A5102802870- Cystic Fibrosis Research Advances
- Advanced biosensing and bioanalysis techniques
- Gut microbiota and health
- Diabetes Management and Research
- Inhalation and Respiratory Drug Delivery
- Diet and metabolism studies
- Diabetes and associated disorders
- Hematopoietic Stem Cell Transplantation
- Dementia and Cognitive Impairment Research
- Genomics and Chromatin Dynamics
- Food Security and Health in Diverse Populations
- Gene expression and cancer classification
- Pancreatic and Hepatic Oncology Research
- interferon and immune responses
- Bone and Joint Diseases
- Xenotransplantation and immune response
- Neonatal Respiratory Health Research
- Nuts composition and effects
- Cell death mechanisms and regulation
- Environmental Chemistry and Analysis
- Vibrio bacteria research studies
- Lipid metabolism and disorders
- Marine and coastal ecosystems
- Eating Disorders and Behaviors
- Mesenchymal stem cell research
Istituto Giannina Gaslini
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
University of Genoa
1985-2024
Azienda Unità Sanitaria Locale Della Romagna
2024
Politecnico di Milano
2013-2019
Pennsylvania State University
2018
Gut and oral microbiota perturbations have been observed in obese adults adolescents; less is known about their influence on weight gain young children. Here we analyzed the gut of 226 two-year-olds with 16S rRNA gene sequencing. Weight length were measured at seven time points used to identify children rapid infant (a strong risk factor for childhood obesity), derive growth curves innovative Functional Data Analysis (FDA) techniques. We showed that associated negatively diversity,...
We present a new methodology, called FLAME, which simultaneously selects important predictors and produces smooth estimates in function-on-scalar linear model with large number of scalar predictors. Our framework applies quite generally by viewing the functional outcomes as elements an arbitrary real separable Hilbert space. To select while also producing parameter estimates, we utilize operators to define subspaces that are imbued certain desirable properties determined practitioner...
Abstract Motivation Genome regulatory networks have different layers and ways to modulate cellular processes, such as cell differentiation, proliferation, adaptation external stimuli. Transcription factors other chromatin-associated proteins act combinatorial protein complexes that control gene transcription. Thus, identifying functional interaction among these is a fundamental task understand the genome regulation framework. Results We developed novel approach infer interactions...
The aim of this study was to report nationwide data the prevalence disordered eating behaviors (DEBs) in adolescents with type 1 diabetes (T1D) and evaluate a multidimensional model problems, analyzing how psychopathological problems are associated DEBs metabolic control.This carried out using cross-sectional design sample 1,562 patients T1D (812 male), aged 11-19 years. Participants were recruited from multiple pediatric centers (N = 30) located northern, central, southern Italy, they...
Siderophores are organic ligands involved in dissolved iron (dFe) speciation the oceans. Their study is crucial for a better understanding of biogeochemical cycle Fe marine environment, particularly certain areas, such as Southern Ocean, where deficiency limits productivity. In this study, an analytical method proposed extraction and pre-concentration siderophores from seawater samples by solid phase (SPE) subsequent analysis high-performance liquid chromatography—electrospray...
BACKGROUND: The COVID-19 pandemic has been a complex event for children and adolescents, significantly impacting their daily activities. In this scenario, our study aims at verifying if "Space Children," an ad-hoc developed game based on interactive storytelling about the pandemic, can increase mastery reduces negative emotions COVID-19.METHODS: app Space Children sponsored spread online by email social media platforms limited time period (from May 2021 to January 2022). Before after...
Cystic fibrosis (CF) is caused by loss-of-function mutations in the CF transmembrane conductance regulator (CFTR) protein, an anion channel that regulates epithelial surface fluid secretion. The deletion of phenylalanine at position 508 (F508del) most common CFTR mutation. F508del characterized folding and trafficking defects, resulting decreased functional expression protein on plasma membrane. Several classes small molecules, named correctors, have been developed to rescue defective CFTR....
