A5003107621- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Respiratory and Cough-Related Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Inhalation and Respiratory Drug Delivery
- Mycobacterium research and diagnosis
- Chronic Disease Management Strategies
- Acute Ischemic Stroke Management
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Renal function and acid-base balance
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and Mental Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heart Failure Treatment and Management
- Psychosomatic Disorders and Their Treatments
- Quinazolinone synthesis and applications
UNSW Sydney
1998-2025
St Vincent's Hospital Sydney
2013-2025
St Vincent's Hospital
2018-2024
St. Vincent's Hospital
2024
Saint Vincent's Catholic Medical Center
2024
St. Vincent's Birmingham
2024
EsSALUD
2017-2024
Thoracic Surgery Foundation
2024
Thoracic Society of Australia and New Zealand
2024
St Vincent's Clinic
2020-2023
ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and psycho-social impairment, but these consequences have been largely neglected. The 1 st International Post-Tuberculosis Symposium (Stellenbosch, South Africa) was held to discuss priorities gaps in addressing this issue. A barrier progress has varied terminology nomenclature, so Delphi process used achieve consensus on definitions. Lack of sufficient evidence hampered definitive recommendations most domains,...
Many individuals who survive tuberculosis disease face ongoing disability and elevated mortality risks. However, the impact of post-tuberculosis sequelae is generally omitted from policy analyses burden estimates. We therefore estimated global tuberculosis, inclusive morbidity mortality.We constructed a hypothetical cohort developing in 2019, including pulmonary extrapulmonary disease. simulated lifetime health outcomes for this cohort, stratified by country, age, sex, HIV status, treatment...
BACKGROUND: Increasing evidence suggests that post-TB lung disease (PTLD) causes significant morbidity and mortality. The aim of these clinical standards is to provide guidance on the assessment management PTLD implementation pulmonary rehabilitation (PR).METHODS: A panel global experts in field TB care PR was identified; 62 participated a Delphi process. 5-point Likert scale used score initial ideas for after several rounds revision document approved (with 100% agreement).RESULTS: Five were...
TB affects around 10.6 million people each year and there are now 155 survivors. its treatments can lead to permanently impaired health wellbeing. In 2019, representatives of affected communities attending the '1st International Post-Tuberculosis Symposium´ called for development clinical guidance on these issues. This statement post-TB wellbeing responds this call builds work symposium, which brought together survivors, healthcare professionals researchers. Our document offers expert...
Abstract This study investigates the humoral and cellular immune responses health-related quality of life measures in individuals with mild to moderate long COVID (LC) compared age gender matched recovered COVID-19 controls (MC) over 24 months. LC participants show elevated nucleocapsid IgG levels at 3 months, higher neutralizing capacity up 8 months post-infection. Increased spike-specific nucleocapsid-specific CD4 + T cells, PD-1, TIM-3 expression on CD8 cells were observed but these...
Non-communicable diseases (NCDs) cause a large burden of disease globally. Some infectious an increased risk developing specific NCDs. Although the NCD from some causes has been quantified, in this study, we aimed to more comprehensively quantify global NCDs causes.In modelling identified with established factors and long-term non-communicable sequelae, did narrative reviews between April 11, 2018, June 10, 2020, obtain relative risks (RRs) or population attributable fractions (PAFs) studies...
To determine the prevalence and natural history of post-acute COVID-19 objective cognitive impairment function, their relationship to demographic, clinical factors, sequelae (PASC), biomarkers.A total 128 patients (age = 46 ± 15; 42% women, acute disease severity: not hospitalized: 38.6% mild: 0-1 symptoms, 52% 2+ symptoms; 9.4% hospitalized) completed standard cognition, olfaction, mental health examinations 2-, 4-, 12-month post diagnosis. Over same time frame, WHO-defined PASC was...
In 2020, it was estimated that there were 155 million survivors of TB alive, all at risk possible post disability. The 2 nd International Post-Tuberculosis Symposium (Stellenbosch, South Africa) held to increase global awareness and empower TB-affected communities play an active role in driving the agenda. We aimed update knowledge on post-TB life illness, identify research priorities, build collaborations highlight need embed lung health outcomes clinical trials programmatic care services....
There is an increased risk of patients with obstructive sleep apnea syndrome (OSAS) to have stroke or cardiac infarcts. Besides hypertension, epinephrine-induced platelet activation could be a further reason for the cardiovascular morbidity and mortality in OSAS.During 4-month period (August 1994 December 1994) we recruited prospectively 76 referred polysomnograms because suspected disorder such as OSAS.Fifty had no respiratory events during (non-OSAS), 19 more than five but less 50 apneas...
Objective To investigate the association between blood–brain barrier permeability, brain metabolites, microstructural integrity of white matter, and cognitive impairment (CI) in post-acute sequelae SARS-COV-2 infection (PASC). Methods In this multimodal longitudinal MRI study 14 PASC participants with CI 10 healthy controls were enrolled. All completed investigations at 3 months following acute (3 ± 2 weeks SD), 12 2.22 SD weeks. The assessments included a standard neurological assessment,...
Abstract Cognitive impairment and function post-acute mild to moderate COVID-19 are poorly understood. We report findings of 128 prospectively studied SARS-CoV-2 positive patients. Cognition olfaction were assessed at 2-, 4- 12-months post-diagnosis. Lung function, physical mental health 2-month post diagnosis. Blood cytokines, neuro-biomarkers, kynurenine pathway (KP) metabolites measured 4-, 8- 12- months. Mild cognitive (demographically corrected) was present in 16%, 23%, 26%, diagnosis,...
Background Same-day HIV testing and antiretroviral therapy (ART) initiation is being widely implemented. However, the optimal timing of ART among patients with tuberculosis (TB) symptoms unknown. We hypothesized that same-day treatment (TB for those diagnosed TB; not TB) would be superior to standard care in this population. Methods findings conducted an open-label trial adults TB at initial diagnosis GHESKIO Haiti; participants were recruited randomized on same day. Participants a 1:1 ratio...
Background Accurately identifying COVID-19 episodes was crucial during the early pandemic for evaluating interventions. Results from diagnostic tools like PCR, rapid antigen test (RAT), and serology are affected by factors such as timing of tests vaccination status. The BRACE trial, which investigated impact BCG on prevalence among healthcare workers, developed a comprehensive algorithm integrating these illness episode classification. Methods In 3988 participants reported 5512...
Cross-sectional studies reveal an association between tuberculosis (TB) and chronic airflow obstruction, but cannot adequately address confounding. We hypothesised that treated pulmonary TB is independent risk factor for obstruction. The Pulmones Post cohort study enrolled participants from Lima, Peru, aged 10–70 years with a history of drug-susceptible (DS)- or multidrug-resistant (MDR)-TB who had completed treatment were clinically cured. Unexposed without randomly selected the same...
<b>In a longitudinal cohort, significant proportion of patients had persistent symptoms 8 months after initial #COVID19 infection. There was no improvement in or health-related quality life between 4- and 8-month assessments.</b>https://bit.ly/2Wtb7IX