A5101801831- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- interferon and immune responses
- NF-κB Signaling Pathways
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Spinal Fractures and Fixation Techniques
- Macrophage Migration Inhibitory Factor
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Folate and B Vitamins Research
- Cervical and Thoracic Myelopathy
- Kruppel-like factors research
- Osteoarthritis Treatment and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Electrolyte and hormonal disorders
- Healthcare and Venom Research
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- Inflammatory Biomarkers in Disease Prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- High-Velocity Impact and Material Behavior
- Apelin-related biomedical research
Guangzhou Medical University
2013-2024
Second Affiliated Hospital of Guangzhou Medical University
2013-2024
State Key Laboratory of Respiratory Disease
2024
The First Hospital of Changsha
2018-2024
Central South University
2024
Nanjing University of Aeronautics and Astronautics
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Zhengzhou City Hospital
2020-2022
Background: Sepsis is a deadly disease worldwide. Effective treatment strategy of sepsis remains limited. There still was controversial about association between preadmission metformin use and mortality in patients with diabetes. We aimed to assess sepsis-related type 2 diabetes (T2DM) who were non-metformin users. Methods: The T2DM included from Medical Information Mart for Intensive Care -III database. Outcome 30-day mortality. used multivariable Cox regression analyses calculate adjusted...
miRNAs have recently been shown to play a significant role in human aging. However, data demonstrating the effects of aging-related mesenchymal stem cells (hMSCs) are limited. We observed that hMSC differentiation decreased with also identified miR-10a expression was significantly age by comparing miRNA hMSCs derived from young and aged individuals. Therefore, we hypothesized downregulation may be associated capability Lentiviral constructs were used up- or downregulate old hMSCs....
Aging is one of the key factors that regulate function human bone marrow mesenchymal stem cells (hBM-MSCs) and related changes in microRNA (miRNA) expression. However, data reported on aging-related miRNA hBM-MSCs are limited. We demonstrated previously miR-10a significantly decreased aged restoration level attenuated cell senescence increased differentiation capacity by repressing Krüpple-like factor 4 (KLF4). In present study, was overexpressed or KLF4 downregulated old lentiviral...
Introduction: Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D). Magnesium has also reported to be lower T2D risk. Besides, magnesium is an essential cofactor for activation. However, effect dietary intake on association between and not studied comprehensively. Therefore, we designed this cross-sectional study assess modification T2D. Research Design Methods: The present analyzed data from National Health Nutrition Examination Survey (NHANES)...
The non-detection of periodicity related to rotation challenges the magnetar model for fast radio bursts (FRBs). Moreover, a bimodal distribution burst waiting times is widely observed in hyper-active FRBs, significant deviation from exponential expected stationary Poisson processes. By combining epidemic-type aftershock sequence (ETAS) earthquake and rotating vector (RVM) involving orientations spin magnetic axes, we find that starquake events modulated by FRB-emitting can explain FRB...
Hemodynamic management is of paramount importance in patients with acute kidney injury (AKI). Central venous pressure (CVP) has been used to assess volume status. We intended identify the optimal time window which obtain CVP avoid incidence adverse outcomes AKI.The study was based on Medical Information Mart for Intensive Care (MIMIC) IV database. The primary outcome in-hospital mortality. Secondary included number ICU-free days and norepinephrine-free at 28 after ICU admission, total fluid...
Acute kidney injury (AKI) is one of the most common organ dysfunction in sepsis, and increases risk unfavourable outcomes. Renal replacement therapy (RRT) predominant treatment for sepsis-associated AKI (SAKI). However, to date, no prospective randomised study has adequately addressed whether initiating RRT earlier will attenuate renal improve outcome sepsis. The objective trial compare early strategy with delayed on outcomes patients SAKI intensive care unit (ICU).This a large-scale,...
Inflammation is a common pathophysiological process as well clinical threat that occurs in various diseases worldwide. It well-documented nuclear factor-κB (NF-κB) and mitogen-activated protein kinase pathways are involved inflammatory reactions to microbial infections lipopolysaccharide (LPS)-activated macrophages. The deubiquitinase ubiquitin carboxyl-terminal hydrolase-L1 (UCHL1) has been reported an oncoprotein promote the growth progression of cancer cells. However, regulatory mechanism...
Objective This study aimed to assess whether β-blockers are associated with mortality in patients sepsis. Method We conducted a retrospective cohort of sepsis using the Medical Information Market for Intensive Care (MIMIC)-IV and emergency intensive care unit (eICU) databases. The primary outcome was in-hospital rate. propensity score matching (PSM) method adopted reduce confounder bias. Subgroup sensitivity analyses were performed test stability conclusions. Results included total 61,751...
