Domingo Palmero
A5021648205- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- HIV/AIDS drug development and treatment
- Cancer Research and Treatments
- Pharmaceutical studies and practices
- Pharmacovigilance and Adverse Drug Reactions
- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- interferon and immune responses
- Infectious Diseases and Mycology
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Blood disorders and treatments
- COVID-19 epidemiological studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Hospital Muñiz
2015-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2023
Université de Toulouse
2023
Centre National de la Recherche Scientifique
2023
Inserm
2023
Centre d’Immunologie de Marseille-Luminy
2023
Aix-Marseille Université
2023
Academia Nacional de Medicina
2023
Université Toulouse III - Paul Sabatier
2023
Universidade Federal do Rio Grande do Sul
2022
The production of guidelines for the management drug-resistant tuberculosis (TB) fits mandate World Health Organization (WHO) to support countries in reinforcement patient care. WHO commissioned external reviews summarise evidence on priority questions regarding case-finding, treatment regimens multidrug-resistant TB (MDR-TB), monitoring response MDR-TB treatment, and models A multidisciplinary expert panel used Grading Recommendations Assessment, Development Evaluation (GRADE) approach...
Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed evaluate the safety effectiveness of bedaquiline-containing regimens in a large, retrospective, observational conducted 25 centres 15 countries five continents.428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). admitted hospital for median (interquartile range (IQR)) 179 (92-280) days exposed 168...
Abstract Coronavirus disease has disrupted tuberculosis services globally. Data from 33 centers in 16 countries on 5 continents showed that attendance at was lower during the first 4 months of pandemic 2020 than for same period 2019. Resources are needed to ensure care continuity pandemic.
The World Health Organization (WHO) recommends that countries implement pharmacovigilance and collect information on active drug safety monitoring (aDSM) management of adverse events.The aim this prospective study was to evaluate the frequency severity events anti-tuberculosis (TB) drugs in a cohort consecutive TB patients treated with new (i.e. bedaquiline, delamanid) repurposed clofazimine, linezolid) drugs, based WHO aDSM project. Adverse were collected prospectively after attribution...
BACKGROUND: Increasing evidence suggests that post-TB lung disease (PTLD) causes significant morbidity and mortality. The aim of these clinical standards is to provide guidance on the assessment management PTLD implementation pulmonary rehabilitation (PR).METHODS: A panel global experts in field TB care PR was identified; 62 participated a Delphi process. 5-point Likert scale used score initial ideas for after several rounds revision document approved (with 100% agreement).RESULTS: Five were...
ABSTRACT Th1 lymphocytes are crucial in the immune response against Mycobacterium tuberculosis. Nevertheless, IFN-γ alone is not sufficient complete eradication of bacteria, suggesting that other cytokines might be required for pathogen removal. Th17 cells have been associated with M. tuberculosis infection, but role IL-17-producing human TB remains to understood. Therefore, we investigated induction and regulation IL-17 during active disease. patients were classified as High Low Responder...
The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV has been driver for drug resistance in Mycobacterium (Mtb). Here we assess impact of co-infection on emergence and transmission Mtb largest outbreak multidrug-resistant TB South America date. By combining Bayesian evolutionary analyses reconstruction networks utilizing new model optimized TB, find that does not significantly affect transmissibility...
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. aim study is to prospectively evaluate effectiveness bedaquiline (and/or delamanid)- containing regimens a large cohort consecutive TB patients treated globally. This observational, prospective based on data collected and provided by Global Tuberculosis Network (GTN) centres analysed twice year. All (including children/adolescents) with and/or delamanid...
Background Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes affected by TB COVID-19. Methods We collected from 174 centres in 31 countries on all COVID-19 between 1 March 2020 30 September 2022. Patients were followed-up until cure, death or end time. All had COVID-19; for analysis purposes, deaths attributed to TB, both. Survival was performed using Cox proportional...
Adverse effects (AE) to TB treatment cause morbidity, mortality and interruption. The aim of these clinical standards is encourage best practise for the diagnosis management AE.
Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival virulent Mtb in macrophage cell lines. We investigated the contribution to defense antigen (Mtb-Ag) cells from patients and healthy donors (HD). Patients were classified as high responders (HR) if their T produced significant IFNG Mtb-Ag; low (LR) when showed weak or no responses Mtb-Ag. The highest levels detected HD whereas lowest quantities observed...
The ability of Mycobacterium tuberculosis (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation lipid metabolism leading formation foamy macrophages (FM). Yet specific factors phenotype Mtb-infected remain unknown. Herein, we aimed address whether cytokines contribute FM context Mtb infection. Our approach is based use an acellular fraction tuberculous pleural effusions (TB-PE) a physiological source local released during We found that...
To reconstruct transmission chains of the multidrug-resistant tuberculosis Ch strain, which harbors a unique combination resistance mutations, we analyzed genomes 25 isolates from 12 patients with diagnosis during 2006-2022 in Chaco Province, Argentina. Amplification resistance, high mortality rates, and indications wider outbreak raise concerns for surveillance programs.
Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence a human genetic component. Here, we investigated association rs2275913 SNP (G → A) from IL-17A and in Argentina by case-control study. Furthermore, evaluated vitro functional relevance this during immune response host against analyzed its impact on clinical parameters disease. We found an between AA genotype...
During mycobacterial infection, macroautophagy/autophagy, a process modulated by cytokines, is essential for mounting successful host responses. Autophagy collaborates with human immune responses against Mycobacterium tuberculosis (Mt) in association specific IFNG secreted the pathogen. However, alone not sufficient to complete bacterial eradication, and other cytokines might be required. Actually, induction of Th1 Th17 are required protection Mt. Accordingly, we showed that IL17A expression...
Rationale: Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was defined as TB with resistance to rifampicin and isoniazid (multidrug-resistant [MDR-TB]), any fluoroquinolone (FQ), second-line injectable drug (SLID). In 2019, the World Health Organization issued new recommendations for treating patients TB, substantially limiting role of SLIDs in MDR-TB treatment thus putting definition XDR-TB into question. Objectives: To propose an up-to-date XDR-TB. Methods: We used a large...