A5064542720- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Infectious Diseases and Mycology
- Cancer-related Molecular Pathways
- Prostate Cancer Treatment and Research
- Sphingolipid Metabolism and Signaling
- Veterinary Oncology Research
- Peroxisome Proliferator-Activated Receptors
- Health Systems, Economic Evaluations, Quality of Life
- Latin American socio-political dynamics
- Neurofibromatosis and Schwannoma Cases
- Cancer Treatment and Pharmacology
- Pharmacological Effects and Assays
- Education and Labor Relations
- Salivary Gland Tumors Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Lipoproteins and Cardiovascular Health
- Growth Hormone and Insulin-like Growth Factors
- Economic and Financial Impacts of Cancer
- Vascular Tumors and Angiosarcomas
Hospital Perpetuo Socorro
2025
Instituto Tecnológico de Costa Rica
2024
University of the Basque Country
2017-2023
CIC bioGUNE
2017-2022
Hospital de São José
2022
Hospital Clínico Universitario Virgen de la Victoria
2016-2021
Baylor College of Medicine
2013-2020
Universitat Pompeu Fabra
2017
Municipal Institute for Medical Research
2017
Oregon Health & Science University
2016
Exosomes are small membrane vesicles released by most cell types including tumor cells. The intercellular exchange of proteins and genetic material via exosomes is a potentially effective approach for cell-to-cell communication it may perform multiple functions aiding to survival metastasis. We investigated microRNA protein profiles brain metastatic (BM) versus non-brain (non-BM) cell-derived exosomes. studied the cargo isolated from brain-tropic 70W, MDA-MB-231BR, circulating...
With the advent of OMICs technologies, both individual research groups and consortia have spear-headed characterization human samples multiple pathophysiologic origins, resulting in thousands archived genomes transcriptomes. Although a variety web tools are now available to extract information from data, their utility has been limited by capacity nonbioinformatician researchers exploit information. To address this problem, we developed CANCERTOOL, web-based interface that aims overcome major...
Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation suppresses apoptosis. It is controversial whether these increase breast cancer risk. We investigated impact several on mammary tumorigenesis initiated by retrovirus-mediated delivery either ErbB2 or HRas transgenic expression...
Abstract The PPARγ coactivator 1 alpha (PGC1α) is a prostate tumor suppressor that controls the balance between anabolism and catabolism. PGC1A downregulation in cancer causally associated with development of metastasis. Here we show transcriptional complex formed by PGC1α estrogen-related receptor (ERRα) aggressive properties cells. expression significantly decreased migration invasion various cell lines. This phenotype was consistent remarkable cytoskeletal remodeling inhibition integrin...
Gene dosage is a key defining factor to understand cancer pathogenesis and progression, which requires the development of experimental models that aid better deconstruction disease. Here, we model an aggressive form prostate show unconventional association LKB1 tumorigenesis. Whereas loss Lkb1 alone in murine epithelium was inconsequential for tumorigenesis, its combination with oncogenic insult, illustrated by Pten heterozygosity, elicited lethal metastatic cancer. Despite low frequency...
The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy Framingham-REGICOR scale, validated for Spanish population, to identify future CVD participants, who were predefined as being at high-risk PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and impact adherence Mediterranean diet on across risk categories.In a post hoc analysis, we value baseline estimated 5966...
Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as prostate cancer biomarker. This predominantly expressed in the liver, brain, pancreas, tissue, where it exhibits distinct Whereas genetic alterations GNMT have associated to risk, its causal contribution development this disease limited cell line-based studies correlative human analyses. Here we integrate studies, mouse modeling,...
Summary The influence of driver mutations on leukaemic transformation was analysed in 1747 patients with polycythaemia vera or essential thrombocythaemia. With a median follow‐up 7·2 years, 349 died and 62 progressed to acute leukaemia myelodysplastic syndrome. Taking death as competing risk, CALR genotype associated lower risk [subdistribution hazard ratio (SHR): 0·13, 95% confidence interval (CI): 0·2–0·9, P = 0·039], whereas JAK2 V617F showed borderline significance for higher (SHR: 2·05,...
The nuclear receptor PPAR-β/δ (PPARD) has essential roles in fatty acid catabolism and energy homeostasis as well cell differentiation, inflammation, metabolism. However, its contributions to tumorigenesis are uncertain have been disputed. Here, we provide evidence of tumor suppressive activity PPARD prostate cancer through a noncanonical ligand-independent pathway. was downregulated specimens. In murine epithelium, gene deletion resulted increased cellularity. Genetic modulation human lines...
// Alfredo Caro-Maldonado 1 , Laura Camacho 1,2,* Amaia Zabala-Letona 1,3,* Verónica Torrano 1,3 Sonia Fernández-Ruiz Kepa Zamacola-Bascaran Leire Arreal Lorea Valcárcel-Jiménez Natalia Martín-Martín Juana M. Flores 4 Ana R. Cortazar Patricia Zúñiga-García Arruabarrena-Aristorena Fabienne Guillaumond 5,6,7,8 Diana Cabrera Juan Falcón-Perez 1,9,10 Aransay 1,9 Antonio Gomez-Muñoz 2 Mireia Olivan 11 Morote and Arkaitz Carracedo 1,2,3,10 CIC bioGUNE, Bizkaia Technology Park, Derio, Spain...
Prostate cancer is the most frequent malignancy in European men and second worldwide. One of major oncogenic events this disease includes amplification transcription factor cMYC. Amplification oncogene chromosome 8q24 occurs concomitantly with copy number increase a subset neighboring genes regulatory elements, but their contribution to pathogenesis poorly understood. Here we show that TRIB1 among robustly upregulated coding within amplicon prostate cancer. Moreover, demonstrate...
Human inflammatory breast carcinoma (IBC) and canine mammary (IMC) are considered the most malignant types of cancer. IMC has similar characteristics to IBC; hence, been suggested as a model study human disease. To compare angiogenic angioinvasive features with non-IMC, 3 tumor xenograft models in female SCID mice were developed: IMC, comedocarcinoma, osteosarcoma. Histopathological immunohistochemical characterization both primary tumors xenografts using cellular markers pancytokeratin,...
Phosphatidic acid (PA) is a key bioactive glycerophospholipid that implicated in the regulation of vital cell functions such as growth, differentiation, and migration, involved variety pathologic processes. However, molecular mechanisms by which PA exerts its pathophysiological actions are incompletely understood. In present work, we demonstrate stimulates migration human non-small lung cancer (NSCLC) A549 adenocarcinoma cells, determined transwell assay. induced rapid phosphorylation...
Prostate cancer (PCa) is one of the most prevalent cancers in men. Androgen receptor signaling plays a major role this disease, and androgen deprivation therapy common therapeutic strategy recurrent disease. Sphingolipid metabolism central cell death, survival, resistance cancer. Ceramide kinase (CERK) catalyzes phosphorylation ceramide to 1-phosphate, which regulates various cellular functions including growth migration. Here we show that activated (AR) repressor CERK expression. We...