A5039847732- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Congenital Diaphragmatic Hernia Studies
- Neonatal and Maternal Infections
- Retinopathy of Prematurity Studies
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Preterm Birth and Chorioamnionitis
- Child and Adolescent Health
- Infant Nutrition and Health
- Mitochondrial Function and Pathology
- Atomic and Subatomic Physics Research
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Pulmonary Hypertension Research and Treatments
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Atherosclerosis and Cardiovascular Diseases
- Material Properties and Processing
- Surfactants and Colloidal Systems
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Neuroscience of respiration and sleep
Jagiellonian University
2013-2024
Boston Children's Hospital
2014
We assessed the long-term renal complications in a regional cohort of extremely low birth weight (ELBW) children born 2002-2004. The study group, comprising 78 as ELBW infants (88% available cohort), was evaluated with measurement serum cystatin C, urinary albumin excretion, ultrasound, and 24-h ambulatory blood pressure measurements. control group included 38 full-term selected from one general practice district. Study patients were at mean age 6.7 years, had median birthweight 890 g...
Programmed death-1 (PD-1) receptor system represents a part of recently reported immunoregulatory pathway. PD-1 is an immune checkpoint molecule, which plays important role in downregulating the proinflammatory activity. Until recently, expression was not established on cells preterm infants. The study objectives were to confirm receptors monocytes isolated from very low birth weight newborns (VLBW), and analyze their during first week life late-onset sepsis. Peripheral blood mononuclear 76...
BackgroundThe aim of the study was to analyse body composition preterm infants fed with either breast milk or formula compared a control group full-term newborns.MethodsFifty-three newborns were enrolled: 34 very low birth weight (VLBW) subdivided into formula-fed (n = 23; A) and milk-fed 11; B) group, 19 (group C). Their assessed by bioelectrical impedance analysis (BIA) at estimated time in VLBW during 1st week life group.ResultsThere no difference length between any three studied groups....
<b><i>Background:</i></b> Bronchopulmonary dysplasia (BPD) is a common cause of abrupted lung development after preterm birth. BPD may lead to increased rehospitalization, more severe and frequent respiratory infections, life-long reduced function. The gene regulation in lungs with complex, various genetic epigenetic factors involved. <b><i>Objectives:</i></b> aim this study was examine the regulatory relation between expression epigenome (DNA...
To expand the knowledge about consecutive expression of genes involved in immune system development preterm neonates and to verify if environment changes gene after birth we conducted a prospective study that included three cohorts: (A) extremely (gestational age (GA): 23–26 weeks;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>41</mml:mn></mml:math>), (B) very (GA: 27–29...
Neuroblastoma (NB), Hirschsprung disease (HSCR), Congenital Central Hypoventilation Syndrome (CCHS), clinically referred as the NB-HSCR-CCHS cluster, are genetic disorders linked to mutations in PHOX2B gene on chromosome 4p12.The specific aim of this project is define genomic basis for clinical manifestations cluster.A one day old male patient presented Jagiellonian University Medical College (JUMC), American Children Hospital, neonatal Intensive Care Unit (ICU) due abdominal distention,...
In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), add new insights into a better understanding of the pathogenesis disease. Cord peripheral blood neonates (≤ 30 weeks gestational age) was drawn at birth 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided BPD(+) BPD(−) groups, according development BPD. Children BPD characterized by decreased afamin, gelsolin...
Premature infants represent one of the groups with increased risk for metabolic syndrome. Our study is first to evaluate irisin and visfatin levels, associated syndrome, both in blood preterm full-term infants, as well breastmilk their mothers. A total 72 newborns was enrolled study, including 53 very low birth weight a control group 19 term infants. The levels were determined by commercial enzyme-linked immunoabsorbent assay baby serum maternal milk twice, during 1st week life then 4 weeks...
Purpose: Retinopathy of prematurity (ROP) is a vision-threatening complication premature birth, in which the etiology still remains unclear. Importantly, molecular processes that govern these effects can be investigated perturbed plasma proteome composition. Thus, proteomics may add new insights into better understanding pathogenesis this disease. Methods: The cord and peripheral blood neonates (≤30 weeks gestational age) was drawn at birth 36th postmenstrual week (PMA), respectively. Blood...