Background: The aim of the study was to determine effect an educational intervention on use trend arrows a real-time continuous glucose monitoring (rt-CGM) manage daily therapy decisions in group adolescents with type 1 diabetes attending camp. secondary evaluate variations total dose (TDD) insulin requirement. Methods: Twenty patients (15-17 years) multiple injections ( n = 8) or subcutaneous infusion 12) attended training session at beginning camp learn our algorithm for management...
Cystic fibrosis (CF) is caused by different mutations related to the cystic transmembrane regulator protein (CFTR), with F508del being most common. Pioneering development of CFTR modulators, thanks effective correctors or potentiators, more recent studies deeply encouraged administration triple combination therapeutics. However, combinations molecules interacting other proteins involved in functionality channel recently arose as a promising approach address large rescue F508del-CFTR. In this...
Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) generates local accumulations of reads on the genome ("peaks"), which correspond to specific protein-DNA interactions or chromatin modifications. Peaks are detected considering their total area above a background signal, usually neglecting shapes, instead may convey additional biological information. We present FunChIP, an R/Bioconductor package for clustering peaks according functional representation shapes: after approximating...
Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas causing progressive damage. CF caused by mutations abolishing function of CFTR, protein whose role chloride's mobilization in epithelial cells various organs. Recently therapy focused on small molecules has been chosen as main approach to contrast CF, designing synthesizing compounds acting misfolding (correctors) or defective channel gating (potentiators). Multi-drug therapies have tested with different combinations...
Aims Endoscopic biliary drainage (BD) in patients with altered anatomy is a challenging scenario, reducing the chance of clinical success compared to standard anatomy. The choice between different BD approaches still not standardized and relies on local availability expertise. Aim this study was explore approach Italian centers, including number attempts.
Abstract NOTE The biases seen in simulations of Temporal Clustering appear to be even worse real applications. While this was a novel and interesting approach, ultimately work has been discontinued. I feel the are due propagated error estimating individual level offsets based on single noisy measure, amplified by fact that high MMSE scores change very slowly therefore many estimates from near an asymptote left hand model. We continue area, with other approaches showing significantly more...
Cystic fibrosis (CF), the most common autosomal recessive fatal genetic disease in Caucasian population, is caused by mutations gene encoding cystic transmembrane conductance regulator (CFTR), an anion channel that regulates salt and water transport across a variety of secretory epithelia. Deletion phenylalanine at position 508, F508del, CF-causing mutation, destabilises CFTR protein, causing folding trafficking defects lead to dramatic reduction its functional expression. Small molecules...
It is challenging to study long-term progression of Alzheimer’s disease due short-term follow-up individuals and heterogeneity. Progression can be heterogeneous in itself, but additionally begin studies at different ages, times relative onset. Here we propose the first method – Temporal Clustering that jointly tackle these sources heterogeneity produce models progression. Data used preparation this article was obtained from PAQUID (data extracted R package lcmm), Disease Neuroimaging...
Many different amphibian skin peptides have been characterized and proven to exert various biological actions, such as wound-healing, immunomodulatory, anti-oxidant, anti-inflammatory anti-diabetic effects. In this work, the possible anti-steatotic effect of macrotympanain A1 (MA1) (FLPGLECVW), a peptide isolated from Chinese odorous frog Odorrana macrotympana, was investigated. We used well-established in vitro model hepatic steatosis, consisting lipid-loaded rat hepatoma FaO cells. model,...
Inhibitor of Apoptosis Proteins (IAPs) are validated targets for cancer therapy, and the deregulation their activities within NF-κB pathway correlates with chemoresistance events, even after treatment IAPs-antagonists in clinic (Smac-mimetics). The molecule FC2 was identified as a modulator MDA-MB-231 adenocarcinoma cells virtual screening Chembridge library against Baculoviral IAP Repeat 1 (BIR1) domain cIAP2 XIAP. An improved cytotoxic effect is observed when combined Smac-mimetics or...