A5000926554- Cardiovascular Effects of Exercise
- Sports injuries and prevention
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Cardiac Imaging and Diagnostics
- Neural dynamics and brain function
- Estrogen and related hormone effects
- Food composition and properties
- Health, Environment, Cognitive Aging
- Intimate Partner and Family Violence
- Medicinal Plants and Bioactive Compounds
- Diabetic Foot Ulcer Assessment and Management
Johns Hopkins University
2017-2024
University of Padua
2019-2024
Johns Hopkins Medicine
2017-2024
National Institutes of Health
2021-2023
National Institute on Aging
2021-2023
Institute on Aging
2021
Tongji University
2019
China-Japan Friendship Hospital
2019
Qilu Hospital of Shandong University
2019
Scuola Superiore Sant'Anna
2015-2019
Myocyte death occurs in many inherited and acquired cardiomyopathies, including arrhythmogenic cardiomyopathy (ACM), a genetic heart disease plagued by the prevalence of sudden cardiac death. Individuals with ACM harboring pathogenic desmosomal variants, such as desmoglein-2 (DSG2), often show myocyte necrosis progression to exercise-associated failure. Here, we showed that homozygous Dsg2 mutant mice (Dsg2 mut/mut), model ACM, die prematurely during swimming display myocardial dysfunction...
Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic stimulation enhances local BDNF expression. It is unclear if this occurs in a pathophysiological relevant manner the heart, especially receptor-desensitized postischemic myocardium. Nor it fully understood whether how TrkB agonists counter chronic left ventricle (LV) decompensation, significant unmet clinical milestone. We...
Obesity and psychosocial stress (PS) co-exist in individuals of Western society. Nevertheless, how PS impacts cardiac hippocampal phenotype obese subjects is still unknown. Nor it clear whether changes local brain-derived neurotrophic factor (BDNF) account, at least part, for myocardial behavioral abnormalities experiencing PS.In adult male WT mice, obesity was induced via a high-fat diet (HFD). The resident-intruder paradigm superimposed to trigger PS. In vivo left ventricular (LV)...
Abnormalities in cardiac energy metabolism occur heart failure (HF) and contribute to contractile dysfunction, but their role, if any, HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle reserve reaction which rapidly provides ATP at myofibrils regenerates mitochondrial ADP, down-regulated experimental human HF. We tested hypotheses that HF related impaired rescuing attenuates maladaptive hypertrophy
Long COVID-19 patients show systemic inflammation and persistent symptoms such as fatigue malaise, profoundly affecting their quality of life. Since improving oxygenation can oppose at multiple tissue levels, we hypothesized that hyperbaric oxygen therapy (HBOT) could arrest progression thus relieve COVID-19. We evaluated oxy-inflammation biomarkers in long subjects treated with HBOT monitored non-invasive methods. Five (two athletes three other comorbidities) were assigned to receive HBOT:...
Physiological stressors, such as exercise, can precipitate sudden cardiac death or heart failure progression in patients with arrhythmogenic cardiomyopathy (ACM). Yet, whether and to what extent a highly prevalent more elusive environmental factor, psychosocial stress (PSS), also increase ACM disease is unexplored. Here, we first quantified perceived levels found these correlated the of arrhythmias dysfunction. To determine observed correlation due causation, inflicted PSS-via...
Divers can experience cognitive impairment due to inert gas narcosis (IGN) at depth. Brain-derived neurotrophic factor (BDNF) rules neuronal connectivity/metabolism maintain function and protect tissues against oxidative stress (OxS). Dopamine glutamate enhance BDNF bioavailability. Thus, we hypothesized that lower circulating levels (via lessened dopamine and/or release) underpin IGN in divers, while testing if loss is associated with increased OxS.To mimic IGN, administered a deep test via...
