Ondřej Strouhal
A5082189282- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Tryptophan and brain disorders
- HIV/AIDS drug development and treatment
- Intensive Care Unit Cognitive Disorders
- Pancreatic function and diabetes
- Cancer survivorship and care
- Advanced Proteomics Techniques and Applications
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Galectins and Cancer Biology
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Photosynthetic Processes and Mechanisms
- Ovarian cancer diagnosis and treatment
- Pharmacological Effects and Toxicity Studies
- Mitochondrial Function and Pathology
- Renal cell carcinoma treatment
- Music Therapy and Health
- Glycosylation and Glycoproteins Research
- Viral Infections and Vectors
- Cancer-related Molecular Pathways
- Nanopore and Nanochannel Transport Studies
Palacký University Olomouc
2011-2023
University Hospital Olomouc
2017-2023
Institute of Molecular and Translational Medicine
2018-2021
Charles University
2021
Cancer Institute (WIA)
2021
Czech Academy of Sciences, Institute of Experimental Medicine
2021
Summary Cyclic electron transport ( CET ) around photosystem I PSI plays an important role in balancing the ATP / NADPH ratio and photoprotection of plants. The NAD(P)H dehydrogenase complex NDH has a key function one pathways. Current knowledge indicates that, order to fulfill its , needs be associated with ; however, until now there been no direct structural information about such supercomplex. Here we present data obtained for plant – Electron microscopy analysis revealed that this...
Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed advanced phases, resulting very high mortality. Tools to identify individuals at risk developing PDAC would be useful improve chances detection. Objective We generated a polygenic score (PRS) for prediction, combining effect known SNPs, carried out an exploratory analysis multifactorial score. Methods tested associations individual SNPs on up 2851 4810...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes cancer-related deaths worldwide, accounting for 90% primary pancreatic tumors with an average 5-year survival rate less than 10%. PDAC exhibits aggressive biology, which, together late detection, results in patients presenting unresectable, locally advanced, or metastatic disease. In-depth lipid profiling and screening potential biomarkers currently appear to be a promising approach early detection other cancers. Here,...
DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in design new strategies treatments, prevention platinum-based chemoresistance, prolongation overall patient survival not only with respect to ovarian cancer. The role hyperthermic intraperitoneal chemotherapy (HIPEC) together cytoreductive surgery (CRS) adjuvant systemic is receiving more interest cancer (OC) treatment because typical peritoneal spread disease....
Abstract Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival pancreatic cancer patients. This study tested whether genetic variability in associates risk and prognosis. Twenty four single nucleotide polymorphisms (SNPs) tagging sequence regulatory elements were selected for analysis. Of these, 22 successfully evaluated discovery phase while six significant or suggestive variants entered validation phase, comprising a total number 1,518 cases...
Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much the heritability risk remains unidentified. A recessive genetic model could be a powerful tool for identifying additional variants. To discover recessively inherited loci, we performed re-analysis largest GWAS, Pancreatic Cancer Cohort Consortium (PanScan) and Case-Control (PanC4), including 8,769 cases 7,055 controls ancestry. Six...
Pancreatic ductal adenocarcinoma (PDAC) is a tumor with poor prognosis, and no targeted therapy currently available. The aim of the present study was to investigate prognostic significance expression V‑Ki‑ras2 Κirsten rat sarcoma viral oncogene homolog (KRAS), downstream signaling pathway genes association clinical characteristics in PDAC patients undergoing radical surgery. Tumors adjacent non‑neoplastic pancreatic tissues were examined 45 histologically verified PDAC. KRAS B‑Raf...
The principal aim of this report was to study second primary malignant neoplasms (SMNs) in long-term survivors pancreatic ductal adenocarcinoma (PDAC) with regard the germline genetic background.A total 118 PDAC patients after a curative-intent surgery who were treated between 2006 and 2011 analyzed. Of 22 surviving for >5 years, six went on develop SMNs. A analysis 219 hereditary cancer-predisposition candidate genes performed by targeted next-generation sequencing DNA from 20 these...
Abstract The KRAS signalling pathway is pivotal for pancreatic ductal adenocarcinoma (PDAC) development. After the failure of most conventional cytotoxic and targeted therapeutics tested so far, combination taxane nab-paclitaxel (Abraxane) with gemcitabine recently demonstrated promising improvements in survival PDAC patients. This study aimed to explore interactions paclitaxel experimental SB-T-1216 expression vivo vitro models order decipher potential predictive biomarkers or targets...
Abstract The aim of this study was to investigate the changes in circulating concentrations citrulline, neopterin, kynurenine, and tryptophan during course chemoradiation patients with cervical cancer. Sixteen histologically confirmed carcinoma uterine cervix, aged 53 ± 15 years (range 29–76 years), were included study. Plasma determined an enzyme-linked immunosorbent assay. citrulline measured high-performance liquid chromatography. Compared baseline, concentration markedly statistically...