A5076772805- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Hepatitis B Virus Studies
- Adrenal and Paraganglionic Tumors
- Radiopharmaceutical Chemistry and Applications
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- DNA and Nucleic Acid Chemistry
- Hepatitis C virus research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cardiac electrophysiology and arrhythmias
- PARP inhibition in cancer therapy
- Calcium signaling and nucleotide metabolism
- Bioactive Compounds and Antitumor Agents
- Peptidase Inhibition and Analysis
- Metal complexes synthesis and properties
- Medical Imaging Techniques and Applications
- GDF15 and Related Biomarkers
- Synthesis and Biological Evaluation
- Intraperitoneal and Appendiceal Malignancies
Osaka University
2012-2024
Ishikawa Prefectural Central Hospital
2021
Nagasaki Rousai Hospital
2016
Kanazawa University
2006-2014
Kanazawa University Hospital
2006-2013
Ministry of Education, Culture, Sports, Science and Technology
2005
Hokkaido University
1984-2001
Osaka City University
1999
Osaka Hospital
1991
Purpose: To compare lesion detectability of I-123 MIBG scintigraphy with that high-dose I-131 and to evaluate incremental benefit SPECT/CT over planar image for the detection localization lesions in patients therapy malignant pheochromocytoma/paraganglioma neuroblastoma. Materials Methods: We retrospectively investigated 16 neuroblastoma, who were referred therapy. 10 pairs studies same patient, obtained within 2 weeks. In 31 17 12 patients, we compared images localization. Results: The...
A field survey was carried out soon after the Fukushima Dai-ichi Nuclear Power Plant accident. Gamma-ray emitting radionuclides and plutonium isotopes in a series of soil samples collected from heavily contaminated areas outside 20-km exclusion zone, as well Okuma Town adjacent to plant, were measured. Volatile such 131I, 134Cs, 137Cs contributed largely released radioactivity. Higher depositions these nuclides observed northwestern—including Iitate Village, which is at distance 25-45 km...
Effective treatments for malignant neuroendocrine tumors are under development. While iodine-131 metaiodobenzylguanidine (131I-MIBG) radiotherapy has been used in the treatment of tumors, there few studies evaluating its therapeutic effects and safety a multicenter cohort. In current study, we sought to evaluate 131I-MIBG therapy conditions including pheochromocytoma paraganglioma within Forty-eight (37 11 paraganglioma) from four centers underwent clinical radiotherapy. The tumor responses...
We retrospectively examined whether or not initial responses of first low-dose (131)I-meta-iodo-benzyl-guanidine radiotherapy ((131)I-MIBG therapy) in patients with malignant pheochromocytoma and paraganglioma had prognostic values.This study included 26 (n = 18) 8) who underwent the (131)I-MIBG therapy between October 2001 September 2007. Based on subjective, hormonal, scintigraphic, objective to therapy, were divided into progression disease (PD) non-PD. following factors for significance:...
Mechanisms of hepatitis B virus (HBV) reactivation after C (HCV) elimination by direct-acting antiviral (DAA) treatment in HBV/HCV-co-infected patients remain unclear. We examined RIG-I-like helicase (RLH) pathway activation HBV mono-infection, HCV mono-infection or HBV/HCV co-infection and interference between primary human hepatocytes. Interference DAA humanized-liver mice were assessed. infection activated RLH pathway, as evidenced RIG-I, ISG15 ISG56 expression induction; caused only...
Abstract There are approximately 250 million people chronically infected with hepatitis B virus (HBV) worldwide. Although HBV is often integrated into the host genome and promotes hepatocarcinogenesis, vulnerability of integration in liver cancer cells has not been clarified. The aim our study to identify factors for HBV‐associated hepatocarcinoma. Loss‐of‐function screening was undertaken HepG2 HBV‐integrated HepG2.2.15 expressing SpCas9 using a pooled genome‐wide clustered regularly...
99mTc-annexin-V imaging has been proved to be feasible detect phosphatidylserine, which externalizes on the outer cell membrane early in process of apoptosis. To determine whether postconditioning suppresses myocardial damage or apoptosis, we evaluated intensity and distribution uptake after a rat model ischemia reperfusion compared effect that ischemic preconditioning pretreatment with caspase inhibitor.In control rats (n = 13), thoracotomy left coronary artery was occluded for 20 min...
