A5088716539- DNA Repair Mechanisms
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant Genetic and Mutation Studies
- Plant nutrient uptake and metabolism
- Plant tissue culture and regeneration
- Carcinogens and Genotoxicity Assessment
- Chromosomal and Genetic Variations
- Plant Gene Expression Analysis
- Animal and Plant Science Education
- Organic Food and Agriculture
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Light effects on plants
- Diverse Educational Innovations Studies
- Telomeres, Telomerase, and Senescence
Sustainability Institute
2020
University of California, Davis
2003-2019
Texas A&M University
2007
The histone variant H2AX is rapidly phosphorylated at the sites of DNA double-strand breaks (DSBs). This (gamma-H2AX) involved in retention repair and signaling factor complexes damage. dependency this phosphorylation on various PI3K-related protein kinases (in mammals, ataxia telangiectasia mutated Rad3-related [ATR], [ATM], DNA-PKCs) has been a subject debate; it suggested that ATM required for induction foci DSBs, whereas ATR recognition stalled replication forks. In study, using...
Summary Double‐strand break (DSB) repair pathways catalyze the rejoining of broken chromosomes and integration transforming DNAs. These processes have been well characterized in bacteria, fungi, animals. Plants are generally thought primarily to utilize a non‐homologous end joining (NHEJ) pathway DSBs integrate transgenes, as DNAs with large tracts homology chromosome integrated at random. In order test hypothesis that NHEJ is an important for plants, we isolated T‐DNA insertion mutations...
Plants are essential for human survival. Over the past three decades, work with reference plant Arabidopsis thaliana has significantly advanced biology research. One key event was sequencing of its genome 25 years ago, which fostered many subsequent research technologies and datasets. been instrumental in elucidating plant-specific aspects biology, developing tools, translating findings to crop improvement. It not only serves as a model understanding but also other fields, discoveries having...
In the absence of telomerase, telomeres undergo progressive shortening and are ultimately recruited into end-to-end chromosome fusions via non-homologous end joining (NHEJ) double-strand break repair pathway. Previously, we showed that fusion critically shortened in Arabidopsis proceeds with approximately same efficiency presence or KU70, a key component NHEJ. Here report DNA ligase IV (LIG4) is also not essential for telomere joining. We observed only modest decrease (3-fold) frequency...
Abstract Population growth and climate change will impact food security potentially exacerbate the environmental toll that agriculture has taken on our planet. These existential concerns demand a passionate, interdisciplinary, diverse community of plant science professionals is trained during 21st century. Furthermore, societal trends question importance expert knowledge highlight need to better communicate value rigorous fundamental scientific exploration. Engaging students general public...
Abstract A key remit of the NSF ‐funded “Arabidopsis Research and Training for 21 st Century” ( ART ‐21) Coordination Network has been to convene a series workshops with community members explore issues concerning research training in plant biology, including role that using Arabidopsis thaliana can play addressing those issues. first workshop focused on needs bioinformatic computational approaches biology was held 2016, recommendations from have published (Friesner et al., Plant Physiology...
The future bioinformatics needs of the Arabidopsis community as well those other scientific communities that depend on resources were discussed at a pair recent meetings held by Multinational Steering Committee and North American Committee. There are extensive tools for information storage, curation, retrieval data have been developed over years primarily through activities Information Resource, Nottingham Stock Centre, Biological Resource Center, among others. However, rapid expansion in...
Abstract The multinational Arabidopsis research community is highly collaborative and over the past thirty years these activities have been documented by Multinational Steering Committee (MASC). Here, we (a) highlight recent advances made with reference plant thaliana ; (b) provide summaries from reports submitted MASC subcommittees, projects resources associated country representatives; (c) initiate a call for ideas foci “fourth decadal roadmap,” which will advise coordinate global of community.
It has been more than 50 years since Arabidopsis (Arabidopsis thaliana) was first introduced as a model organism to understand basic processes in plant biology. A well-organized scientific community used this small reference species make numerous fundamental biology discoveries (Provart et al., 2016). Due an extremely well-annotated genome and advances high-throughput sequencing, our understanding of other become even intricate complex. Computational resources, including CyVerse,3 Araport,4...
Low linear energy transfer (LET) gamma rays and high LET HZE (high atomic weight, energy) particles act as powerful mutagens in both plants animals. DNA damage generated by is more densely clustered than that rays. To understand the genetic requirements for resistance to vs. low radiation, a series of Arabidopsis thaliana mutants were exposed either 1GeV Fe nuclei or radiation. A comparison effects on germination subsequent growth seedlings led us conclude relative biological effectiveness...
The Inter-institutional Network for Food, Agriculture and Sustainability (INFAS or the Network), initiated informally in 2008 formalized 2011, encompasses a broad group of practitioners, primarily academic institutions, who work individually on diverse range topics agricultural food system sustainability. INFAS grew from shared vision to expose challenges facing transformation agriculture our global system, including sometimes competing interests labor, producers, consumers system. From...