A5022626501- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Asthma and respiratory diseases
- Hormonal and reproductive studies
- Allergic Rhinitis and Sensitization
- Radiopharmaceutical Chemistry and Applications
- Contact Dermatitis and Allergies
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Pelvic floor disorders treatments
- Food Allergy and Anaphylaxis Research
- X-ray Diffraction in Crystallography
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Crystallization and Solubility Studies
- Cancer, Hypoxia, and Metabolism
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Advanced Radiotherapy Techniques
Kindai University
2016-2025
Kindai University Hospital
2021-2024
National Sagamihara Hospital
2013-2019
Juntendo University
2017-2019
Suita Municipal Hospital
2017-2019
Weatherford College
2019
The Kids Research Institute Australia
2014
Gunma University
2014
Hiroshima University
2008
Kurume University
2006
It is well known that the prognosis of castration-resistant prostate cancer (CRPC) poor, and several immunotherapeutic strategies have been applied to clinical trials. Research on immunotherapy has special interest for treatment CRPC years.To evaluate safety personalized peptide vaccine (PPV) its outcomes.A phase 2 randomized controlled trial PPV with low-dose dexamethasone versus alone chemotherapy-naive began in 2008. Eligible patients (prostate-specific antigen [PSA] <10 ng/ml) were human...
Objectives To explore the characteristics of patients and assess effectiveness enfortumab vedotin (EV) in those with treatment‐resistant advanced urothelial cancer a real‐world setting. Patients Methods A multicenter observational study was conducted on 103 evaluable who received EV. Outcomes were assessed by radiographic response, progression‐free survival (PFS), overall (OS), treatment‐related adverse events (trAEs). Radiographic response using Response Evaluation Criteria Solid Tumors...
ABSTRACT Background Differences in the effectiveness of second‐generation androgen receptor axis‐targeted agents (ARATs) high‐risk metastatic hormone‐sensitive prostate cancer (mHSPC) remain unclear. This study aimed to identify factors influencing efficacy ARATs patients with mHSPC and compare their long‐term effectiveness. Methods Four hundred sixty‐six treated were retrospectively recruited from our hospital affiliated hospitals Kindai Oncology Study Group Kyoto Prefectural University...
The efficacy of abiraterone acetate varies among patients with high-risk metastatic castration-sensitive prostate cancer (mCSPC). Both androgen receptor (AR) and cytokeratin 18 (CK18) are markers the luminal lineage cancer, their expression levels have been suggested to affect response deprivation therapy (ADT). This study aimed predict in mCSPC via immunohistochemical staining biopsy specimens obtained at time diagnosis. We retrospectively analyzed 44 treated combination ADT. AR CK18 were...
Trophoblast cell surface antigen 2 (Trop-2, encoded by TACSTD2) is the target protein of sacituzumab govitecan, a novel antibody-drug conjugate for locally advanced or metastatic urothelial carcinoma. However, expression status Trop-2 in upper tract carcinoma (UTUC) remains unclear. We performed immunohistochemical analysis 99 UTUC samples to evaluate patients with and analyze its association clinical outcomes. was positive 94 samples, high associated favorable progression-free survival...
Limited information is available regarding the clinical usefulness of measuring levels IgE to allergen components from house dust mites (HDMs) in diagnosis genuine HDM allergy. To evaluate diagnostic serum antibodies (Abs) Dermatophagoides pteronyssinus (DP) as a predictor immediate asthmatic response (IAR) bronchoprovocation, we studied 55 DP-sensitized patients who underwent bronchoprovocation test using crude DP extract. The Abs DP, nDer p 1, rDer 2, and 10 showed IAR (n = 41) were...
Molecular therapy targeting tumor angiogenesis has been the standard treatment for metastatic renal cell carcinoma (mRCC). However, despite their significant antitumor effects, most of patients with mRCC have not cured. Under such circumstances, anticancer immunotherapy considered a promising modality mRCC, and cancer-reactive cytotoxic T lymphocytes (CTLs) are powerful effectors among several immune cells. CTLs can be inhibited by inhibitory mechanisms, including interaction between...
Identification of sensitized allergens for patients with respiratory allergy is an important step in disease care and environmental allergen control. The Japanese archipelago belongs to various climate categories due its length from north south which transverse the subarctic subtropical south, suggesting substantial regional differences dominant allergens. However, few studies have assessed prevalence sensitization allergens.We requested three major clinical testing laboratories provide us...
It is well known that renal cell carcinoma (RCC) represents one of the most immune-responsive cancers. Although lack defined antigens in RCC has hindered more specific vaccine development, research regarding vaccination therapy been special interest for treatment than 30 years. To evaluate safety vascular endothelial growth factor receptor 1 (VEGFR1) peptide and its clinical outcomes, data from 18 metastatic (mRCC) patients treated with VEGFR1 were collected. Toxicity assessments performed....
Chronic rhinosinusitis (CRS) is classified into eosinophilic CRS (ECRS) and non-ECRS. The objectives of this study were to evaluate lower airway inflammation by measuring the fractional concentration exhaled nitric oxide (FeNO) examine effects endoscopic sinus surgery (ESS) on FeNO in patients with ECRS compared non-ECRS.CRS nasal polyps (23 22 non-ECRS) enrolled study. was diagnosed based definition proposed Japanese Epidemiological Survey Refractory Eosinophilic Rhinosinusitis (JESREC)...
What's known on the subject? and What does study add? Targeted agents with a similar or different target molecule are often used sequentially in treatment of metastatic RCC. Two tyrosine kinase inhibitors, sorafenib sunitinib, have been reported to show little cross-resistance, when sequentially. In addition, recent report showed that sunitinib rechallenge could potentially benefit selected patients. This case series shows patients once refractory regain disease control during sequential...
Synthetic double-stranded RNA poly(I:C) is a useful immune adjuvant and exhibits direct antitumor effects against several types of cancers. In this study, we elucidated the mechanisms underlying induced in poly(I:C)-transfected human renal cell carcinoma (RCC) cells. contrast to lack an effect adding poly(I:C), transfection drastically decreased RCC viability. Poly(I:C) reactive oxygen species (ROS)-dependent apoptosis cells mitochondrial membrane potential (ΔΨm). Treatment with...
An increasing number of studies in children is highlighting the importance transdermal routes exposure to food allergens through damaged skin pathogenesis allergies. However, data on this adults are limited. A few case-series has documented development allergy among kitchen workers with hand eczema after direct contact foods. To explore significance as a risk factor for allergies at epidemiological level, we performed cross-sectional web-based questionnaire survey whose exposures were...
Tungsten functional paper (TFP) is a paper-based radiation-shielding material, which lead-free and easy to cut. We developed radiation protection undergarment using TFP for prostate cancer patients treated with permanent 125I seed implantation (PSI). The aim of this study was evaluate the shielding ability respect household contacts members public. Between October 2016 April 2017, total 10 PSI were enrolled in prospective study. external exposure from each patient 1 day after measured...
Despite recent advances in the treatment for advanced prostate cancer, outcomes remain poor. This lack of efficacy has prompted development alternative strategies. In present study we investigate effects multikinase inhibitor sorafenib a genetically engineered mouse model cancer and explore rational combination with mTOR everolimus.Conditional specific PTEN-deficient knockout mice were utilized to determine pharmacodynamic chemopreventive sorafenib. was also used examine therapeutic alone or...