A5000680729- GDF15 and Related Biomarkers
- Diabetes Treatment and Management
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Atherosclerosis and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Lipid metabolism and disorders
- Pharmacogenetics and Drug Metabolism
- Lipoproteins and Cardiovascular Health
- Nutrition, Genetics, and Disease
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Clusterin in disease pathology
- Cardiovascular Health and Risk Factors
- Genetics and Physical Performance
- Hernia repair and management
- Esophageal and GI Pathology
- Congenital Ear and Nasal Anomalies
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Genomics and Rare Diseases
- Inhalation and Respiratory Drug Delivery
University of the Philippines Manila
2016-2024
National Institutes of Health
2014-2021
Hospital Universitario La Paz
2020
Centro de Investigación Biomédica en Red
2020
Centre for Biomedical Network Research on Rare Diseases
2020
Instituto de Salud Carlos III
2020
National Heart Lung and Blood Institute
2014
University of the Philippines System
2009
Veins grafted into an arterial environment undergo a complex vascular remodeling process. Pathologic often results in stenosed or occluded conduit grafts. Understanding this process is important for improving the outcome of patients with coronary and peripheral artery disease undergoing surgical revascularization. Using vivo murine cell lineage-tracing models, we show that endothelial-derived cells contribute to neointimal formation through endothelial-to-mesenchymal transition (EndMT),...
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower risk serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several loci at once, thereby increasing publicly available data. A panel 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using NGS platform under collaboration Research Network (SEAPharm). Here, we present frequencies variants...
Hypoxia leading to stabilization of hypoxia-inducible factor 1α (HIF-1α) serves as an early upstream initiator for adipose tissue (AT) dysfunction. Monocyte-derived macrophage infiltration in AT contributes inflammation, fibrosis and obesity-related metabolic It was previously reported that myeloid cell-specific deletion Hif-1α protected against high-fat diet (HFD)-induced Prolyl hydroxylases (PHDs) are key regulators HIF-1α. We examined the effects upregulation via prolyl-hydroxylase 2 (...
Homocysteinemia is a risk factor for cardiovascular diseases. Folic acid combined with vitamins B 6 and 12 effective in lowering homocysteine levels. This randomized placebo-controlled study was designed to determine the effect of folic acid-based supplement on secondary prevention clinical events non-ST-segment elevation acute coronary syndromes. The comprised 240 patients either unstable angina or non-ST-elevation myocardial infarction previous 2 weeks who were folate group ( n = 116)...
Background Coronary artery disease (CAD) is a common complication of Type 2 diabetes mellitus (T2DM). Understanding the pathogenesis this essential in both diagnosis and management. Thus, study aimed to characterize presence CAD T2DM using molecular markers pathway analyses. Methods The sex- age-frequency matched case-control design comparing 23 unrelated adult Filipinos with T2DM-CAD controls (DM CAD). Healthy served as reference. Total RNA from peripheral blood mononuclear cells (PBMCs)...
Background Unstable angina and non-ST elevation myocardial infarction (NSTEMI) are common acute coronary events. Homocysteine is a novel risk factor for heart diseases. Together with the conventional factors, they may affect outcome of Objective This study aims to determine effect clinical factors that responsible occurrence mortality, composite nonfatal serious rehospitalization within 6 months after onset syndromes. Methods A total 124 Filipino patients were interviewed tested blood...
A common drug used for hypertension among Filipinos is beta-blockers. Variable responses to beta-blockers are observed, and genetic predisposition suggested. This study investigated the association of variants with poor response Filipinos. total 76 Filipino adult hypertensive participants on were enrolled in an unmatched case-control study. Genotyping was done using DNA from blood samples. Candidate correlated clinical data χ2 logistic regression analysis. The deletion at least one copy...
A study among Filipinos revealed that only 15% of patients with diabetes achieved glycemic control, and poor response to metformin could be one the possible reasons. Recent studies demonstrate how genetic variations influence metformin. Hence, present aimed determine variants associated metformin.Using a candidate variant approach, 195 adult Filipino participants newly diagnosed type 2 mellitus (T2DM) were enrolled in case-control study. Genomic DNA from blood samples collected. Allelic...
Abstract High blood level of low-density lipoprotein cholesterol (LDL-C) is a major risk factor for cardiovascular disease. Although genetic variants linked to high LDL-C have been studied in other populations, there no previous studies among Filipinos. This study aims determine the association candidate LDL-C. We performed an age- and sex-matched case-control that compared Filipino participants with levels (n=60) controls (n=60). DNA was extracted from samples genotyped SNPs using...