Abstract Current anti–hepatitis B virus (HBV) therapies have little effect on covalently closed circular DNA (cccDNA) and fail to eliminate HBV. The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system has been reported directly target cccDNA exert antiviral effects. In this study, we hypothesized that the inhibition of repair machinery, which is important for CRISPR‐induced double‐strand breaks, may enhance CRISPR targeting cccDNA, investigated potential combination...
Abstract Cancer cachexia, a paraneoplastic syndrome characterized by ongoing skeletal muscle mass loss, is accompanied adipose tissue loss and strongly affects chemotherapy endurance. Our aim was to detect serum marker reflecting pancreatic cancer cachexia predicting subsequent of tissue, focusing on tissue‐secreted proteins. Murine‐derived cells were orthotopically injected into the mouse tail. After 3 weeks, RNA sequencing perigonadal fat orthotopic tumors carried out. We analyzed stocked...
Background and aim In patients with a high risk of peritoneal dissemination colon cancer, treatment adjuvant to surgical resection would improve their prognosis. We aimed determine whether radioimmunotherapy employing radiolabelled monoclonal antibody work in this situation. Methods A murine model was established female Balb/c nu/nu mice by intraperitoneal injection LS180 human cancer cells. Radioimmunotherapy 7.4 MBq IgG1, anti-colorectal A7 antibody, 131I the chloramine-T method conducted...
Objective We assessed the lesion detectability of low-dose diagnostic 123I-metaiodobenzylguanidine (MIBG) whole-body scans obtained at 6 and 24 h compared with posttreatment 131I-MIBG in malignant pheochromocytoma paraganglioma. Methods Scintigrams 15 patients paraganglioma were retrospectively analyzed. Diagnostic performed 111 MBq 123I-MIBG. Therapeutic doses (5.55–7.40 GBq) administrated 2–5 days after administrations. number lesions lesion-to-referent count ratios 123I-MIBG 131I-MIBG....
We studied tumor samples from 39 patients, who entered our study January 1989 to May 1990, assess whether the ability establish a continually growing cell line fresh specimens can be associated with decreased survival times in patients small-cell lung cancer. The were used lines culture using serum-free medium supplemented hydro-cortisone, insulin, transferrin, estrogen, and selenium (HITES). Thirty-three of these obtained by fiberoptic bronchoscopy primary sites during routine diagnostic...
Iodine-131-metaiodiobenzylguanidine (131I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl recurrent neuroblastoma. The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. Although 131I-MIBG treatment did not achieve complete remission, the size of tumor reduced treatment. Based on our findings, we suggest that...
A recent approach in the treatment of limited-stage small cell lung cancer (LDSCLC) has involved a combined modality chemotherapy and chest irradiation. In using modality, study scheduling methods for combining radiotherapy should lead to other trials modalities against LDSCLC since it is most basic issue be evaluated. We have thus conducted multicenter phase II trial concurrent cisplatin-etoposide (PVP) determine effects administration PVP regimen irradiation on response rate, relapse,...
Capsid allosteric modulators (CAMs) inhibit the encapsidation of hepatitis B virus (HBV) pregenomic RNA (pgRNA), which contains a pathogen‐associated molecular pattern motif. However, effect CAMs on innate immune response HBV‐infected hepatocytes remains unclear, and we examined this in study. Administration CAM compound, BAY41‐4109 (BAY41), to primary human (PHHs) did not change total cytoplasmic pgRNA levels but significantly reduced intracapsid levels, suggesting that BAY41 increased...
Abstract Aim Patients with chronic hepatitis B (CHB) remain at risk for hepatocellular carcinoma (HCC) even nucleos(t)ide analog therapy. We evaluated factors HCC development, including serum virus (HBV) RNA, core‐related antigen level, and growth differentiation factor 15 (GDF15) a predictor of development in patients C. Methods collected clinical data stored from CHB without history who were receiving treatment more than 1 year whose HBV DNA level was less 3.0 log IU/mL. measured the...
The current study aimed to determine the efficacy of radioiodine-131 ((131)I) ablation therapy with thyroid hormone replacement one day before (131)I administration in patients well-differentiated cancer (DTC).This retrospective included 29 who underwent therapies twice for DTC during 6-12 months. Since all obviously had residual lesions by their serum thyroglobulin levels or scintigrams at first therapies, they second without diagnostic scintigraphy after therapies. After confirming...