Abstract Hypoxia is important in ischemic heart disease. Excessive Insulin-like growth factor binding protein-1 (IGFBP-1) amounts are considered to harm cardiomyocytes acute myocardial infarction. However, the mechanisms by which IGFBP-1 affects remain undefined. The present study demonstrated that hypoxia up-regulates and HIF-1α protein expression cardiomyocytes. Subsequent assays showed suppression decreased inhibited hypoxia-induced apoptosis cardiomyocytes, was reversed overexpression,...
b-AP15 is a deubiquitinase (DUB) inhibitor of 19S proteasomes, which in turn targets ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14). Nuclear factor kappa B (NF-κB) closely linked to cellular response macrophages when the organism state microbial infection, it acts as vital part mechanism inflammatory reaction. However, molecular by DUB inhibitors, especially b-AP15, regulates inflammation remains poorly understood. This study aimed investigate...
BackgroundThe Albumin-Bilirubin (ALBI) score, recommended for assessing the prognosis of hepatocellular carcinoma patients, has garnered attention. The efficacy ALBI score in forecasting risk death sepsis patients remains limited. We designed two cohort studies to assess association between and in-hospital mortality with sepsis.MethodsA retrospective analysis was conducted utilizing data from Second Affiliated Hospital Guangzhou Medical University Information Mart Intensive Care...
Abstract Background Micropapillary (MPP) adenocarcinoma is considered one of the most aggressive pathological types lung (LADC). This retrospective study aimed to evaluate prognostic significance and benefit postoperative adjuvant therapy (PAT) in stage IA LADC patients with different proportions MPP components. Materials methods We retrospectively examined clinical who underwent surgical resection between August 2012 December 2019. In terms proportion components (TPM), tumors were...
Study Design A retrospective review of clinical and radiological parameters. Objective To evaluate the therapeutic efficacy transpedicular impaction bone grafting (TIBG) with long segmental posterior instrumentation for treatment stage III Kümmell disease. Summary Background Data The optimal disease remains controversial unclear. Theoretically, can reconstruct anterior column support reduce failure internal fixation, which is an intuitive method However, use this technique has rarely been...
Abstract Background Septic patients with cardiac impairment are high mortality. Afterload-related performance (ACP), as a new tool for diagnosing septic cardiomyopathy (SCM), still needs to be evaluated its impact on the prognosis shock. Methods In this retrospective study, 100 shock undertaken PiCCO monitoring were included. The ability of ACP, index (CI), and power (CPI) discriminate between survivors non-survivors was tested by comparing area under receiver operating characteristic curve...
Recent studies have highlighted observations regarding re-tested positivity (RP) of SARS-CoV-2 RNA in discharged COVID-19 patients, however, the immune mechanisms underlying RP immunocompetent patients remain elusive. Herein, we describe case an patient with moderate symptoms who was twice as positive for RNA, and period between first third viral 95 days, longer than previously reported (18–25 days). The chest computed tomography findings, plasma anti-SARS-CoV-2 antibody, neutralizing...
Aims The mortality of critically ill patients undergoing mechanical ventilation (MV) is high and few strategies are available. We explored the relationship between ondansetron pre‐treatment, neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte (PLR), ventilated in intensive care unit. Methods developed a retrospective cohort study that involved MV Multiparameter Intelligent Monitoring Intensive Care IV (MIMIC‐IV) database. Causal mediation analysis was conducted to assess use explore...
Spinal cord injury is a common occurrence during spinal surgery. In this study, we proposed zoning laminectomy, which could reduce the incidence of nerve injury. We also discussed safety and clinical efficacy laminectomy for thoracic ossification ligamentum flavum (TOLF).Forty-five patients with TOLF who underwent from October 2016 to February 2020 were included in retrospective analysis. The Japan Orthopedic Association (JOA) score was used evaluate outcomes. Meanwhile, complications...
Background Soluble transferrin receptor (sTfR)/log ferritin index (sTfR Index) can be used to assess the entire spectrum of iron status, and is valuable in evaluating status population studies. There still a lack evidence on association between sTfR all-cause mortality. Object To explore mortality, as well mortality due cardiovascular disease (CVD) cancer. Method Data were from National Health Nutrition Examination Survey (NHANES) 2003 2020. Participants aged 16 years older who had complete...
In recent years, the use of shear-wave elastography (SWE) as a diagnostic tool for detecting malignant breast lesions has shown promising results. This study aims to determine clinical value SWE in nipple retraction.
Background There is accumulating evidence regarding the benefits of 5-HT 3 receptor antagonist ondansetron for treatment critical illness due to its potential anti-inflammatory effect. This study attempted determine targets and molecular mechanisms ondansetron’s action against illnesses. Methods A bioinformatics analysis network pharmacology was conducted demonstrate screening signaling pathways most common illnesses such as acute kidney injury (AKI), sepsis, respiratory distress syndrome...