A5047827292- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Infections and bacterial resistance
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Urinary Tract Infections Management
- Actinomycetales infections and treatment
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- Long-Term Effects of COVID-19
- Enterobacteriaceae and Cronobacter Research
- Thyroid Disorders and Treatments
- Infectious Diseases and Mycology
- Orthopedic Infections and Treatments
- Drug Transport and Resistance Mechanisms
- COVID-19 and healthcare impacts
- Healthcare Systems and Reforms
- Fungal Infections and Studies
Kartal Koşuyolu High Specialization Training and Research Hospital
2017-2025
Sağlık Bilimleri Üniversitesi
2017-2024
University of Health Science
2022-2024
Recep Tayyip Erdoğan University
2018
Turkish Society of Hematology
2017
We describe the molecular characteristics of colistin resistance and its impact on patient mortality. A prospective cohort study was performed in seven different Turkish hospitals. The genotype each isolate determined by MLST repetitive extragenic palindromic PCR (rep-PCR). Alterations mgrB were detected sequencing. Upregulation pmrCAB, phoQ pmrK quantified RT–PCR. mcr-1 genes encoding OXA-48, NDM-1 KPC amplified PCR. total 115 patients diagnosed with colistin-resistant K. pneumoniae...
Whether an anticoagulation strategy combining bivalirudin and aspirin during extracorporeal membrane oxygenation (ECMO) would prolong oxygenator use is unknown. No clear data exist on life span prolonged ECMO use. We evaluated 70 adult patients who received due to coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome for at least 7 days required no or one replacement ECMO-circuit thrombosis. Anticoagulation parameters mainly included activated partial...
Objectives: We aimed to describe the mechanisms of colistin resistance in Acinetobacter baumannii. Materials and Methods: Twenty-nine patients diagnosed with colistin-resistant A. baumannii infection were included study. The mutations pmrCAB, lpxA, lpxC, lpxD genes, expression carbapenemases, mcr-1 positivity studied. Results: Twenty-seven (93%) received IV therapy during their stay, case fatality rate was 45%. All pmrC pmrB found be accompanied a mutation lpxD. most common I42V L150F (65%),...
Here, we presented 11 cases with colistin-resistant Pseudomonas aeruginosa infection and co-existence of OXA-48 NDM-1 in the ST235 high-risk clone. The molecular analyses were performed by Sanger sequencing RT–PCR. eight patients (72.7%) had an invasive three (27.3%) colonization. 30-day mortality rate was 87.5% (7/8). Three (37.5%, 3/8) received colistin therapy before isolation P. aeruginosa. In Multilocus sequence typing (MLST) analysis isolates, isolates belonged to All positive, nine...
<h2>Abstract</h2><h3>Background</h3> The aim of this study was to determine the effect colistin resistance and other predictors on fatality among patients with <i>Klebsiella pneumoniae</i> bloodstream infections (Kp-BSI) describe amikacin tigecycline outcome in an OXA-48 dominant country. <h3>Method</h3> This a retrospective performed >16 years age tertiary hospital 465 beds. All cases had ≥1 positive blood culture for <i>K. 48 h after admission. <h3>Results</h3> Among 210 Kp-BSI, 30-day...
Background Cefiderocol is generally active against carbapenem-resistant Klebsiella spp. (CRK) with higher MICs metallo-beta-lactamase producers. There a variation in cefiderocol interpretive criteria determined by EUCAST and CLSI. Our objective was to test CRK isolates compare susceptibilities using CLSI criteria.Methods A unique collection (n = 254) of mainly OXA-48-like- or NDM-producing bloodstream were tested disc diffusion (Mast Diagnostics, UK). Beta-lactam resistance genes multilocus...
Background: In this study, we present our experience in treating patients receiving extracorporeal membrane oxygenation for novel coronavirus disease-2019 (COVID-19)-associated acute respiratory distress syndrome using a combined anticoagulant and antiaggregant treatment with intravenous infusion of bivalirudin aspirin. Methods: Between April 1 st , 2020 January 31 2022, total 52 adult (32 males, 20 females; mean age: 44.5±11.5 years; range, 21 to 71 years) who received due...
Ralstonia pickettii infections are rare and may be mistaken for other bacteria. This study aims to report a hospital outbreak of R. at tertiary hospital, which was initially misidentified as insidiosa, along with its clinical consequences.A bacteraemia occurred between August 14 October 4, 2019, infecting 22 patients admitted diverse intensive care units. All isolates were identified the use automated VITEK 2 Compact system then subjected microbial identification system, matrix-assisted...
Infective endocarditis (IE) is rare, but associated with significant morbidity and mortality rates. Estimates of the incidence IE in Turkey are compromised by absence population-based prospective studies. Due to frequent presence predisposing cardiac conditions higher rates nosocomial bacteremia highrisk groups, expected be Turkey. Additionally, while generally affects older people developed countries, it still young In order reduce morbidity, critical diagnose determine causative agent...
Introduction: We sought to evaluate secondary infections (SIs) in patients admitted the intensive care unit (ICU) for COVID-19 with respect incidence, causative pathogens, and clinical outcomes.
 Methodology: In this two-centre retrospective study, we analysed 146 (96 males, 50 females; median age, 64 years) ICU between March 26 December 31, 2020. Inclusion criteria were an admission at least 48 hours age beyond 18 years. Patients without SIs compared impacts of carbapenem resistance on...
Aim: The aim of this study is to evaluate the attitudes healthcare workers against seasonal influenza vaccine and reasons for avoidance. Materials Methods: This national survey was conducted from April 1st June 30th in 2017. carried out among health care working primary, secondary tertiary settings. A total 12 questions were sent 5046 professionals 55 different cities who agreed participate survey.Results: 7% participants stated that they get vaccinated regularly every year. 65.8% don’t at...
Colistin resistance in Acinetobacter baumannii is an emerging problem that limits antimicrobial therapy options.
is a gram-negative bacterium that rarely leads to infective endocarditis. We presented an interesting case of late dehiscence aortic valve conduit, eight years after the Benthall-DeBono procedure, because anastomotic leakage from distal end conduit and resultant large pseudoaneurysm severe paravalvular insufficiency in setting endocarditis caused by
Data in the literature on use of ceftazidime-avibactam (CAZ-AVI) carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially OXA-48 (Oxacillinase-48) predominant regions. Our study aimed to evaluate effect CAZ-AVI outcomes CRKP-BSIs Turkey, where is endemic. A multicenter retrospective observational was conducted between January 2017 and September 2021. The effects clinical treatment characteristics 30-day mortality relapse were analyzed. Predictors...
Ministry of Health (TMOH) requires two patients per nurse in level 3 ICUs, three 2 ICUs and five 1 ICUs.There is no standardization for the number AHCW ICUs.Finally, one ICP 150 hospital beds required by TMOH.Results: The total ICU ICPs were 214, 2377 111, respectively he 41 participated centers.The was adequate only 12 hospitals.The percentage nurses whose working experience <1 year, was; 19% 25% 24% ICUs.The mostly <5 whereas generally >2.The other HCW minimum 3.75 maximum 4.89 on weekdays...