Lin Chen

ORCID: 0000-0002-4821-1216
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Cardiac electrophysiology and arrhythmias
  • Blood Pressure and Hypertension Studies
  • Cardiac Imaging and Diagnostics
  • Head and Neck Cancer Studies
  • Inflammatory Biomarkers in Disease Prognosis
  • Cardiovascular Disease and Adiposity
  • Cardiac pacing and defibrillation studies
  • Esophageal Cancer Research and Treatment
  • Venous Thromboembolism Diagnosis and Management
  • Cardiac Fibrosis and Remodeling
  • Hemodynamic Monitoring and Therapy
  • Cardiovascular Function and Risk Factors
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Health Systems, Economic Evaluations, Quality of Life
  • Nutrition and Health in Aging
  • Cardiovascular Health and Disease Prevention
  • Cancer Immunotherapy and Biomarkers
  • Acute Myocardial Infarction Research
  • Cancer-related molecular mechanisms research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Ferroptosis and cancer prognosis
  • Cardiomyopathy and Myosin Studies
  • Acute Ischemic Stroke Management

Third Affiliated Hospital of Guangzhou Medical University
2025

Guangzhou Medical University
2025

Soochow University
2024

Suzhou Municipal Hospital
2024

Songjiang District Central Hospital
2024

University of Minnesota System
2024

Fujian Provincial Hospital
2016-2024

Guangdong Medical College
2024

Fujian Medical University
2010-2023

Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023

Atrial fibrillation (AF) is the most common persistent cardiac arrhythmia. This study aimed to estimate its prevalence and explore associated factors in adults aged 18 years or older China.Study data were derived from a national sample July 2020 September 2021. Participants recruited using multistage stratified sampling method twenty-two provinces, autonomous regions, municipalities China. AF was determined based on history of diagnosed electrocardiogram results.A total 114,039 respondents...

10.1016/j.lanwpc.2022.100439 article EN cc-by-nc-nd The Lancet Regional Health - Western Pacific 2022-04-11

To evaluate and compare the prognostic performance of four nutritional indicators body mass index (BMI), serum albumin (ALB), (PNI) risk (NRI) in oral cancer patients, to predict response chemotherapy patients with different status.This prospective study which involved 1395 was conducted Fujian, China from September 2007 November 2018. The BMI, PNI NRI were calculated according following formulas: BMI = weight / height2 (kg/m2), (g/l) + 0.005 × lymphocyte (count/μl) (1.519 albumin, g/l)...

10.1186/s12885-020-6604-2 article EN cc-by BMC Cancer 2020-02-22

Objective: To explore the clinical manifestation, diagnosis, therapy, and mechanism of hemichorea associated with non-ketotic hyperglycemia (HC-NH) so as to enhance awareness avoid misdiagnosis or missed diagnosis disease. Methods: A case HC-NH was reported reviewed in terms features, treatment. Results: Hemichorea is a rare complication diabetes mellitus, which commonly seen elderly women poorly-controlled diabetes. The condition characterized by hyperglycemia, unilateral involuntary...

10.3389/fneur.2020.00096 article EN cc-by Frontiers in Neurology 2020-02-25

<b><i>Objectives:</i></b> This study aimed to investigate the roles of connective tissue growth factor (CTGF) and transforming factor-β<sub>1</sub> (TGF-β<sub>1</sub>) in atrial fibrosis patients with chronic fibrillation. <b><i>Methods:</i></b> Up 40 cases involving simple mitral valve replacement surgery were divided into 2 groups: fibrillation (cAF) group (n = 28) sinus rhythm 12). Echocardiography was used measure...

10.1159/000347126 article EN Cardiology 2013-01-01

Despite current recommendations for heart failure with preserved ejection fraction (HFpEF), few studies have demonstrated the ability of MRI to identify subtle functional differences between HFpEF essential hypertension (HFpEF-HTN) patients and (HTN).This study aimed detect evaluate in HTN using feature-tracking (FT) ascertain optimal strain cutoffs diagnosis HFpEF-HTN.Retrospective study.Three groups (84 HFpEF-HTN; 72 HTN; 70 healthy controls).1.5T, steady-state free precession (SSFP),...

10.1002/jmri.27313 article EN Journal of Magnetic Resonance Imaging 2020-09-07

Background Left ventricular ( LV ) involvement is common in arrhythmogenic right cardiomyopathy ARVC ). We aim to evaluate patients by cardiovascular magnetic resonance feature tracking. Methods and Results Sixty‐eight with 30 controls were prospectively enrolled. divided into 2 subgroups: the preserved ejection fraction (LVEF) group LVEF ≥55%, n=27) reduced <55%, n=41). Cardiovascular late gadolinium enhancement LGE tracking performed all subjects. global regional (basal, mid, apical)...

10.1161/jaha.119.012989 article EN cc-by-nc-nd Journal of the American Heart Association 2019-08-23

Abstract Objective To assess the association of preoperative lymphocyte‐to‐monocyte ratio (LMR) and overall survival (OS) in patients with oral cancer develop a dynamic nomogram for individualized prediction. Method The prognostic value LMR was evaluated large‐scale cohort 651 postoperative between January 2010 December 2017. Propensity score‐matched (PSM) analysis inverse probability treatment weighting (IPTW) were performed to further verify LMR. A then developed based on...

