A5082753633- Frailty in Older Adults
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Hip and Femur Fractures
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Intensive Care Unit Cognitive Disorders
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac electrophysiology and arrhythmias
- Advanced Glycation End Products research
- Anesthesia and Neurotoxicity Research
- Coronary Interventions and Diagnostics
- Non-Invasive Vital Sign Monitoring
- Muscle Physiology and Disorders
- Vascular anomalies and interventions
- Alcoholism and Thiamine Deficiency
- Renin-Angiotensin System Studies
- Sex and Gender in Healthcare
Juntendo University
2018-2025
Juntendo University Nerima Hospital
2023-2024
Juntendo University Hospital
2018
Juntendo University Shizuoka Hospital
2016
Aim We examined the changes in oxidative stress, mitochondrial function and muscle atrophy during aging mice. Methods used 6‐, 12‐ 24‐month (6 M, 12 M 24 M)‐old C57BL/6J Skeletal muscles were removed from lower limb for quantitative real‐time polymerase chain reaction, immunoblotting histological analyses. Results The weight myocyte cross‐sectional area significantly decreased mice compared with those of 6 levels stress markers, nicotinamide adenine dinucleotide phosphate oxidase 2, 4,...
The advanced glycation end products (AGEs), which can be assessed through skin autofluorescence (SAF), have been linked to chronic kidney disease (CKD), diabetes mellitus (DM), and aging. However, it is unknown how frailty SAF levels are associated with cardiovascular (CVD). We enrolled 1,000 consecutive CVD patients who participated in phase II cardiac rehabilitation (CR) underwent assessment of between November 2015 September 2017 at Juntendo University Hospital. Of these, 48 were excluded...
Background: Delirium is a common occurrence in patients admitted to the intensive care unit and related mortality morbidity. Malnutrition predisposing factor for development of delirium. Nevertheless, whether nutritional status on admission anticipates delirium with acute cardiovascular diseases remains unknown. Objective: This study aims assess correlation between using index coronary unit. Design: We examined 653 consecutive (mean age: 70 ± 14 years) Juntendo University Hospital January...
Cardiac rehabilitation (CR) is an established multidisciplinary secondary preventive program. We investigated the effects of CR involving intensive physical activity (PA) on coronary plaque volume and components in patients with acute syndrome (ACS).
Abstract Background Advanced glycation end-products, indicated by skin autofluorescence (SAF) levels, could be prognostic predictors of all-cause and cardiovascular mortality in patients with diabetes mellitus (DM) renal disease. However, the clinical usefulness SAF levels heart failure (HF) who underwent cardiac rehabilitation (CR) remains unclear. This study aimed to investigate associations between MACE risk HF CR. Methods enrolled 204 consecutive had undergone CR at our university...
Background: Muscle wasting is a debilitating phenotype associated with chronic heart failure. We have previously demonstrated that angiotensin II (AII) directly induces muscle in mice through the activation of NADPH oxidase. In this study, we tested hypothesis deficiency oxidase 4 (Nox4), major source oxidative stress, ameliorates AII-induced regulation redox balance. Methods and Results: Nox4 knockout (KO) wild-type (WT) were used. At baseline, there no differences physical characteristics...
The Kihon Checklist is a useful screening tool for assessing frailty in older individuals. However, the clinical significance of cardiac rehabilitation patients remains unclear. present study aimed to evaluate relationship between and parameters who participated rehabilitation.We enrolled 845 consecutive (584 men, mean age 71 years) at Juntendo University Hospital, Tokyo, Japan, November 2015 October 2017. were divided into non-frailty (n = 287), pre-frailty 270) 288) groups according their...
Abstract Background Advanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, relationship between SAF levels exercise capacity in patients cardiovascular disease (CVD) remains unclear. This study aimed to investigate association tissue clinical characteristics, including capacity, CVD. Methods We enrolled 319 consecutive CVD aged ≥40 years...
Cardiac rehabilitation (CR) is categorized as a class I recommendation in the guidelines for management of patients with cardiovascular disease (CVD). However, penetration rate outpatient CR low Japan. We designed pilot study to evaluate safety and feasibility tele-CR using remote biological signal monitoring system.
