A5002145140- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Single-cell and spatial transcriptomics
- Photosynthetic Processes and Mechanisms
- HVDC Systems and Fault Protection
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Technology Adoption and User Behaviour
- Plant Reproductive Biology
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Facilities and Workplace Management
- Consumer Retail Behavior Studies
- Cyberloafing and Workplace Behavior
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
Third Xiangya Hospital
2015-2023
Central South University
2015-2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2023
Xiangya Hospital Central South University
2023
Sun Yat-sen University Cancer Center
2018-2022
Sun Yat-sen University
2018-2022
Baidu (China)
2022
State Key Laboratory of Oncology in South China
2021
Huazhong Agricultural University
2017-2020
The N6-methyladenosine (m6A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated decay (NMD) whether NMD detects induced carcinogenesis pathways remain undefined. Here, we showed that the m6A methyltransferase METTL3 sustained oncogenic role by modulating of splicing factors alternative isoform switches glioblastoma (GBM). Methylated RNA immunoprecipitation-seq (MeRIP-seq) analyses peaks were enriched at pathway-related...
Summary Multilocular silique is a desirable agricultural trait with great potential for the development of high‐yield varieties Brassica . To date, no spontaneous or induced multilocular mutants have been reported in napus , which likely reflects its allotetraploid nature and extremely low probability simultaneous random mutagenesis multiple gene copies functional redundancy. Here, we present evidence efficient knockout rapeseed homologues CLAVATA 3 ( CLV ) secreted peptide related receptors...
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional modification in mammalian mRNA molecules and has a crucial function regulation of many fundamental biological processes. The m6A dynamic reversible process regulated by series writers, erasers readers (WERs). Different WERs might have different functions, even same WER differently conditions, which are mostly due to downstream genes being targeted WERs. Therefore, identification targets particularly important for...
Immunotherapy is a promising cancer treatment method; however, only few patients benefit from it. The development of new immunotherapy strategies and effective biomarkers response resistance urgently needed. Recently, high-throughput bulk single-cell gene expression profiling technologies have generated valuable resources. However, these resources are not well organized systematic analysis difficult. Here, we present TIGER, tumor resource, which contains transcriptome data 1508 samples with...
Circular RNAs (circRNAs) have been shown to be closely linked the tumorigenesis and treatment response of hematological malignancies. However, biological functions clinical implications circRNAs in acute myeloid leukemia (AML) remain largely unknown. CircRNA microarray datasets were analyzed screen differentially expressed AML patients. It was found that circZBTB46 significantly upregulated patients cells. Moreover, expression associated with stages showed high sensitivity specificity for...
Abstract The early detection of cancer holds the key to combat and control increasing global burden morbidity mortality. Blood-based screenings using circulating DNAs (ctDNAs), RNA (ctRNAs), tumor cells (CTCs) extracellular vesicles (EVs) have shown promising prospects in cancer. Recent high-throughput gene expression profiling blood samples from patients has provided a valuable resource for developing new biomarkers However, well-organized online repository these blood-based data is still...
Nowadays, working from home (WFH) has become a popular work arrangement due to its many potential benefits for both companies and employees (e.g., increasing job satisfaction retention of employees). Many previous studies have investigated the impact on productivity employees. However, most these usually use qualitative analysis method such as survey interview, studied participants do not long continuing time. Due outbreak coronavirus disease 2019 (COVID-19), large number asked their home,...
MicroRNAs (miRNAs) and their target genes have been shown to play an important role in gastric cancer but not fully clarified. Therefore, our goal was identify the key miRNA-mRNA regulatory network by utilizing a variety of bioinformatics analyses experiments. A total 242 miRNAs 1080 were screened from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), respectively. Then, survival-related differentially expressed screened. Twenty hub identified protein-protein interaction network....
N6-methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells and play critical roles cancer. While related studies focus on m6A modifications linear RNA, transcriptome-wide profiling exploration circular RNAs cancer still lacking.For detection circRNAs, we developed a new bioinformatics tools called Circm6A applied it to m6A-seq data 77 tissue samples from 58 individuals with pancreatic ductal adenocarcinoma (PDAC).Circm6A performs better than existing circRNA...
Abstract The CLE ( CLAVATA3 / ESR ) gene family, encoding a group of small secretory peptides, plays important roles in cell‐to‐cell communication, thereby controlling broad spectrum development processes. family has been systematically characterized some plants, but not Brassica napus . In the present study, 116 BnCLE genes were identified B. genome, including seven unannotated, six incorrectly predicted and five multi‐CLE domain‐encoding genes. These members separated into distinct groups...
Abstract Immunotherapy is a promising cancer treatment method, but only few patients benefit from it. Developing new immunotherapy strategies and effective biomarkers of response resistance urgent. Recent high-throughput bulk single-cell gene expression profiling technologies have generated valuable resources in these regards. However, are not well organized systematic analysis difficult. Here, we present TIGER, tumor resource, which contains transcriptome data 1508 samples with clinical...
Abstract Summary MeRIPseqPipe is an integrated and automatic pipeline that can provide users a friendly solution to perform in-depth mining of MeRIP-seq data. It integrates many functional analysis modules, range from basic processing downstream analysis. All the processes are embedded in Nextflow with Docker support, which ensures high reproducibility scalability particularly suitable for analyzing large number samples at once simple command. The final output directory structured based on...
Unsupervised clustering of high-throughput gene expression data is widely adopted for cancer subtyping. However, subtypes derived from a single dataset are usually not applicable across multiple datasets different platforms. Merging necessary to determine accurate and but still embarrassing due the batch effect. CrossICC an R package designed unsupervised datasets/platforms without requirement effect adjustment. utilizes iterative strategy derive optimal signature cluster numbers consensus...
<p>Supplementary Figures and Methods</p>
<p>Supplementary Figures and Methods</p>
<div>Abstract<p>The N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated decay (NMD) whether NMD detects induced carcinogenesis pathways remain undefined. Here, we showed that the m<sup>6</sup>A methyltransferase METTL3 sustained oncogenic role by modulating of splicing factors alternative isoform switches glioblastoma (GBM)....
<div>Abstract<p>The N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated decay (NMD) whether NMD detects induced carcinogenesis pathways remain undefined. Here, we showed that the m<sup>6</sup>A methyltransferase METTL3 sustained oncogenic role by modulating of splicing factors alternative isoform switches glioblastoma (GBM)....
Abstract Background: The importance of amino acid metabolism in multiple cancers was investigated by accumulating researches. But the role metabolism-related genes (AAMRGs) played colorectal cancer (CRC) progression remains unclear. Methods: clinical information and RNA sequencing CRC were acquired from Cancer Genome Atlas (TCGA) databases Gene Expression Omnibus (GEO) databases, metabolic gene data downloaded a published article journal Cell Reports. Cox-LASSO analysis adopted to establish...
Background: The importance of amino acid metabolism in cancers was confirmed, however, the role metabolism-related genes (AAMRGs) played colorectal cancer (CRC) progression remains unclear. Methods: Cox-LASSO analysis adopted to establish AAMRG prognostic signature. validation 10-AAMRG signature both bioinformatics analyses and experiment. Moreover, gene set enrichment (GSEA) further investigation immune infiltration, somatic mutation, drug sensitivity EMT conducted based on GSEA result....