A5061470186- Plant Virus Research Studies
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Resistance
- Plant Disease Resistance and Genetics
- Plant Reproductive Biology
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Plant Molecular Biology Research
- Potato Plant Research
- Plant Gene Expression Analysis
- Genomics and Phylogenetic Studies
- Plant Stress Responses and Tolerance
- Scientific Computing and Data Management
- Cocoa and Sweet Potato Agronomy
- Biomedical and Engineering Education
- Gene expression and cancer classification
- Research Data Management Practices
- COVID-19 Clinical Research Studies
- Sirtuins and Resveratrol in Medicine
- Computational Drug Discovery Methods
- Genetics, Bioinformatics, and Biomedical Research
- Plant responses to water stress
- Plant Parasitism and Resistance
- Wheat and Barley Genetics and Pathology
- Phytoplasmas and Hemiptera pathogens
National Institute of Biology
2016-2025
RWTH Aachen University
2013
Enabling data reuse and knowledge discovery is increasingly critical in modern science, requires an effort towards standardising publication practices. This particularly challenging the plant phenotyping domain, due to its complexity heterogeneity. We have produced MIAPPE 1.1 release, which enhances existing standard coverage, support perennial plants, structure, through explicit model, clarity, definitions examples. evaluated by using it express several heterogeneous experiments a range of...
Presently, pearl millet and wheat are belonging to highly important cereal crops. Pearl millet, however, is an under-utilized crop, despite its superior resilience drought heat stress in contrast wheat. To investigate this more detail, we performed comparative physiological screening large scale proteomics of responses drought-tolerant susceptible genotypes These chosen widely used breeding farming practices. The demonstrated differences the regulation root morphology photosynthetic...
PaintOmics is a web server for the integrative analysis and visualisation of multi-omics datasets using biological pathway maps. 4 has several notable updates that improve extend analyses. Three databases are now supported: KEGG, Reactome MapMan, providing more comprehensive knowledge animals plants. New metabolite methods fill gaps in traditional pathway-based enrichment methods. The hub selects compounds with high number significant genes their neighbouring network, suggesting regulation...
The stilbenoid pathway is responsible for the production of resveratrol in grapevine (Vitis vinifera L.). A few transcription factors (TFs) have been identified as regulators this but extent control has not deeply studied. Here we show how DNA affinity purification sequencing (DAP-Seq) allows genome-wide TF-binding site interrogation grape. We obtained 5190 and 4443 binding events assigned to 4041 3626 genes MYB14 MYB15, respectively (approximately 40% peaks located within −10 kb start...
ABSTRACT Abscission is a tightly regulated process in which plants shed unnecessary, infected, damaged, or aging organs, as well ripe fruits, through predetermined abscission zones response to developmental, hormonal, and environmental signals. Despite its importance, the underlying mechanisms remain incompletely understood. This study highlights deleterious effects of on chloroplast ultrastructure cells tomato flower pedicel zone, revealing spatiotemporal differential gene expression key...
GoMapMan (http://www.gomapman.org) is an open web-accessible resource for gene functional annotations in the plant sciences. It was developed to facilitate improvement, consolidation and visualization of across several species. based on MapMan ontology, organized form a hierarchical tree biological concepts, which describe functions. Currently, genes model species Arabidopsis three crop (potato, tomato rice) are included. The main features (i) dynamic interactive product annotation through...
Theobroma cacao and its popular product, chocolate, are attracting attention due to potential health benefits including antioxidative effects by polyphenols, anti-depressant high serotonin levels, inhibition of platelet aggregation prevention obesity-dependent insulin resistance. The development seeds during fruit ripening is the most crucial process for accumulation these compounds. In this study, we analyzed primary secondary metabolome as well proteome cv. Forastero seed applying an...
Stress Knowledge Map (SKM; https://skm.nib.si) is a publicly available resource containing two complementary knowledge graphs that describe the current of biochemical, signaling, and regulatory molecular interactions in plants: highly curated model plant stress signaling (PSS; 543 reactions) large comprehensive network (488 390 interactions). Both were constructed by domain experts through systematic curation diverse literature database resources. SKM provides single entry point for...
Glioblastoma multiforme is the most lethal of brain cancer, and it comprises a heterogeneous mixture functionally distinct cancer cells that affect tumor progression. We examined U87, U251, U373 malignant cell lines as in vitro models to determine impact cellular cross-talk on their phenotypic alterations co-cultures. These were also studied at transcriptome level, define mechanisms observed mutually affected genomic stability, proliferation, invasion resistance temozolomide. This first...
Potato virus Y (PVY) is a major pathogen that causes substantial economic losses in worldwide potato production. Different cultivars differ resistance to PVY, from severe susceptibility, through tolerance, complete resistance. The aim of this study was better define the mechanisms underlying tolerant responses infection by particularly aggressive PVYNTN strain. We focused on dynamics primary metabolism-related processes during infection. A comprehensive analysis dynamic changes metabolism...
