A5054811589- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Diabetes Management and Research
- Eosinophilic Disorders and Syndromes
- Cancer Immunotherapy and Biomarkers
- Chemical and Physical Studies
- Medical and Biological Sciences
- Acute Myeloid Leukemia Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Whipple's Disease and Interleukins
University of Turku
2018-2024
Åbo Akademi University
2018-2024
Turku Centre for Computer Science
2020-2024
Turku Centre for Biotechnology
2018
Estrogen receptor α promotes T cell activation and exacerbates autoimmune disease.
Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed identify transcriptional changes associated with progression in patients recent-onset type diabetes.Whole-blood samples were collected as part of INNODIA at baseline and 12 months after diagnosis diabetes. We used linear mixed-effects modelling on RNA-seq data genes age, sex, progression. Cell-type proportions estimated from using...
Abstract Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The aim the study was to assess early DNA methylation changes associated with type already before diagnosis or even appearance autoantibodies. Methods Reduced representation bisulphite sequencing (RRBS) applied in purified CD4 + T cell, CD8 cell and − fractions 226...
Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes children who develop islet-specific antibodies either insulin (IAA) or glutamic acid decarboxylase (GADA) as first autoantibodies. Here, we test hypothesis that later disease different early immune responses, depending on of autoantibody appear (GADA-first IAA-first). We use mass cytometry for deep profiling peripheral blood mononuclear cell samples longitudinally collected from progressed (IAA-first,...
The transcriptional network and protein regulators that govern T helper 17 (Th17) cell differentiation have been studied extensively using advanced genomic approaches. For a better understanding of these biological processes, we moved step forward, from gene- to protein-level characterization Th17 cells. Mass spectrometry-based label-free quantitative (LFQ) proteomics analysis were made in vitro differentiated murine induced regulatory (iTreg) More than 4,000 proteins, covering almost all...
Abstract Clonal hematopoiesis (CH) becomes more prevalent with age and may impact the pathophysiology of inflammatory diseases by altering immune cell function. While clonal indeterminate potential (CHIP) can promote inflammation in non-malignant conditions, relationship rheumatoid arthritis (RA) has not been systematically investigated. We tested whether CHIP mutations are common RA using two population-level cohorts newly diagnosed patients. was associated FINRISK study 10 089 participants...
Women are more frequently affected by autoimmune disorders than men. A role for estrogen was suggested the observation that development of inflammatory bowel disease associated with oral contraceptive use. also respond to infection and vaccination higher antibody production a T helper 2 (TH2) cell–dominant immune responses, whereas men usually show TH1 cell–biased responses.