A5100345590- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Insect Utilization and Effects
- interferon and immune responses
- Insect symbiosis and bacterial influences
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Insect Resistance and Genetics
- Immune cells in cancer
- Immune Cell Function and Interaction
- Silk-based biomaterials and applications
- Inflammasome and immune disorders
- Histone Deacetylase Inhibitors Research
- Poxvirus research and outbreaks
- Parasitic Infections and Diagnostics
- Venomous Animal Envenomation and Studies
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Silkworms and Sericulture Research
- Rabies epidemiology and control
- Protein Degradation and Inhibitors
- Lipid metabolism and disorders
- Skin Protection and Aging
- Adolescent Sexual and Reproductive Health
- Luminescence Properties of Advanced Materials
Southwest Medical University
2022-2025
Affiliated Hospital of Southwest Medical University
2025
First Affiliated Hospital of Sichuan Medical University
2023-2024
Southwest University
2013-2023
Shantou University Medical College
2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2023
Shanghai University of Traditional Chinese Medicine
2023
Shantou University
2023
Huazhong University of Science and Technology
2022
Tongji Hospital
2022
Microsporidia have attracted much attention because they infect a variety of species ranging from protists to mammals, including immunocompromised patients with AIDS or cancer. Aside the study on Nosema ceranae, few works focused elucidating mechanism in host response microsporidia infection. bombycis is pathogen silkworm pébrine that causes great economic losses industry. Detailed understanding (Bombyx mori) infection by N. helpful for prevention this disease. A genome-wide survey gene...
ABSTRACT Our previous studies have identified mitsugumin 53 (MG53) as a novel regulator for angiogenesis by directly entering endothelial cells and modulating focal adhesion kinase (FAK) activation, but little is known about how rhMG53 taken up mediates cell movement. In the present study, we demonstrated that knockdown of caveolin‐1 clathrin inhibitor, pitstop‐2, both significantly reduced entry into cells, indicating caveolae‐dependent clathrin‐dependent endocytosis during this process....
Hemolymph melanization is a conserved immune response in insects and other arthropods. However, the physiological process of hemolymph system hardly studied. Here, alterations hemocytes were observed by Escherichia coli infection Bombyx mori. Results first showed that there cells aggregating into clusters. it vanished, only part clustered melanized during period intense immunity. The hemocyte numbers immediately decreased following an challenge, slowly increased to peak, then reduced finally...
Abstract Background Mesenchymal stem cells (MSCs) therapies are emerging as a promising approach to therapeutic regeneration. Therapeutic persistence and reduced functional following cell delivery remain critical hurdles for clinical investigation due the senescence of freshly isolated extensive in-vitro passage. Methods Cultured adipose-derived (ASCs) were derived from subcutaneous white adipose tissue mice fed normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal)...
The impairment of the angiopoietin-1 (Ang-1)/Tie-2 signaling pathway has been thought to play a critical role in diabetic complications. However, underlying mechanisms remain unclear. present study aims investigate effects Tie-2 glycation on Ang-1 activation and Ang-1-induced angiogenesis. We identified that was modified by advanced end products (AGEs) aortae derived from high fat diet (HFD)-fed mice methylglyoxal (MGO)-treated human umbilical vein endothelial cells (HUVECs). MGO-induced...
The gene-encoding farnesyl diphosphate O-methyltransferase 6 (FAMeT 6) is a member of the family. Our previous studies have demonstrated its influence on juvenile hormone levels in third instar silkworm larvae.
Influenza A viruses (IAV), significant respiratory pathogenic agents, cause seasonal epidemics and global pandemics in intra- interannual cycles. Despite effective therapies targeting viral proteins, the continuous generation of drug-resistant IAV strains is challenging. Therefore, exploring novel host-specific antiviral treatment strategies urgently needed. Here, we found that lidocaine, widely used for local anesthesia sedation, significantly inhibited H1N1(PR8) replication macrophages....
Insect immune-associated phospholipase A2 (PLA2 ) is an important target of pathogen invasion. Melanization, effective defense response, has significant correlations with other immune responses to coordinate attack against invaders. However, the effect PLA2 on melanization not yet been reported in insects or arthropods. In this work, we cloned a gene (BmsPLA2 ), and its protein had characteristic features secreted (sPLA2 ). After injection bacteria, BmsPLA2 expression sPLA2 activity...
Dopamine is widely distributed in metazoans and implicated many physiological functions. Dopaminergic signaling mediated through two classes of dopamine receptors, D1-like D2-like. Phylogeny analysis reveals that, the receptors probably appeared ahead cnidarian divergence, distinct likely formed prior to separation deuterostomes protostomes, INDRs split from its ancestor before emergence nematodes. Two D2-like genes are closely linked on same scaffold, chromosome region around gene loci show...
The pathogenic hyper-inflammatory response has been regarded as the major cause of severity and death related to acute lung injury (ALI). Hua-ban decoction (HBD) is a classical prescription in traditional Chinese medicine (TCM). It extensively used treat inflammatory diseases; however, its bioactive components therapeutic mechanisms remain unclear. Here, we established lipopolysaccharide (LPS)-induced ALI model that presents hyperinflammatory process explore pharmaco-dynamic effect...
Juvenile hormone (JH) plays a vital role in the growth, development, and reproduction of insects other arthropods. Previous experiments have suggested that BmFAMeT6 could affect duration silk moth’s larval stage. In this study, we established overexpression strain knockout using GAL4/UAS binary hybrid system CRISPR/Cas 9 system, respectively, found stage was shorter, while longer. Our results exhibited both JH titers BmKr-h1 levels larvae third instar were reduced significantly by...