A5024612683- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive natural compounds
- Chromatography in Natural Products
- Innovation and Knowledge Management
- Immune Response and Inflammation
- Endodontics and Root Canal Treatments
- Pneumonia and Respiratory Infections
- S100 Proteins and Annexins
- COVID-19 Clinical Research Studies
- Corporate Finance and Governance
- Antibiotic Use and Resistance
- Family Business Performance and Succession
- Hepatitis Viruses Studies and Epidemiology
- Immune cells in cancer
- Phytochemistry and Bioactivity Studies
- Synthesis of Indole Derivatives
- Radiopharmaceutical Chemistry and Applications
- Cleft Lip and Palate Research
- Single-cell and spatial transcriptomics
- Hepatitis C virus research
- Ethnobotanical and Medicinal Plants Studies
- Phytochemistry Medicinal Plant Applications
- Dental Anxiety and Anesthesia Techniques
Vokkaligara Sangha Dental College & Hospital
2024
Oxford Dental College and Hospital
2024
Jazan University
2024
Government Dental College and Hospital
2024
King Khalid University
2024
Sriram Chandra Bhanja Medical College Hospital
2024
University of Massachusetts Amherst
2019-2023
Klinikum rechts der Isar
2018-2021
Technical University of Munich
2018-2021
All India Institute of Medical Sciences Bhopal
2021
Alloantigen-specific human regulatory T cells may improve immunosuppressive therapy after transplantation.
Abstract Stable expression of Foxp3 in regulatory T cells (Tregs) depends on DNA demethylation at the Treg-specific demethylated region (TSDR), a conserved, CpG-rich within locus. The TSDR is selectively ex vivo Tregs purified from secondary lymphoid organs, but it unclear which stage Treg development takes place. In this study, we show that commitment to stable lineage occurred during early stages murine thymic by engraving lineage-specific epigenetic marks parallel with establishment gene...
Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared nondiseased, individuals. Treg dysfunction could be primary, causal event or may result perturbations the immune system during disease development. Polymorphisms genes associated function, such as IL2RA, confer higher risk disease....
Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish transcriptional signature of central nervous system (CNS) that accumulate during experimental autoimmune encephalitis (EAE) identify pathway maintains function severe inflammation. This is dependent on the regulator Blimp1, which prevents downregulation Foxp3 expression "toxic" gain-of-function CNS....
Background: The disease severity, ranging from being asymptomatic to having acute illness, and associated inflammatory responses has suggested that alterations in the gut microbiota may play a crucial role development of chronic disorders due COVID-19 infection. This study describes dysbiosis patients its implications relating disease. Design: A cross sectional prospective was performed on thirty RT-PCR-confirmed admitted All India Institute Medical Sciences, Bhopal, India, between September...
The prevalence of antimicrobial resistance in India is among the highest world. Antimicrobial use inpatient settings an important driver resistance, but poorly characterized, particularly hospitalized children. In this study, conducted as part Global Resistance, Prescribing, and Efficacy Neonates Children (GARPEC) project, we examined indications use, well agents used children by conducting four point surveys six hospitals between February 2016 2017. A total 681 were across all survey days,...
This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used prophylaxis among pediatric patients hospitalized 41 countries worldwide.Using standardized Antibiotic Resistance and Prescribing European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey at 226 hospitals from October 1 November 30, 2012.Overall, 17693 were surveyed 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242...
Mugwort has many traditional uses around the world. The Chumash Indians of California use it to treat imbalances that women may suffer such as premenstrual syndrome, dysmenorrhea and menopausal symptoms. plant contains a sesquiterpene appears work through serotonergic mechanism be beneficial for women. therapy is safer than hormone replacement therapy. Children affected by attention deficit hyperactivity disorder benefit from mugwort There no doubt these children methylphenidate or amphetamine.
Background and aim: A sessile multicellular organism that is immersed in a self-produced matrix of extracellular polymeric substances has its cells firmly attached to surface referred as microbial biofilm. When it comes pulp periradicular pathosis, biofilms are crucial. To reduce the number microorganisms root canal assist treating periapical endodontic therapy must include decontamination system tooth canals through biomechanical preparation irrigation canal. This study compares sodium...
Background: Despite substantial breakthroughs in instrumentation systems and pharmaceutical interventions, pain following endodontic therapy remains a serious concern. The effect of the type system post-operative after has been matter debate. Aim: To evaluate different systems, namely Reciproc (GmbH, Munich), OneShape® (MicroMega, France), Protaper Gold (Dentsply Sirona, USA), Hyflex® EDM (Coltène/Whaledent Inc., USA) file regarding Methods materials: department treated healthy patients aged...
Regulatory T cells (Tregs) are potential immunotherapeutic candidates to induce transplantation tolerance. However, stability of Tregs still remains contentious and may potentially restrict their clinical use. Recent work suggested that epigenetic imprinting Foxp3 other Treg-specific signature genes is crucial for stabilization immunosuppressive properties Foxp3+ Tregs, these events initiated already during early stages thymic Treg development. the mechanisms governing this process remain...
Foxp3+ regulatory T cells are well-known immune suppressor in various settings. In this study, we provide evidence that knockout of the relB gene dendritic (DCs) C57BL/6 mice results a spontaneous and systemic accumulation (Tregs) partially at expense microbiota-reactive Tregs. Deletion nfkb2 does not fully recapitulate phenotype, indicating alternative NF-κB activation via RelB/p52 complex is solely responsible for Treg accumulation. RelB DCs further an impaired oral tolerance induction...
The aim of this study was to measure the level Oncostatin M (OSM) a gp130 cytokine in gingival crevicular fluid (GCF) and serum chronic periodontitis patients find any correlation between them before after periodontal therapy (scaling root planing, SRP). 60 subjects (age 25–50 years) were enrolled into three groups (n=20 per group), group I (healthy), II (gingivitis) III (chronic periodontitis). Group followed for 6–8 weeks initial (SRP) as IV (after therapy). Clinical parameters assessed...
Abstract Antibodies to antigens in the Kell blood group system are usually immunoglobulin G, and, notoriously, anti-K, anti-k, and anti-Kp a can cause severe hemolytic transfusion reactions, as well disease of fetus newborn (HDFN). It has been shown that titer anti-K does not correlate with severity HDFN because, addition immune destruction red cells (RBCs), causes suppression erythropoiesis fetus, which result anemia. We report case involving one twin was anemic other not. Standard...
Background and aimsCoronavirus disease (COVID-19) exhibits a range of clinical symptoms, including viral pneumonia, which can progress to acute respiratory distress syndrome, substantial alveolar destruction, even multi-organ failure in severe cases. Disease pathology is greatly influenced by the host immune response. Several studies reported perturbation T-cell responses COVID-19 patients. Activation differentiation CD4+ T cells into various subsets depend on expression lineage-specific...
Phytochemical examination of the benzene extract leaves Pongamia glabra resulted in isolation a new component 4'–methoxy furano (2",3": 7,8)/–flavone. It was identified by chemical and spectroscopic methods.