Arterial stiffness contributes to the development of cardiovascular disease (CVD). However, relationship between arterial and exercise tolerance in CVD patients with preserved ejection fraction (pEF) those reduced EF (rEF) is unclear. We enrolled 358 who participated cardiac rehabilitation underwent cardiopulmonary testing at Juntendo University Hospital. After excluding 195 had undergone open heart surgery 20 mid-range EF, were divided into pEF (n = 99) rEF 44) groups. was assessed using...
The frailty state consists of not only physical but also psycho-emotional problems, such as cognitive dysfunction and depression well social problems. However, few reports have examined the relationship between anxiety levels in elderly patients undergoing cardiac rehabilitation (CR).We analyzed 255 (mean age: 74.9 ± 5.8 years, 67% male) who participated early phase II CR at Juntendo University Hospital. At beginning CR, carried out self-assessments based on Kihon Checklist (KCL) State Trait...
Follistatin-like 1 (FSTL1) is a glycoprotein secreted by skeletal muscle cells and cardiac myocytes. Previous studies showed that serum FSTL1 concentrations were increased in acute coronary syndrome chronic heart failure. The aim of this study was to assess the associations among plasma concentration, clinical parameters, whether concentration could predict cardiovascular events patients with elective percutaneous intervention (PCI).A consecutive series 410 who underwent PCI drug-eluting...
Peak oxygen uptake (peak VO2 ) and heart rate reserve (HRR) are independent prognostic markers of cardiovascular disease. However, the impact peak HRR on long-term prognosis after off-pump coronary artery bypass grafting (OP-CABG) remains unclear.To determine in patients OP-CABG.We enrolled 327 (mean age, 65.1 ± 9.3 years; male, 80%) who underwent OP-CABG participated early phase II cardiac rehabilitation. All participants cardiopulmonary exercise testing (CPET) at beginning such Overall, 48...
The Japanese Ministry of Health, Labour and Welfare reported that the overall constipation complaint rates among men women are 2.5% 4.6%, respectively. To evaluate impact on patients with cardiovascular diseases, we investigated association between frailty components in undergoing cardiac rehabilitation (CR).We enrolled 102 consecutive late phase II CR (mean age: 62.7 ± 13.4 years; 68 (67%) were men). We clinical characteristics, observed defecation status evaluated assessed by Kihon...
Abstract Background Despite the positive impact of implantable cardioverter defibrillators (ICDs) and wearable (WCDs) on prognosis, their implantation is often withheld especially in Japanese heart failure patients with reduced left ventricular ejection fraction (HFrEF) who have not experienced tachycardia (VT) or fibrillation (VF) for uncertain reasons. Recent advancements (HF) medications significantly improved prognosis HFrEF. Given this context, a critical reassessment treatment ICDs...
Takotsubo cardiomyopathy (TCM) leads to serious left ventricular outflow tract (LVOT) obstruction with cardiogenic shock in 6%–20% of cases. The onset LVOT obstruction, coupled mitral regurgitation resulting from systolic anterior motion valve leaflets, can lead haemodynamic instability addition severely impaired function. We describe three patients who experienced chest discomfort following emotional stress. These displayed pronounced abnormalities on ECGs, insignificant obstructive...
Background: Frailty is an important prognostic factor in patients with cardiovascular diseases (CVD), and CVD have a high rate of concurrent psycho-emotional stress, as well depressive mood anxiety symptoms. Despite this, few reports examined the effects efficacy Phase II cardiac rehabilitation (CR) frail patients, including improvements levels. Methods Results: In all, 137 (mean [±SD] age 65.8±13.0 years; 71% male) who participated CR were assessed after completion included this study....
Malnutrition impairs quality of life and prognosis patients with cardiovascular disease. The Mini Nutritional Assessment (MNA) is a screening tool developed for the nutritional assessment older adults. However, usefulness MNA undergoing cardiac rehabilitation (CR) has not been fully investigated.From March 2017 to September 2019, MNA-short form (MNA-SF) total score in phase II CR at Juntendo University Hospital were evaluated.A 336 (mean age 70.1 ± 11.4 years; males: 209) analyzed. In...
Abstract Funding Acknowledgements Type of funding sources: None. Background With an aging cardiovascular disease population, frailty is become important prognostic factor in patients, which associated with poor quality life outcomes, such as fatigue, and decreased physical activity. However, the relationship between health-related (HRQOL) elderly patients undergoing cardiac rehabilitation (CR) remains unclear. Methods In this study, 217 (mean age: 74.6 ± 5.8 years; male: 67%) were recruited...