Summary The nutritional value of wheat grains, particularly their protein and metabolite composition, is a result the grain‐filling process, especially in endosperm. Here, we employ laser microdissection (LMD) combined with shotgun proteomics metabolomics to generate cell type‐specific proteome metabolome inventory developing endosperm at early (15 DAA) late (26 stages. We identified 1803 proteins 41 metabolites from four different types (aleurone (AL), sub‐aleurone (SA), starchy (SE)...
Potato virus Y is the most economically important potato viral pathogen. We aimed at unraveling roles of small RNAs (sRNAs) in complex immune signaling network controlling establishment tolerant response cv. Désirée to virus. constructed a sRNA regulatory connecting sRNAs and their targets link level responses physiological processes. discovered an interesting novel sRNAs-gibberellin circuit being activated as early 3 days post inoculation before multiplication can be detected. Two...
To develop novel crop breeding strategies, it is crucial to understand the mechanisms underlying interaction between plants and their pathogens. Network modeling represents a powerful tool that can unravel properties of complex biological systems. In this study, we aimed use network better immune signaling in potato (Solanum tuberosum). For this, first built on reliable Arabidopsis (Arabidopsis thaliana) model, extending with information from diverse publicly available resources. Next,...
Although the reference genome of Solanum tuberosum Group Phureja double-monoploid (DM) clone is available, knowledge on genetic diversity highly heterozygous tetraploid Tuberosum, representing most cultivated varieties, remains largely unexplored. This lack hinders further progress in potato research. In conducted investigation, we first merged and manually curated two existing partially-overlapping DM genome-based gene models, creating a union genes scaffold. Next, compiled available newly...
Abstract Arbuscular mycorrhizal (AM) symbiosis can prime plant defenses, leading to mycorrhiza-induced resistance (MIR) against different attackers, including insect herbivores. Still, our knowledge of the complex molecular regulation MIR is very limited. Here, we show that AM fungus Funneliformis mosseae protects tomato plants two chewing herbivores, Spodoptera exigua and Manduca sexta. We explore underlying mechanism through genome-wide transcriptional profiling, bioinformatics network...
Potato virus Y (PVY) is the most economically important viral pathogen of potato worldwide. Different cultivars react to differently, resulting in resistant, tolerant or disease outcome interaction. Here we focus on interaction between cv. Désirée and PVYNTN. To capture response its full complexity, analyzed dynamic changes multiple molecular levels, including transcriptomics, sRNAomics, degradomics, proteomics hormonomics. The analysis was complemented by measurements accumulation,...
Abstract Background Rosaceae species are economically highly relevant crops. Their cultivation systems constrained by phytopathogens causing severe losses. Plants respond to invading pathogens through signaling mechanisms, a component of which them being plant elicitor peptides (Peps). Exogenous application Peps activates defense mechanisms and reduces the symptoms pathogen infection in various pathosystems. We have previously identified showed, an ex vivo system, that their topical...
Abstract Background Hyperimmune convalescent COVID-19 plasma (CCP) containing anti-SARS-CoV-2 neutralizing antibodies (NAbs) was proposed as a therapeutic option for patients early in the new coronavirus disease pandemic. The efficacy of this therapy depends on quantity CCP units, with titers ≥ 1:160 being recommended. standard tests (NTs) used determining appropriate donors are technically demanding and expensive take several days. We explored whether they could be replaced by...
Bois noir is the most widespread phytoplasma grapevine disease in Europe. It associated with ‘Candidatus Phytoplasma solani’, but molecular interactions between causal pathogen and its host plant are not well understood. In this work, we combined analysis of high-throughput RNA-Seq sRNA-Seq data interaction network for finding new cross-talks among pathways involved infection cv. Zweigelt ‘Ca. P. solani’ early late growing seasons. While season was very dynamic at transcriptional level...
Summary Root colonization by certain beneficial microbes can prime plant defenses aboveground, modifying responses to potential attackers. Arbuscular mycorrhizal (AM) fungi establish mutualistic symbiosis with most species, usually enhancing resistance biotic stresses, leading Mycorrhiza-Induced Resistance (MIR). Still, our knowledge of the complex molecular regulation MIR is very limited. Here we show that AM fungus Funneliformis mosseae protects tomato plants against two different chewing...
Biomine Explorer is a web application that enables interactive exploration of large heterogeneous biological networks constructed from selected publicly available knowledge sources. It built on top Biomine, system which integrates cross-references several databases into probabilistic network. offers user-friendly interfaces for search, visualization, and manipulation as well public private storage discovered subnetworks with permanent links suitable inclusion scientific publications. A...
Plant biofactories are a promising platform for sustainable production of high-value compounds, among which insect sex pheromones, green alternative to conventional insecticides in agriculture. Recently, we have constructed transgenic Nicotiana benthamiana plants (“Sexy Plants”, SxP) that successfully produce blend moth (Lepidoptera) pheromone compounds ( Z )-11-hexadecen-1-ol and )-11-hexadecenyl acetate. However, efficient biosynthesis pheromones resulted growth developmental penalty,...