A5012960163- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Systemic Lupus Erythematosus Research
- Mitochondrial Function and Pathology
- Acute Lymphoblastic Leukemia research
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sphingolipid Metabolism and Signaling
- Circadian rhythm and melatonin
- Atherosclerosis and Cardiovascular Diseases
- Full-Duplex Wireless Communications
- Autoimmune and Inflammatory Disorders Research
- Migraine and Headache Studies
- Cytokine Signaling Pathways and Interactions
- Pregnancy and Medication Impact
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Nigella sativa pharmacological applications
- ATP Synthase and ATPases Research
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 and healthcare impacts
Universidade Federal Fluminense
2019-2021
Universidade Estadual de Campinas (UNICAMP)
2003-2021
Pontifícia Universidade Católica de Campinas
2019
Faculdade de Medicina de Jundiaí
2012-2018
Cognitive Neuroimaging Lab
2017
The mechanisms guiding the progression of neuronal damage in patients with Huntington disease (HD) are not completely understood. It is unclear whether genotype--that is, length expanded CAG repeat--guides location and speed grey matter decline once HD clinically manifested. Moreover, relationship between cortical subcortical atrophy severity motor symptoms controversial.In this article, we longitudinally studied, over period 1 year, a cohort 49 HD. We investigated: first, clinical relevance...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects the striatum most severely. However, except for juvenile forms, relative preservation of cerebellum has been reported. The objective present study was to perform MRI measurements caudate, putamen, cerebral, and cerebellar volumes correlate these findings with length CAG repeat clinical parameters. We evaluated 50 consecutive patients HD using volumetric compared them normal controls. Age at onset...
<h3>Background and Objectives</h3> To describe the clinical features disease outcomes of coronavirus 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorder (NMOSD). <h3>Methods</h3> The Neuroimmunology Brazilian Study Group has set up report severe acute respiratory syndrome (SARS-CoV2) cases NMOSD (pwNMOSD) using a designed web-based case form. All neuroimmunology outpatient centers individual neurologists were invited to register their across country. Data collected...
Little information is available regarding the incidence and clinical outcome of SARS-CoV2 infection in patients with multiple sclerosis (pwMS).To determine incidence, outcome, impact COVID-19 on pwMS.This observational study was prospectively performed a cohort pwMS (N = 11,560) followed up by 47 out 51 Brazilian MS referral centers that registered at REDONE platform from 13 March to 4 June 2020.The for 27.7/10,000 general population 29.2/10,000 inhabitants. A total 94 (77 women) patients,...
OBJECTIVE: To describe the clinical presentation a group of patients with juvenile onset Huntington disease. METHOD: All were interviewed following structured questioner. Patients genotyped for trinucleotide cytosine-adenine-guanine (CAG) repeat in Disease gene. High resolution brain MRI was performed all patients. RESULTS: We identified 4 disease among 50 followed prospectively our Neurogenetics clinic. Age at varied from 3 to 13 years, there 2 boys, and had paternal inheritance Expanded...
Immunotherapy with Interferon-beta (IFNbeta) results in remarkably beneficial effects patients relapsing-remitting multiple sclerosis (MS), although the mechanisms by which it exerts these remain poorly understood. An investigation was made of IFNbeta on pro-inflammatory and anti-inflammatory cytokine production peripheral blood cells MS patients, both untreated those undergoing immunotherapy, as well healthy controls. Results show a significant increase cytokines such TNFalpha, IFNgamma...
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system. NMOSD starting after age 50 years considered a "late onset" (LO-NMOSD) and seems to be particularly aggressive. The objective this paper present series 37 Brazilian patients with LO-NMOSD. Retrospective data collection from medical records LO-NMOSD seen at 14 specialized units. ratio women men in sample was 4.3 1. were followed up for median period 4 years. Sex, onset, ethnic...
Our objective was to investigate thalamic neuronal dysfunction in patients with Huntington disease (HD). We performed localized single-voxel proton magnetic resonance spectroscopy (MRS) of the thalamus 22 HD and 25 healthy individuals. The mean age 48.5 years (ranging from 32 71 years). Age at onset varied between 20 66 (mean 38.9 expanded CAG repeat ranged 40 52 45.2) CAGs. control group 35.4 years, ranging 19 67 years. N-acetylaspartate (NAA) relative creatine (NAA/Cr) values were...
