Joanna Clasen
A5072827349- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Diet and metabolism studies
- Digestive system and related health
- Diet, Metabolism, and Disease
- Celiac Disease Research and Management
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Risks and Factors
- Thyroid Disorders and Treatments
- Fluoride Effects and Removal
- Eosinophilic Esophagitis
- Genetic and phenotypic traits in livestock
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Adrenal Hormones and Disorders
- Diabetes Management and Education
University of South Florida
2016-2024
Imperial College London
2020-2023
St Mary's Hospital
2020-2021
Objective The capacity to precisely predict progression type 1 diabetes (T1D) in young children over a short time span is an unmet need. We sought develop risk algorithm with high-risk human leukocyte antigen (HLA) genes followed Environmental Determinants of Diabetes the Young (TEDDY) study. Methods Logistic regression and 4-fold cross-validation examined 38 candidate predictors from clinical, immunologic, metabolic, genetic data. TEDDY subjects at least one persistent, confirmed...
A total of 15 SNPs within complement genes and present on the ImmunoChip were analyzed in The Environmental Determinants Diabetes Young (TEDDY) study. 5474 subjects followed from three months age until islet autoimmunity (IA: n = 413) subsequent onset type 1 diabetes (n 115) for a median 73 (IQR 54-91). Three ITGAM nominally associated (p < 0.05) with IA: rs1143678 [Hazard ratio; HR 0.80; 95% CI 0.66-0.98; p 0.032], rs1143683 [HR 0.65-0.98; 0.030] rs4597342 1.16; 1.01-1.32; 0.041]. When was...
PURPOSE: To evaluate timing and outcomes of BRCA testing definitive surgical treatment among patients with newly diagnosed breast cancer. METHODS: Patient-reported (n = 1,381) deidentified health-plan 2,369) data were analyzed from a consecutive national series 3,750 women whose healthcare providers ordered between March 2014 June 2015, within 1 year following cancer diagnosis. RESULTS: Among 1,209 respondents, 54.4% received the genetic test results presurgery, 23.2% tested presurgery but...
To examine adherence to the oral glucose tolerance test (OGTT) in multiple islet autoantibody children stage 1 of developing type diabetes (T1D).
Vitamin D is important for immunomodulation and may play a role in autoimmune diseases. Studies have reported high prevalence of vitamin deficiency rheumatoid arthritis (RA) patients, status, assessed by circulating 25-hydroxyvitamin [25(OH)D] concentration, inversely associated with RA disease activity. However, it unclear whether increases the risk later developing RA. We conducted systematic review meta-analysis pre-diagnostic 25(OH)D concentrations RA.Medline Embase databases were...
Abstract Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption sweetened beverages has been linked to several chronic diseases, including some types cancer. It uncertain whether soft drink juice associated with RCC. We investigated the associations RCC incidence mortality European Prospective Investigation into Cancer Nutrition (EPIC). Methods: A total 389,220 EPIC participants median age 52...
Abstract Context Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define preclinical autoimmune disease (AITD), which can progress either clinical hypothyroidism or hyperthyroidism. Objective We determined the age at seroconversion in children genetically risk for type 1 diabetes. Methods TPOAb TgAb seropositivity were 5066 healthy with human leukocyte antigen (HLA) DR3- DR4-containing haplogenotypes from The Environmental Determinants of Diabetes Young (TEDDY) study....
(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs BC risk, adopting data from European Prospective Investigation into Cancer Nutrition (EPIC) cohort; (3) Results: 318,686 pre- postmenopausal women were followed enrolment 1992–2000 December 2013–December 2015. Dietary MGD estimated at baseline...
Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, would need focus on people at high risk clinically meaningful so as limit overdiagnosis and screen-detected false positives.
Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration pyridoxal 5′-phosphate (PLP) is a commonly used measure vitamin status. Ratios substrates indicating PLP coenzymatic function metabolism may be useful complementary measures further explore the role in health. We explored sensitivity 5 outcomes, namely concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), 3´-hydroxykynurenine ratio...
Abstract Background Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There currently little evidence on the roles of reproductive risk in RCC aetiology. Materials & Methods We investigated associations age at menarche menopause, pregnancy‐related factors, hysterectomy ovariectomy exogenous hormone use 298,042 women European Prospective Investigation into Cancer Nutrition (EPIC)...
Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, an etiological role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor the transsulfuration pathway. We sought to holistically investigate pathway RCC risk. conducted nested case-control study (455 cases and 455 matched controls) within European Prospective Investigation into Cancer Nutrition (EPIC) study. Plasma samples from baseline visit were analyzed for metabolites...
Objective: We studied if vitamin D intake was associated with risk of IA or progression to T1D and whether single nucleotide polymorphisms (SNP) in metabolism genes modify the effect on risk. Methods: followed 7,520 high children from birth until development IA, defined as persistent GAD65 (GADA), insulin (IAA) and/or IA-2 autoantibodies, T1D. Vitamin foods supplements estimated 3 day food records collected quarterly first year then semi-annually age 10. analyzed per energy time-dependent...
Islet autoantibodies (IA) that precede type 1 diabetes, tissue transglutaminase (tTGA) preceding celiac disease, and thyroid peroxidase (TPOA) or thyroglobulin (ThGA) autoimmune disease may coincide. We aim to describe the order of first appearance IA, tTGA, autoimmunity in children, as well role risk subsequent development IA tTGA. Children (n = 5437) with a genetically determined high for from USA, Finland, Germany, Sweden were followed birth age 14 diabetes diagnosis. Cox regression was...
Abstract Background An “obesity paradox” has been reported in kidney cancer, whereby obesity is a risk factor, yet appears to be associated with better survival. To evaluate this paradox, we investigated the association between pre-diagnostic adiposity and renal cell carcinoma (RCC) incidence mortality. Methods Using data from 363,521 men women European Prospective Investigation into Cancer Nutrition (EPIC), Cox regression models yielded confounder-adjusted hazard ratios (HRs) 95% confidence...
Abstract Background Several biological pathways implicated in cancer risk rely on vitamin B6, which can be measured its active form pyridoxal 5’-phosphate (PLP). Functional markers of B6 enzymatic activity have been proposed, including the homocysteine:cysteine ratio (Hcy:Cys, a marker transsulfuration), 3-hydroxykynurenine (HKr, tryptophan catabolism), and 4-pyridoxic acid (PAr, catabolism). We investigated extent to these are associated with intake. Methods Data from 4,750 participants...