Intimate partner violence (IPV) is a significant public health concern whose neurological/behavioral sequelae remain to be mechanistically explained. Using mouse model recapitulating an IPV scenario, we evaluated the female brain neuroendocrine alterations produced by reiterated male-to-female violent interaction (RMFVI). RMFVI prompted anxiety-like behavior in mice hippocampus displayed marked neuronal loss and hampered neurogenesis, namely reduced BrdU-DCX-positive nuclei diminished...
Summary We investigated changes of slow‐wave activity and sleep slow oscillations in the night following procedural learning boosted by reinforcement learning, how these correlate with behavioural output. In Task session, participants had to reach a visual target adapting cursor's movements compensate an angular deviation introduced experimentally, while Control session no was applied. The task repeated at 13:00 hours, 17:00 hours 23:00 before sleep, 08:00 after sleep. angle set 15° (13:00...
In the normal heart, frequently used anesthetics such as isoflurane and propofol can reduce inotropy. However, impact of these agents on failing myocardium is unclear. Here, we examined whether how influence cardiac contractility in intact muscles from rats treated with monocrotaline to induce heart failure. We measured force intracellular Ca<sup>2+</sup> ([Ca<sup>2</sup><sup>+</sup>]<sub>i</sub>) trabeculae right ventricles absence or presence isoflurane. At low moderate concentrations,...
General anesthesia may be a risk factor for post-operative cognitive impairment, which could counteracted by neuroprotective compounds. The aims of this study were to determine functions impaired general and test blueberry juice as agent against neuropsychological dysfunctions induced anesthesia.Twenty-six patients undergoing elective major surgery randomized into two groups, receiving either 500 mL/day within 14 preoperative days (G1) or control group (G0). Neuropsychological tests...
High‐fat diet (HFD)‐induced obesity causes insulin resistance and increases vulnerability to chronic psychosocial stress‐induced dysfunctions, including anxiety mood disorders, cognitive decline myocardial ischemia. The inhibition of class I histone deacetylases leads metabolic homeostasis dietary barley (1.3) beta‐D‐glucan (β‐D‐glucan), a water‐soluble polysaccharide, levels H4 acetylation. We tested whether the long‐term intake β‐D‐glucan prevents glucose intolerance, affective disorders...
Medicine and Surgery, University of Pisa, via Savi 10, 56126, Italy Sleep spindles are electroencephalographic oscillations peculiar non-REM sleep, related to neuronal mechanisms underlying sleep restoration learning consolidation. Based on their very singular morphology, can be visually recognized detected, even though this approach lead significant mis-detections. For reason, many efforts have been put in developing a reliable algorithm for spindle automatic detection, number methods,...
<b>Abstract ID 24433</b> <b>Poster Board 157</b> <b>Rationale:</b> Lack of brain-derived neurotrophic factor (BDNF) and/or inadequate expression/activity its associated tropomyosin kinase receptor B (TrkB) account for brain and cardiac disorder. While β-adrenergic (βAR) is responsible the local expression BDNF in neurons, whether a similar interaction observed pathophysiologically relevant cardiovascular system unknown, especially post-ischemic myocardium with adrenergic desensitization....
Abstract Women are the main target of intimate partner violence (IPV), which is escalating worldwide. Mechanisms subtending IPV-related disorders, such as anxiety, depression and PTSD, remain unclear. We employed a mouse model molded on an IPV scenario (male vs. female prolonged violent interaction) to unearth neuroendocrine alterations triggered by aggressive male murine brain. Experimental (EIPV) prompted marked anxiety-like behavior in young mice, coincident with high circulating/cerebral...
Introduction: Prolyl-tRNA synthetase (PRS), a member of aminoacyl tRNA synthetases (ARS), is an enzyme that conjugates amino acid proline to its cognate generate prolyl-tRNA be used in protein synthesis.Since ARS are essential for synthesis and viability, dysregulation has been proposed many human diseases.Cardiac fibrosis characterized by excess production deposition ECM proteins activated fibroblast.Although main component collagen proteins, the exact mechanism involvement PRS cardiac not...