A5003910566- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Cancer, Hypoxia, and Metabolism
- Cardiac Structural Anomalies and Repair
- Antimicrobial Resistance in Staphylococcus
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Anomalies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease and Transplantation
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Cardiac Ischemia and Reperfusion
- Galectins and Cancer Biology
University of Tokyo Hospital
2017-2024
The University of Tokyo
2012-2024
Japanese Red Cross Medical Center
2010
Abstract In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry pyruvate into tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen availability during its migration process inflammatory areas. Here we show that HIF-1α-PDK1-mediated metabolic changes occur mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting mode glycolytic reprogramming....
Abstract The fibrogenic response in tissue-resident fibroblasts is determined by the balance between activation and repression signals from tissue microenvironment. While molecular pathways which transforming growth factor-1 (TGF-β1) activates pro-fibrogenic mechanisms have been extensively studied are recognized critical during fibrosis development, factors regulating TGF-β1 signaling poorly understood. Here we show that macrophage hypoxia suppresses excessive a heart via oncostatin-m (OSM)...
Vascular endothelial growth factor‐A (VEGF‐A) is one of the major angiogenic factors, and its actions are primarily mediated through two membrane receptors, VEGFR‐1 VEGFR‐2. A soluble form (sVEGFR‐1) sequesters free VEGF‐A, acts as a potent anti‐angiogenic factor. While sVEGFR‐1 synthesized splice variant VEGF‐R1 gene, interactions between VEGF‐A remain largely unknown. Here, we show that upregulates sVEGF‐R1 expression in human vascular cells but leaves full‐length unchanged, this induction...
Lung transplantation (LT) is the only option for patients with pulmonary arterial hypertension (PAH) refractory to maximal medical therapy. However, some referred LT could survive without LT, and its determinants remain unclear. This study aimed elucidate prognostic factors of severe PAH at referral time. We retrospectively analyzed 34 evaluation. The primary outcome was a composite death or LT. Over median follow-up period 2.56 years, eight received died. Compared LT-free survival group,...
Whether comprehensive risk assessment predicts post-referral outcome in patients with pulmonary arterial hypertension (PAH) referred for lung transplantation (LT) Japan is unknown.
Abstract Pancreatic cancer is one of the malignant diseases with worst prognosis. Resistance to chemotherapy a major difficulty in treating disease. We analyzed plasma samples from genetically engineered mouse model pancreatic and found soluble vascular cell adhesion molecule-1 (sVCAM-1) increases response gemcitabine treatment. VCAM-1 was expressed secreted by murine human cells. Subcutaneous allograft tumors overexpression or knock-down VCAM-1, as well VCAM-1-blocking treatment spontaneous...
Acute vasoreactivity test with inhaled nitric oxide (NO) is performed during diagnostic right heart catheterization (RHC) to identify patients pulmonary arterial hypertension (PAH) who respond calcium channel blockers. Our purpose was investigate the prognostic importance of follow-up after treatment.We retrospectively analyzed 36 PAH (mean age, 47 years; 61 % treatment-naïve), underwent and RHC tests at our center. The primary outcome all-cause mortality.The median time between baseline 9.7...
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. integral function of mitochondrial respiration critically important the cope hemodynamic overload. involvement, however, activity or reactive oxygen species (ROS) pathogenesis ventricular-overload-induced has not been fully elucidated. We...
Progressive systemic right ventricle (sRV) dysfunction is a significant challenge in adult congenital heart disease. Current guidelines do not specify effective failure medications for patients with sRV; however, previous studies have relied on semiquantitative assessments. The advancement of cardiac magnetic resonance (CMR) imaging as the gold-standard modality offers quantitatively accurate assessments even complex anomalies. Therefore, we aimed to investigate prognostic factors associated...