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ABSTRACT Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and Disability Assessment questionnaire can evaluate disease burden. aim present study was assess presence migraine in with MS. Methods: Patients diagnosed MS attending specialized units were invited answer an online survey if they also experienced headache. Results: included 746 complete responses There 625 women 121 men, 69% all aged between 20...
Brain white matter lesions found upon magnetic resonance imaging are often observed in psychiatric or neurological patients. Individuals with these present a more significant cognitive impairment when compared individuals without them. We propose computerized method to distinguish tissue containing of different etiologies (e.g., demyelinating ischemic) using texture-based classifiers. Texture attributes were extracted from manually selected regions interest and used train test supervised...
Cytokines and intrathecal IgG synthesis were determined in the cerebrospinal fluid (CSF) sera to evaluate inflammatory activity multiple sclerosis (MS) patients during clinical remission. Although disease was stable, there had been a significant increase of proinflammatory cytokines such as TNFalpha IFNgamma CSF serum, with no changes IL12 IL10 production. The cytokine production patterns associated an leukocytes CSF, well presence oligoclonal bands suggesting synthesis. These results...
Multiple sclerosis (MS) is a chronic inflammatory disease of the white matter central nervous system (CNS) characterized by focal areas demyelination. Interferon-β (IFN-β) provides an effective treatment that lessens frequency and severity exacerbations in relapsing-remitting multiple (RRMS), but mechanisms which IFN-β efficient remain uncertain. The data presented here demonstrate impairs proliferative response to myelin basic protein (MBP) myelin, as well increasing expression CTLA4...
BACKGROUND: Fampridine is a broad-spectrum voltage-dependent potassium channel blocker that enhances synaptic transmission. The drug has been shown to be able ameliorate conduction in demyelinated axons, thereby leading improved gait patient
Multiple sclerosis (MS) is a chronic, neurological, immune-mediated disease that can worsen in the postpartum period. There no consensus on use of immunoglobulin for prevention relapses after delivery. We have shown controversial beneficial effect given immediately birth could not be observed patients with MS.
Alexithymia is a personality trait characterized by difficulties identifying and describing feelings. Some researchers describe high levels of alexithymia among patients with multiple sclerosis (MS) but literature data on this subject are scarce.The objective the present study was to characterize findings in MS.This cross-sectional case-control included 180 MS matched control group. Data for disease duration, number demyelinating relapses degree neurological disability, as assessed Expanded...
To assess the prevalence and profile of adverse events (AE) natalizumab in patients with multiple sclerosis (MS).Data collection from neurologists attending to MS at specialized units Brazil.Data 103 infusion centers 16 9 Brazilian states were included study. The total number infusions was 1,042. Seventy-nine (76.7%) did not present any AE. Twenty-four (23.3%) presented only mild There three major AE, including two deaths. These occurrences, although necessarily being drug-related, must be...
Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use this drug has created need better comprehension JC virus (JCV) infection. objective present study was to assess prevalence JCV-DNA in Brazilian patients using natalizumab.Qualitative detection JCV serum performed with real-time polymerase chain reaction (PCR).In group 168 MS who were undergoing natalizumab, detectable 86 (51.2%)...
We evaluated the cerebrospinal fluid (CSF) cytokine profile and magnetic resonance imaging (MRI) findings in systemic lupus erythematosus (SLE) patients with central nervous system (CNS) involvement.Consecutive SLE followed at rheumatology unit were enrolled into this study. Neurologically asymptomatic controls matched for age sex recruited during myelography. assessed disease activity (Systemic Lupus Erythematosus Disease Activity Index; SLEDAI) cumulative damage International Collaborating...
Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective the present study was to assess serum vitamin levels a large population patients with MS controls living restricted tropical area.Data from 535 350 control subjects were obtained 14 cities around Tropic Capricorn.The mean 25-OH level 26.07 ± 10.27 ng/mL for subjects, 28.03 12.19 MS. No correlation observed between disability over disease duration.At least region Capricorn, typically are...
The Scientific Department of Neuroimmunology the Brazilian Academy Neurology (DCNI/ABN) and Committee for Treatment Research in Multiple Sclerosis Neuroimmunological Diseases (BCTRIMS) provide recommendations this document vaccination population with demyelinating diseases central nervous system (CNS) against infections general severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize seriousness current situation view spread COVID-19 our country....