicrobials and zinc oxide have been deemed unsustainable. The objectives this study were to estimate the cumulative incidence porcine with different etiologies production systems weaning without antimicrobials, assess risk factors for diarrhea, impact growth rate. A cohort was conducted at two commercial indoor producers medicinal...
Disinfection of hatching eggs is essential to ensure high quality production broilers. Different protocols are followed in different hatcheries; however, only limited scientific evidence on how the disinfection procedures impact microbiome available. The aim present study was characterize and aerobic bacterial load before during subsequent steps. included a group visibly clean dirty eggs. For eggs, an initial wash chlorine performed, hereafter all were submitted two times fumigation finally...
Recently, in-feed medicinal zinc has been phased out in pig production the European Union. This makes updated knowledge about porcine post-weaning diarrhea (PWD) crucial. The objectives of present study were to investigate (i) clinical presentation PWD pigs housed Danish herds that did not use zinc, specifically prevalence and whether was associated signs dehydration or altered body temperature; (ii) which microorganism are PWD; iii) measurements fecal pH have a potential be used...
The aim of this study was to investigate the effect avoiding flock treatment on resistance levels in intestine pigs. To this, studies, each two pig herds, quantified resistant coliforms by culture method pigs treated as or individual animal treatments orally with neomycin against post-weaning diarrhea (PWD) intramuscularly amoxicillin prevent umbilical infection. Individual oral PWD did not lead a lower number proportion compared any herds under study, despite reduction incidences 32% and...
Globally, the increase in antimicrobial resistance is of great concern. In Denmark, pig sector accountable for majority usage animals. As new-born piglets are at risk developing infectious omphalitis, and many pigs treated by antimicrobials within first days life, an early accurate diagnosis disease imperative to maintain animal welfare reduce usage. The aim present study was compare histopathological microbiological findings clinically diagnosed with without omphalitis during three after...
While pathogenic types of Escherichia coli are well characterized, relatively little is known about the commensal E. flora. In current study, antimicrobial resistance in and distribution ERIC-PCR genotypes among isolates such bacteria from cattle attendants on farms Tanzania were investigated. Seventeen genomes representing different sequenced order to determine their possible importance as a reservoir for both genes virulence factors. Both human highly resistant tetracycline (40.8% 33.1%),...
Although the pig has been introduced as an advanced animal model of genital tract infections in women, almost no knowledge exists on porcine vaginal microbiota, especially barrier-raised Göttingen Minipigs. In microbiota plays a crucial role for healthy environment and fate sexually transmitted such Chlamydia trachomatis infections. Therefore, is urgently needed minipig model. The aim this study was to characterize anterior vagina by 16 s rRNA gene sequencing prepubertal mature Minipigs...
In the current study, we identified plasmids carrying antimicrobial resistance genes in draft whole genome sequences of 16 selected Salmonella enterica isolates representing six different serovars from humans Ghana. The and location genomes were predicted using a combination PlasmidFinder, ResFinder, plasmidSPAdes BLAST genomic analysis tools. Subsequently, S1-PFGE was employed for plasmid profiles. Whole sequencing confirmed presence showing multidrug phenotypically. ESBL, either blaTEM52-B...
S . Dublin causes economic losses in cattle production, and the bacterium is a public health concern. A surveillance control program has been place Denmark since 2002 with ultimate goal to eradicate from Danish herds; however, small proportion of herds have remained positive for many years. In this study, we demonstrate that persistent infection often were infected same strain years, indicating internal biosecurity be improved curb infection. Further, domestic cases humans found caused both...
Background Tanzania is one of seven countries with the highest disease burden caused by cholera in Africa. We studied evolution Vibrio cholerae O1 isolated during past three decades. Methodology/Principal findings Genome-wide analysis was performed to characterize V. responsible for Tanzanian 2015–2017 outbreak along strains causing outbreaks country The genomes were further analyzed a global context 590 seventh pandemic (7PET), as well environmental isolates from Lake Victoria. All 7PET...
Uropathogenic Escherichia coli (UPEC) UTI89 is a well-characterized strain, which has mainly been used to study UPEC virulence during urinary tract infection (UTI). However, little known on key fitness-factors growth in lab media and UTI. Here, we transposon-insertion-sequencing approach (TraDIS) reveal the essential-genes for vitro fitness-gene-sets Luria broth (LB) EZ-MOPS medium without glucose, as well human bacteriuria mouse cystitis. A total of 293 essential genes were identified set...
ABSTRACT Neomycin is the first-choice antibiotic for treatment of porcine enteritis caused by enterotoxigenic Escherichia coli . Resistance to this aminoglycoside on rise after increased use neomycin due ban zinc oxide. We identified resistance determinants and plasmid contents in a historical collection 128 neomycin-resistant clinical E. isolates from Danish pig farms. All were characterized whole-genome sequencing antimicrobial susceptibility testing, followed conjugation experiments...
This study aimed to investigate the prevalence of Campylobacter jejuni in potential contamination sources that are not regularly monitored such as free-living urban pigeons and crows, dogs, cats environmental water assess possible impact on epidemiology campylobacteriosis children using multilocus sequence typing (MLST). spp. were detected 36.2 % faecal samples birds 40.4 samples. A low was dogs cats, with 7.9 9.1 %, respectively. Further identification isolates revealed pet mostly...
Extended-spectrum β-lactamase (ESBL)-producing bacteria constitute an emerging global health issue with food products being vehicles of transmission and the aquatic environments serving as potential reservoirs. This study aimed to characterize ESBL-producing Escherichia coli in Nile perch water from Lake Victoria Tanzania. A total 180 samples 60 were screened for E. on MacConkey agar supplemented 2 μg/ml cefotaxime confirmed by bla CTX-M TEM PCR. Antimicrobial resistance was determined disk...
The Gram-negative bacterium Gallibacterium anatis is a major cause of salpingitis and peritonitis in commercial egg-layers, leading to reduced egg production increased mortality. Unfortunately, widespread multidrug resistance antigenic diversity makes it difficult control infections novel prevention strategies are urgently needed. In this study, pan-genomic reverse vaccinology (RV) approach was used identify potential vaccine candidates. Firstly, the genomes 10 selected strains were analyzed...
Abstract Background Post-weaning diarrhoea (PWD) is a multifactorial condition and the most well documented infectious cause enterotoxigenic Escherichia coli . The objective of study was to investigate possible associations between pathological manifestations pathogens in pigs with without PWD. conducted as case–control included total 173 from 9 different commercial intensive indoor production herds eastern Denmark. Results Based on clinical examination, 89 piglets PWD (cases) 84 (controls)...