A5043249566- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Bariatric Surgery and Outcomes
- Glycosylation and Glycoproteins Research
- COVID-19 Impact on Reproduction
- Venous Thromboembolism Diagnosis and Management
- Viral-associated cancers and disorders
- Pregnancy-related medical research
- Maternal and Perinatal Health Interventions
- Ocular Surface and Contact Lens
- T-cell and Retrovirus Studies
- Salivary Gland Disorders and Functions
- Blood Coagulation and Thrombosis Mechanisms
- Body Contouring and Surgery
- SARS-CoV-2 and COVID-19 Research
- Platelet Disorders and Treatments
- Preterm Birth and Chorioamnionitis
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Maternal and fetal healthcare
- Genetic factors in colorectal cancer
University of Haifa
2021-2025
Mayo Clinic
2017-2024
Mayo Clinic in Florida
2016-2024
Mayo Clinic in Arizona
2017-2022
Hadassah Medical Center
2015-2021
Hebrew University of Jerusalem
2016-2019
Hudson Institute
2018
John Wiley & Sons (United States)
2018
RELX Group (United States)
2018
Philadelphia University
2018
Fresh water scarcity has led to increased use of reclaimed wastewater as an alternative and reliable source for crop irrigation. Beyond microbiological safety, concerns have been raised regarding contamination by xenobiotics including pharmaceuticals. This study focuses on carbamazepine, anticonvulsant drug which is ubiquitously detected in wastewater, highly persistent soil, taken up crops. In a randomized controlled trial we demonstrate that healthy individuals consuming...
Coronavirus disease 2019 (COVID-19) during pregnancy and early infancy can result in severe disease. Evaluating the effect of gestational age at time acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on maternal antibody levels transplacental transfer has important implications for care strategies.Maternal cord blood sera were collected from mother-newborn dyads (n = 402), following term delivery after antenatal 2-dose SARS-CoV-2 BNT162b2 mRNA vaccination. spike protein (S)...
OBJECTIVE: To examine associations of laparoscopic sleeve gastrectomy with maternal and perinatal outcomes. METHODS: We conducted a retrospective case–control study deliveries that occurred from 2006 to 2016 at two university hospitals. The group comprised all women who had undergone delivered during the period. If woman more than one pregnancy period, data only her first were used. A control was established by matching preoperative body mass index (BMI), age, parity, delivery history, year....
Abstract Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal disorder that progresses to multiple myeloma (MM), or other plasma-cell lymphoid disorders at rate 1%/year. We evaluate the contribution body mass index (BMI) MGUS progression beyond established clinical factors in population-based study. identified 594 through screening study Olmsted County, Minnesota, between 1995 and 2003. Follow-up time was calculated from date last follow-up, death, MM/another...
Monoclonal B-cell lymphocytosis (MBL) is a common hematological premalignant condition that understudied in screening cohorts. MBL can be classified into low-count (LC) and high-count (HC) types based on the size of clone. Using Mayo Clinic Biobank, we screened for evaluated its association with future hematologic malignancy overall survival (OS). We had two-stage study design including discovery validation using an eight-color flow-cytometry assay. Medical records were abstracted cancers...
Abstract TP53 aberrations, including mutations and deletion of 17p13, are important adverse prognostic markers in chronic lymphocytic leukemia (CLL) but less studied high count monoclonal B-cell lymphocytosis (HCMBL), an asymptomatic pre-malignant stage CLL. Here we estimated the prevalence impact aberrations 1,230 newly diagnosed treatment-naïve individuals (849 CLL, 381 HCMBL). We defined state as: wild-type (no normal 17p), single-hit (del(17p) or one mutation), multi-hit (TP53 mutation...
Diffuse large B-cell lymphoma (DLBCL) is clinically heterogeneous, and gene expression profiling has identified at least two biologically distinct DLBCL subtypes defined by their cell-of-origin (COO): germinal center (GCB) activate (ABC) or non-GCB. We evaluated a variety of putative risk factors for etiologic heterogeneity COO in clinic-based study newly diagnosed cases (N=638) frequency-matched controls (N=2253). was determined on formalin-fixed, paraffin-embedded tumor tissue, with...
Abstract Autoimmune conditions are strong risk factors for developing lymphoma, but their role in lymphoma prognosis is less clear. In a prospective cohort study, we evaluated self-reported history of eight autoimmune with outcomes 736 diffuse large B-cell, 703 follicular, 302 marginal zone (MZL), 193 mantle cell (MCL), 297 Hodgkin (HL), and 186 T-cell lymphomas. We calculated event-free survival (EFS) overall (OS), estimated hazard ratios (HRs) 95% confidence intervals (CIs), adjusting sex,...
We evaluated the role of 18-fluoro-2-deoxy-d-glucose positron emission tomography ([18F] FDG-PET) with computed (CT) (PET/CT) as a diagnostic and prognostic tool in newly diagnosed marginal zone lymphoma (MZL) patients. This is retrospective cohort study patients MZL, treated immunotherapy, chemotherapy regimens, surgery, or Helicobacter pylori eradication between 2008 2016 single tertiary center. Only who had pretreatment PET/CT (P-PET/CT) were included. P-PET/CT, interim (I-PET/CT),...
Next-generation sequencing identified about 60 genes recurrently mutated in chronic lymphocytic leukemia (CLL). We examined the additive prognostic value of total number CLL (i.e., tumor mutational load [TML]) or individually beyond international index (CLL-IPI) newly diagnosed and high-count monoclonal B-cell lymphocytosis (HC MBL). sequenced 59 among 557 individuals (112 HC MBL/445 CLL) a multi-stage design, to estimate hazard ratios (HR) 95% confidence intervals (CI) for time-to-first...
ABSTRACT Objective Cervical cerclage, when performed in twin gestation, has been reported to be associated with poor outcome. However, the role of first‐trimester history‐indicated cerclage among women a pregnancy and history preterm birth not evaluated. The aim this study was assess outcomes who underwent cervical compared those managed expectantly. Methods This retrospective matched case–control study. group comprised all had undergone during period 2006 2017 at Hadassah‐Hebrew University...