Although immunoglobulin (IgY) has therapeutic potential, extracts from conventional methods are generally parenterally incompatible. This present study aimed to design a method generate an IgY composition in vivo administration. The proposed procedure incorporated the following modifications: delipidation using carrageenan, salt precipitation sodium sulfate, desalting gel filtration, and affinity chromatography MgCl2 as disrupting agent. Furthermore, specific was generated against human...
Type 2 diabetes mellitus leads to debilitating complications that affect the quality of life many Filipinos. Genetic variability contributes 30% 70% T2DM risk. Determining genomic variants related type susceptibility can lead early detection prevent complications. However, interethnic in risk and genetic exists. This study aimed identify associated with among Filipinos using a case-control design frequency matched for age sex. A comparison was made between 66 unrelated Filipino adults 121...
Cough is a common side effect of angiotensin converting enzyme inhibitor (ACEi) therapy. The incidence ACEi-induced cough has been shown to correlate with genetic variation among different populations. This study aimed determine the association candidate polymorphisms Filipinos. Two hundred twenty (220) participants on ACEi therapy pressure-lowering in an unmatched case-control (82 cases and 138 controls). Genomic DNA samples were extracted genotyped for selected variants. variants clinical...
Abstract Background Systemic lupus erythematosus (SLE) is a complex prototypic autoimmune disease, with prevalence of 20–150 per 100,000, most commonly affecting women at child‐bearing age. Genome‐wide association studies and fine mapping candidate regions have paved the way for greater understanding SLE as disease genetic–environmental susceptibility functions genes involved. Method This study was conducted to determine selected single nucleotide polymorphisms (SNPs) from established...
Background. Low levels of high-density lipoprotein cholesterol (HDL-c) is a well-recognized risk factor in the development cardiovascular diseases. Associated gene variants for low HDL-c have already been demonstrated various populations. Such associations yet to be established among Filipinos who reportedly much higher prevalence compared other races. Objective. To determine association selected genetic and clinical factors with phenotype Filipinos. Methods. An age- sex-matched case-control...
Background Subacute sclerosing panencephalitis (SSPE) is a fatal neurodegenerative disease resulting from long-term persistence of the measles virus in brain. Host genetic factors contributing to SSPE predisposition were investigated study.
Effect of anti-CD14 mAbs or IgG2a on fMLP-triggered respiratory burst control unprimed (a) and Re-LPS primed human PML (b)
Objectives. The highly polymorphic nature of the CYP2D6 gene and its central role in metabolism commonly used drugs make it an ideal candidate for pharmacogenetic screening. This study aims to determine prevalence polymorphisms among Filipinos their association lung cancer. Method. Forty seven single nucleotide (SNPs) were genotyped from DNA samples 115 cases with cancer age- sex-matched controls. Results. Results show that 18 out 47 have significant genotypic variability (>1% at least 2...
Background: Increased blood homocysteine level is a risk factor for unstable angina and non-ST elevation myocardial infarction (NSTEMI). Studies associate levels with conventional cardiovascular factors - smoking, diabetes, hypertension, advanced age, and dyslipidemia – in subjects evidence of having coronary artery disease. Objective: This study seeks to determine the effect on patients intermediate high-risk non ST Results: Data were taken from 219 (NSTEMI) onset within the...
Abstract Background Small non-coding microRNAs (miRNAs) are increasingly recognized as key regulators of the host response to sepsis. However, molecular mechanisms implicated in role miRNAs during sepsis progression is still unclear. It hypothesized that differentially expressed genes septic patients with worse outcomes associated dysregulation miRNA expression. This study aimed identify specific miRNA-gene pairs may be development shock and renal failure Methods from serum RNA PBMCs were...
Objectives: Donnai–Barrow syndrome (DBS) or facio oculo acoustic renal (FOAR) syndrome, DBS/FOAR (MIM# 227290) is caused by mutations in the LRP2 gene 600073). Disease severity and penetrance vary greatly among patients carrying same pathogenic variant(s) single-gene variants often do not reliably predict disease phenotypes. Background: The located on chromosome 2q31.1 band encodes megalin, a multi-ligand endocytic receptor. There are less than 50 cases reported worldwide. Cases...
Triple-negative breast cancer (TNBC) is a subtype with uncertain causation except for some subtypes known genetic etiology. It associated heritability and considered genetically heterogeneous disease. TNBC poorer prognosis, more aggressive in clinical course, has treatment response, survival. This study was done to review the differentially somatically mutated genes published literature according frequency of articles cited, GO STRING analyses performed, comparison profile BRCA-UK Project...