A5004350949- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Obesity, Physical Activity, Diet
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Cystic Fibrosis Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Erythrocyte Function and Pathophysiology
- Advanced Glycation End Products research
- Hedgehog Signaling Pathway Studies
- Dietary Effects on Health
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
Bambino Gesù Children's Hospital
2006-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1997-2024
Helsinki University Hospital
2022
University of Helsinki
2022
Boston Children's Hospital
2002-2011
University of Rome Tor Vergata
2010
Diabetes Australia
2008
Endocrinology Research Center
2006
Weatherford College
2000
Sapienza University of Rome
1999
Nonalcoholic fatty liver disease (NAFLD), a common cause of chronic in adults, is incompletely characterized children. We conducted prospective study to better characterize the clinical presentation NAFLD children and determine effect lifestyle advice management pediatric NAFLD. From June 2001 April 2003, 84 (age 3-18.8 yr) who had elevated aminotransferases diagnosis confirmed via biopsy underwent 2-hour oral glucose tolerance test 12-month program consisting diet physical exercise....
Few data are available on the effect of antioxidants in paediatric non-alcoholic fatty liver disease (NAFLD).To compare a nutritional programme alone or combined with alpha-tocopherol and ascorbic acid alanine aminotransferase (ALT) levels, insulin resistance (IR) biopsy-proven NAFLD children.IN 12-month double-blind placebo study, 90 patients were prescribed balanced calorie diet (25-30 cal/kg/d), physical exercise, (group A) 600 IU/day plus 500 mg/day B). IR was estimated by homeostasis...
Waist circumference is widely accepted as a risk factor for cardiovascular disease and metabolic syndrome. Non-alcoholic fatty liver (NAFLD) feature of the A contribution syndrome, especially waist circumference, to fibrosis in children with NAFLD strongly suspected.Cross-sectional study.Department Hepatogastroenterology Nutrition, Paediatric Hospital "Bambino Gesù", Rome, Italy.197 consecutive Caucasian (136 males 61 females) aged 3-19 years.Multivariable logistic regression models were...
Abstract Introduction Early and tight glycaemic control is crucial to prevent long‐term complications of Type 1 Diabetes (T1D). The aim our study was compare glucose metrics, including Time In Tight Range (TITR), in a real‐world setting. Methods We performed single‐centre cross‐sectional 534 children adolescents with T1D. Participants were divided into four groups (multiple daily injections + real‐time Continuous monitoring (CGM), multiple intermittently scanned CGM, sensor augmented pump...
Prevalence of non-alcoholic fatty liver disease (NAFLD) among children is increasing dramatically. It unclear why some patients develop steatohepatitis (NASH), fibrosis and cirrhosis from steatosis, others do not. A role for leptin has been claimed. This study aims to evaluate the relationship between leptin, insulin resistance (IR) NAFLD in children.In 72 biopsy-proven (aged 9-18 years; 51M/21F), fasting its soluble receptor (sOB-R) were measured; free index (FLI) was calculated as...
Abstract Background The INNODIA consortium has established a pan-European infrastructure using validated centres to prospectively evaluate clinical data from individuals with newly diagnosed type 1 diabetes combined centralised collection of samples determine rates decline in beta-cell function and identify novel biomarkers, which could be used for future stratification phase 2 trials. Methods In this context, we have developed Master Protocol, based on the “backbone” natural history study,...
Childhood obesity is epidemic in developed countries and accompanied by an increase the prevalence of type 2 diabetes (T2DM).Establish glucose metabolism alterations a large sample overweight/obese children adolescents from Central Italy.The study group included 510 subjects (3-18 yr). Oral tolerance test (OGTT) was performed with insulin determination. Homeostatic model assessment resistance (HOMA-IR) sensitivity index (ISI) were derived fasting OGTT measurements. Beta-cell function...
Background Puberty is a period of rapid growth associated with metabolic, hormonal, and body composition changes that can influence risk factors for chronic diseases such as type 2 diabetes. Objective To evaluate insulin sensitivity (IS) modifications throughout puberty in large group obese Caucasian subjects. Methods Five hundred nineteen subjects (4-19 years), grouped according to gender Tanner stage (T), underwent oral glucose tolerance test. Quantitative check index (QUICKI) ISI were...
Diabetic children treated with intensive insulin therapy are showing a dangerous increase in severe hypoglycemic episodes. The Continuous Glucose Monitoring System (CGMS) allows glycemic profiles to be monitored over 72-h period. aim of the present study was evaluate whether this system is sufficiently sensitive detect asymptomatic hypoglycemia, and determine if its periodic application would help minimize risk type 1 diabetes mellitus (T1DM).Twenty-seven T1DM (age range 6-13.1 years) were...
Objective: The aim of the present study was to evaluate association between type early feeding and indices insulin metabolism in 8-year-old overweight obese children.Methods: sample included 350 (body mass index [BMI] ≥1.036 standard deviation score [SDS]) (BMI ≥1.645 SDS) children 33 normal-weight control subjects who had been exclusively breast-fed or formula-fed for 4 months longer. Parameters sensitivity secretion were derived from 120-minute oral glucose tolerance tests.Results:...
Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed identify transcriptional changes associated with progression in patients recent-onset type diabetes.Whole-blood samples were collected as part of INNODIA at baseline and 12 months after diagnosis diabetes. We used linear mixed-effects modelling on RNA-seq data genes age, sex, progression. Cell-type proportions estimated from using...
Glucokinase is essential for glucose-stimulated insulin release from the pancreatic beta-cell, serving as glucose sensor in humans. Inactivating or activating mutations of glucokinase lead to different forms disease, i.e. GCK-monogenic diabetes youth, permanent neonatal (inactivating mutations), and congenital hyperinsulinism, respectively. Here we present a novel gene (GCK)-activating mutation (p.E442K) found an infant with hypoglycemia (1.5 mmol/liter) two other family members suffering...
Telemedicine in diabetes includes telemonitoring and transmission of important data (self monitoring blood glucose data, insulin therapy, pump setting, etc.) from the patient s home to diabetic unit, with a real-time health feedback. Moreover, an eHealth approach is thought facilitate management improve compliance CSII/SAP treatment adolescents, but date, limited literature related this topic available long-term studies are still lacking. The main aim study was compare effect on...
Article A Two Year Observational Study of Nicotinamide and Intensive Insulin Therapy in Patients with Recent Onset Type I Diabetes Mellitus was published on August 1, 2005 the journal Journal Pediatric Endocrinology Metabolism (volume 18, issue 8).
Pastore A, Ciampalini P, Tozzi G, Pecorelli L, Passarelli C, Bertini E, Piemonte F. All glutathione forms are depleted in blood of obese and type 1 diabetic children. Background: Oxidative stress plays an important role the pathogenesis diabetes (T1D), where increase reactive oxygen species may contribute to initial destruction β-cells. Accumulating evidence also suggests a for oxidative obesity, it potentiate development complications. Objective: To analyze vivo homeostasis children with...