Abstract Purpose Lung ultrasound (LUS) at the point‐of‐care is a new method that increasingly used in neonatology. The aim of this study was to determine utility addition LUS prior interhospital transport neonates with respiratory failure. Methods performed on 50 newborns failure tertiary neonatal intensive care unit. We analyzed performance for diagnosing cause failure, concordance between LUS, chest X‐ray (CXR) and final clinical diagnosis, impact decision making before transport. Results...
Abstract Background We aimed to identify global blood and retinal gene expression patterns in murine oxygen-induced retinopathy (OIR), a common model of prematurity, which may allow better understanding the pathogenesis this severe ocular prematurity complication identification potential biomarkers. Methods A total 120 C57BL/6J mice were randomly divided into an OIR group, 7-day-old pups maintained 75% oxygen for 5 days, or control group. RNA was extracted from whole-blood mononuclear cells...
<b><i>Background:</i></b> The long-term impact of prematurity on cardiac structure and function has not yet been fully discovered. <b><i>Objectives:</i></b> To assess complications in the regional cohort extremely low birth weight (ELBW) children born 2002-2004. <b><i>Material Methods:</i></b> Eighty-one as ELBW infants (91% available cohort) with a median 890 g (25-75th percentile: 760-950) were evaluated at mean age...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Mazurek M, Mól N, Zasada W, Pyznar O, Kwinta P. Dietary supplements use among children from south-eastern Poland. Pediatria Polska - Polish Journal of Paediatrics. 2022;97(1):13-19. doi:10.5114/polp.2022.114951. APA Mazurek, M., Mól, N., Zasada, W., Pyznar, O., & Kwinta, (2022). Paediatrics, 97(1), 13-19. https://doi.org/10.5114/polp.2022.114951 Chicago Małgorzata, Nina Magdalena Wojciech Olga and Przemko...
Objective: To examine the gene expression regarding pulmonary vascular disease in experimental bronchopulmonary dysplasia young mice. Premature delivery puts babies at risk of severe complications. Bronchopulmonary (BPD) is a common complication premature birth leading to lifelong affection function. BPD recognized as arrested alveolar development. The process not fully described and no complete cure or prevention known. focus interest search for treatment has traditionally been airspace...
Abstract Objective Magnetic resonance spectroscopy ( 1 H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury. Study design 46 very infants (VP) were evaluated by magnetic imaging and H-MRS at term-equivalent age. Brain injury was assessed according to Kidokoro scale. Moreover, 17 term-born with hypoxic-ischemic encephalopathy (HIE) scanned. The profile central nervous system obtained from bilateral thalamus. Result...
Introduction This study aimed to assess the association between urinary lactate-to-creatinine ratio (ULCR) and brain spectroscopy (1H-MRS) findings in very-low-gestational-age (VLGA) infants with without preterm injury. Methods Urine samples were collected from 54 VLGA during first week of life, after one month at term-equivalent age (TEA). Urinary lactate was measured via highly selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) a quantitative Organic Acid Analysis Kit...
Irisin is a newly discovered myokine with antiobesity properties. The delivery of irisin the breast milk or formula an emerging concept that present at human influences postnatal energy balance and developmental parameters. aim study was to evaluate concentration in mothers term preterm babies infant formulas.A total 49 lactating were enrolled study: 31 very low birth weight infants 18 infants. Milk samples collected twice: during first week after 4 weeks delivery. determined using ELISA...
BACKGROUND: Irisin is a newly discovered myokine with anti-obesity properties. The delivery of irisin the breast milk or formula an emerging concept that present at human influences postnatal energy balance and developmental parameters. aim study was to evaluate concentration in mothers term preterm babies infant formulas.METHODS: A total 49 lactating were enrolled study: 31 very low birth weight infants 18 infants. Milk samples collected twice: during first week after 4 weeks delivery....