Liver fibrosis caused by congestive hepatopathy has emerged as an important complication after Fontan procedure. We evaluated the utility of hepatic vein (HV) waveform using Doppler ultrasound for identification liver in patients.We investigated HV waveforms 41 patients and assessed correlations with clinical parameters, markers, hemodynamic data.Based on our preliminary analysis 64 adult chronic disease who underwent biopsy, we classified into five types reference to degree flattening (from...
Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little known about the myocardial involvement this disorder. An 82-year-old man with OI developed heart failure was admitted to our hospital. Echocardiogram revealed severe mitral without left ventricular (LV) dilatation, but LV wall thickening. Histological analysis exhibited interstitial fibrosis of myocardium addition myxoid changes leaflet. These findings suggest that patients may...
The subjects of 75 consecutive autopsies were examined for evidence chronic bronchitis. In multiple bronchial sections, estimates made the gland/wall ratio, intramural vascularization, scar, and round cell infiltration. Abnormalities in these parameters found more frequently patients who had cough, an increased ratio was often those sputum as well. diameter lumen to external small noncartilagenous bronchi did not correlate with clinical ability predict degree bronchitis from expiratory flow...
A 49-year-old man presenting with ST-elevated myocardial infarction was brought to our emergency department AL amyloidosis. Baseline coronary angiography showed no significant stenosis of the epicardial arteries, however, artery in response acetylcholine and flow reserve papaverine were abnormal, which suggested impairment vascular endothelial function. Myocardial biopsy revealed amyloid deposition exclusively intramural arteries. Early amyloidosis without involvement can produce acute...
The Japanese Network of Cardiovascular Departments for Adult Congenital Heart Disease (JNCVD-ACHD) was founded in 2011 the lifelong care adult patients with congenital heart disease (ACHD patients). This network maintains first ACHD registry.From to 2019, JNCVD-ACHD registered 54 institutions providing specialized 32 47 prefectures Japan. registry collected data on profile 24,048 from 50 and patient characteristics 9743 24 institutions. most common ACHDs were atrial septal defect (20.5 %),...
Left ventricular outflow tract obstruction (LVOTO) is commonly observed in patients with hypertrophic cardiomyopathy (HCM) or left hypertrophy (LVH). While some develop LVOTO at rest, it can also be provoked by physical exertion, and hence termed latent (L-LVOTO). Recent reports demonstrated that L-LVOTO develops not only LVH patients, but without (non-LVH). However, the prevalence clinical prognosis of non-LVH are yet elucidated. In this study, we retrospectively investigated...
It is widely known that β-blockers exert beneficial effects on non-ischemic and ischemic systolic heart failure (sHF) in nonstructural hearts. However, whether similar sHF associated with congenital disease (CHD), particularly an anatomical right ventricle, remains under debate.Here we report the case of adult man repaired tetralogy Fallot suffering from biventricular failure. Treatment carvedilol directly improved function left ventricles. This strongly suggests there potential for to a...
<h3>To the Editor.</h3> —With recent development of chromosome-banding techniques, several patients with congenital glaucoma due to a chromosomal abnormality have been described.<sup>1,2</sup>Though primary (PCG) has considered be an autosomal-recessive trait, clinical examinations demonstrated that such had characteristics PCG. We recently encountered boy both PCG and chromosome abnormality. <h3>Report Case.</h3> —The patient, born at 42 weeks' gestation weighing 3500 g, was third child...
Candida prosthetic endocarditis (CPE) is an uncommon and fatal complication in adults with congenital heart disease. The current guidelines for the management of fungal recommend a combination surgical medical therapy. However, it still remains uncertain when CPE patients should be performed. Therefore, prognosis very poor. Here we report case 31-year-old woman who had undergone repair tetralogy Fallot during childhood pulmonary valve replacement at age 21 years. She underwent re-pulmonary...
Individuals transitioning into adulthood require age-appropriate medical care and delegation of decision-making authority from their parents to the patients themselves. Although there have been multiple observational interventional studies on transitional for with congenital heart disease (CHD) in cardiovascular field, specific childhood-onset cardiomyopathy (CM) remains unaddressed.