10.1111/odi.13629 article EN Oral Diseases 2020-09-03

Evidence about ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and oral cancer risk were limited. We aimed to evaluate the association of erythrocyte PUFAs with in a population from China.Erythrocyte 236 patients 300 controls determined by gas chromatography. Restricted cubic spline logistic regression used analyze between risk. The crude adjusted OR 95% CI was calculated. Stratification analysis performed explore potential interaction other traditional factors such as smoking...

10.1038/s41387-020-00140-1 article EN cc-by Nutrition and Diabetes 2020-09-28

The aim of the study was to elucidate relationship between systemic inflammation response index (SIRI) and prognosis postoperative oral squamous cell carcinoma (OSCC) patients.The prognostic value SIRI evaluated in a prospective cohort consisting 535 OSCC patients with surgical resection. Propensity score matching (PSM) inverse probability treatment weighting (IPTW) analyses were used further verify SIRI.Patients higher had significantly increased risk mortality compared those low (HR...

10.1002/hed.26375 article EN Head & Neck 2020-07-18

This study aimed to investigate the significance of prethrombotic state (PTS) and 4 plasma markers in predicting perisurgical adverse cardiac events patients with coronary heart disease (CHD) undergoing abdominal surgery. Perioperative effects were recorded 128 consecutive CHD elective Plasma d-dimer, P-selectin, von Willebrand factor (VWF), thrombus precursor protein measured before after Patients abnormal values one or more PTS identified as having PTS, data analyzed by univariate...

10.1177/1076029612470489 article EN Clinical and Applied Thrombosis/Hemostasis 2012-12-21

Abstract Background Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset who are predisposed to high risk recurrence or death. Previous evidence was limited by small sample sizes and lack validation. Methods We aimed identify early indicators develop a stratification model inform prognosis employing two large prospective cohorts. Prognostic factors for II tumors, including T stage,...

10.1186/s12916-022-02693-7 article EN cc-by BMC Medicine 2023-01-04

Background: Endothelial dysfunction and increased arterial stiffness gradually develop before the manifestation of catastrophic cardiovascular events. Therefore, detection assessment vascular function are required to address pre-existing pathological conditions. However, currently available diagnostic devices methods insufficient due variability among investigators time-consuming nature manual procedures. Methods: Recently, novel were developed for both endothelial in a single blood pressure...

10.1080/10641963.2018.1465072 article EN Clinical and Experimental Hypertension 2018-05-08

Insulin resistance (IR) is a complex pathological condition resulting from the dysregulation of cellular response to insulin hormone in insulin-dependent cells and recognized as pathogenic hallmark strong risk factor for metabolic syndrome. The present study aims elucidate molecular mechanism pathogenesis IR. Here, we used human umbilical vein endothelial (HUVECs) establish IR cell model induced by 1 × 10-6 mmol/L insulin. After 48 h, reactive oxygen species (ROS) glucose consumption were...

10.1080/15384101.2020.1870335 article EN Cell Cycle 2021-01-28

In the study, we aimed to explore and analyze potential function of SPOC Domain Containing 1 (SPOCD1) in esophageal squamous cell carcinoma (ESCC). We performed a comprehensive analysis gene expression SPOCD1 its corresponding clinicopathological features ESCC. particular, correlation between ESCC was evaluated using wide range tools databases, including TCGA, GTEx, GenePattern, CellMiner, GDSC, STRING datasets. Different bioinformatics analyses, differential analysis, mutation drug...

10.3389/fgene.2022.872026 article EN cc-by Frontiers in Genetics 2022-05-11

Abstract In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) interventricular (VV) delay optimizations after cardiac resynchronization therapy (CRT) with pacing (CRT-P) defibrillator (CRT-D) therapy. One hundred ninety-six subjects (50%) had dilated cardiomyopathy, 108 (27.6%) ischemic disease 112 (28.6%) hypertensive randomized into (198)...

10.1038/s41598-018-22525-0 article EN cc-by Scientific Reports 2018-03-05

Abstract Objective To investigate possible associations between disease‐specific survival (DSS) of oral cancer and single nucleotide polymorphisms (SNPs) in transforming growth factor beta receptor 1 ( TGFBR1 ). Methods Using iPLEX Sequenom MassARRAY platform, three SNPs gene were genotyped 356 newly diagnosed patients with histologically confirmed primary cancer. Demographic clinical information all cases obtained from face‐to‐face interviews electronic medical records, telephone carried...

10.1111/jop.12967 article EN Journal of Oral Pathology and Medicine 2019-10-25

to retrospectively investigate the efficacy and safety of application 28 mm cryoballoon for pulmonary vein electrical isolation (PVI) combined with top left atrial linear ablation vestibular expansion persistent fibrillation.From July 2016 December 2020, 413 patients diagnosed fibrillation were evaluated, including 230 (55.7%) in PVI group (PVI only) 183 (44.3%) PVIPLUS plus apex vestibule). The two groups analyzed.The AF/AT/AFL-free survival rates at 6, 12, 18, 24 30 months after procedure...

10.1016/j.hjc.2023.03.008 article EN cc-by-nc-nd Hellenic Journal of Cardiology 2023-04-04

To evaluate the prognostic performance of a novel nutritional risk score based on serum iron, hemoglobin, and body mass index (BMI) in oral cancer patients, to predict response chemotherapy patients with different status.X-tile analysis was performed determine optimal cutoff values BMI. A established by using HR Kaplan-Meier curve multivariable Cox proportional hazards models were used value overall survival (OS) cancer-specific (OCSS).Serum all inversely related prognosis cancer. The...

10.1111/odi.13733 article EN Oral Diseases 2020-11-25
Coming Soon ...