A5087613427- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Occupational and environmental lung diseases
- Thermal Regulation in Medicine
- Advanced MRI Techniques and Applications
- Palliative Care and End-of-Life Issues
- Traumatic Ocular and Foreign Body Injuries
- Health Promotion and Cardiovascular Prevention
- Atomic and Subatomic Physics Research
- Clinical Laboratory Practices and Quality Control
- Electroconvulsive Therapy Studies
- Inflammatory Myopathies and Dermatomyositis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Innovations in Medical Education
- Inhalation and Respiratory Drug Delivery
- Infectious Aortic and Vascular Conditions
- Sleep and Work-Related Fatigue
- Digital Imaging for Blood Diseases
- Radiology practices and education
University of Toronto
2013-2024
Sunnybrook Health Science Centre
2021-2024
Health Sciences Centre
2021-2024
London Health Sciences Centre
2022
University Health Network
2000-2022
Institute for Clinical Evaluative Sciences
2020-2021
Hospital for Sick Children
2021
SickKids Foundation
2021
Western University
2019
Patients with chronic hepatitis C infection often experience fatigue. In many clinical situations, an association between fatigue and altered serum cytokine levels has been found. Altered in patients have not shown a correlation the degree of transaminase elevation or pathological change on liver biopsy. The aim our study was to examine whether there abnormal compensated C. referred tertiary care hepatology clinic who were antibody positive had elevated alanine aminotransferase (ALT)...
Immunohistochemistry (IHC) assessment of tissue is a central component the modern pathology workflow, but quantification challenged by subjective estimates pathologists or manual steps in semi-automated digital tools. This study integrates various computer vision tools to develop fully automated workflow for quantifying Ki-67, standard IHC test used assess cell proliferation on whole slide images (WSIs).We create an nuclear segmentation strategy deploying Mask R-CNN classifier recognise and...
Two trials of clinically approved human papillomavirus (HPV) vaccines, Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE I/II) and the Papilloma Trial Against Cancer in Young Adults (PATRICIA), reported a 22% difference vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 2 or worse HPV-naïve subcohorts; however, serological testing methods HPV DNA criteria used define HPV-unexposed women differed between studies. We applied previously described...
In the early 1930s, American neurologist and psychiatrist William Bleckwenn used sodium amytal to render catatonic patients responsive, so that he could engage in talk therapy. found a new, ‘off-label’ use for this anaesthetic anxiolytic medication psychiatry and, doing so, allowed important discoveries diagnosis treatment of catatonia. Pharmacological textbooks reveal ‘label’, while Index-Catalogue Library Surgeon-General’s Office reveals explorations ‘off label’ barbiturates. The...
We conducted a study using an ex-vivo porcine model to evaluate whether thulium fiber laser (TFL) induces ocular injury in the context of inadvertent exposure beam.A 365 μm TFL was positioned at set distance (0 cm, 5 8 and 10 cm) from freshly harvested (<12 hours) eyeball activated for one second select settings lithotripsy (0.2 J 50 Hz, 0.5 20 1 Hz) soft tissue ablation (2 Hz). The experiment repeated with safety goggles prescription eyeglasses. Thermal assessed by histopathological...
The contributions of arts and humanities to medical education are known in the community, but schools' offerings vary. Companion Curriculum (CC) is a student-curated set optional content for students at University Toronto. This study evaluates integration CC identify key enabling conditions engagement.A mixed-methods evaluation gauged usage perceptions among using an online survey focus groups. Narrative data underwent thematic analysis, supported by summary statistics quantitative data.Half...
The threat of pandemic is looming in the public consciousness. Outbreaks infectious diseases are tracked order to respond and prevent epidemics. Historically, both passive active methods have been used. A promising development use social media, such as Twitter or Google, track predict outbreaks. Active monitoring consists reporting collection health information, while involves studying data from clinicians infer if an outbreak has occurred. Social media provides a wealth information analyze...
Patients with restrictive cardiomyopathy due to Fabry disease are often deemed ineligible for left ventricular assist device (LVAD) support the risk of suction events a small LV cavity. We describe first case series LVAD disease. therapy can improve survival, quality life, and provide clinical stability start enzyme replacement therapy. Precautions at time surgery include rapid treatment fever avoid crises, involvement multidisciplinary team, early initiation rehabilitation. both bridging destination
This study aimed to characterise priority or 'rush' surgical pathology requests and identify potentially targetable factors. We performed a retrospective descriptive analysis of rush at our institution from 2016 2019 conducted survey asking pathologists about their perspectives on cases. There were 3677 cases, with case characteristics generally stable over the period. Two categories identified based hospital status; outpatient more frequently provided specific date for diagnosis, while...