A5018493677- Cardiovascular Function and Risk Factors
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Glioma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Nausea and vomiting management
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Heart Rate Variability and Autonomic Control
- Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Gastric Cancer Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cancer Treatment and Pharmacology
- Acute Myocardial Infarction Research
- Ovarian cancer diagnosis and treatment
- Cardiovascular Disease and Adiposity
- Coronary Artery Anomalies
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
Necmettin Erbakan University
2020-2025
Namık Kemal University
2025
Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi
2022-2023
Ege University
2022
Bridge University
2022
Afyon Kocatepe University
2022
University Research Co (United States)
2022
Konya Technical University
2021
Amsterdam University Medical Centers
2021
Vrije Universiteit Amsterdam
2021
The cysteine-rich epidermal growth factor ligand domain 2 protein (CRELD2) is associated with pathways that regulate epithelial-to-mesenchymal transition, a critical process driving cancer metastasis. This study aimed to determine the prognostic value of CRELD2 status on survival outcomes in triple-negative breast (TNBC). Seventy patients were included study. Thirty-four metastatic, and 36 non-metastatic. expression tumor tissue was determined by immunohistochemical (IHC) staining. divided...
aDepartment of Cardiology, Faculty Medicine, Tekirdag Namik Kemal University, bDepartment Cardiovascular Surgery, University Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey Received 3 December 2024 Accepted 5 2024. Correspondence to Cihan Aydin, MD, Department Tekirdag, Turkey, E-mail: [email protected]
Morphological, physiological and molecular changes were investigated in vitro salt-stressed barley (Hordeum vulgare L. cv. Tokak). Mature embryos cultured Murashige Skoog medium containing 0 (control), 50 100 mM NaCl for 20 days. Both concentrations inhibited shoot growth, decreased fresh weight protein content, increased SOD (EC 1.15.1.1) activity a dose-dependent manner. The lower concentration root growth. Salinity caused nucleotide variations roots, but did not affect DNAs. higher...
Purpose Postoperative LV dysfunction is associated with poor prognosis and increased mortality in patient mitral regurgitation undergoing surgery. With this study, we aimed to investigate the predictive value of classic speckle tracking echocardiographic ( STE ) deformational parameters for estimating postoperative dysfunction. Methods Fifty‐nine asymptomatic patients severe MR due valve prolapse, who had sinus rhythm ejection fraction EF ≥50%, were included. Patients underwent comprehensive...
It is red cell distribution width (RDW) that has been reported to show an inflammatory response which studied recently. The aim of this study investigate whether the pre-treatment RDW in patients using first-line vascular endothelial growth factor tyrosine kinase inhibitor (VEGFR TKI) with diagnosis metastatic renal carcinoma (mRCC) predicts treatment and a prognostic or not.About 92 diagnosed mRCC who were being treated sunitinib pazopanib first line between January 2015 June 2021 included...
The addition of aflibercept to the fluorouracil and irinotecan (FOLFIRI) regimen significantly improved clinical outcomes in patients with metastatic colorectal cancer (CRC) previously treated oxaliplatin. We aimed investigate efficacy safety second-line FOLFIRI combination CRC real-life experience.
Trastuzumab emtansine (TDM-1) is an antibody-drug conjugate effective in human epidermal growth factor receptor-2 - expressing advanced breast cancer. Pulmonary complications of TDM-1 are rarely reported. TDM-1-associated interstitial lung disease referred to as pneumonitis.A 47-year-old female patient who underwent modified radical mastectomy and axillary lymph node dissection operations due a palpable mass the right region. The had received multiple chemotherapy was last receiving...
Background: It is well known that patients with ST ‐elevation myocardial infarction ( STEMI ) show both systolic and diastolic left ventricular dysfunction. The aim of this study was to assess post–myocardial dysfunction using atrial ejection force LAEF in treated primary percutaneous coronary intervention PCI ). Methods Results: We enrolled 58 presenting who were 23 healthy subjects as a control group. A detailed transthoracic echocardiogram, including mitral flow velocities, tissue D...
Introduction Sweet Syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory disease characterized by the sudden emergence of painful, edematous, and erythematous papules, plaques, or nodules on skin, which usually fully responsive to systemic corticosteroids. Skin lesions are often accompanied fever leukocytosis. Here we present case Syndrome caused pemetrexed in metastatic lung adenocarcinoma. Case report A 52-year-old patient with adenocarcinoma received...
Introduction We compared the efficacy of first-generation granisetron and second-generation palonosetron in triplet anti-emetic prophylaxis patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based high emetogenic chemotherapy (HEC). Methods This prospective, multicenter, non-randomized, observational study was conducted between June 2018 December 2021. Patients diagnosed NSCLC who received prophylactic treatment aprepitant dexamethasone plus or before first cycle were...
There is growing evidence regarding the numerous adverse effects of synthetic cannabinoids (SCBs) on cardiovascular system; however, no studies have shown opioids using strain echocardiography. This study examines cardiac structure and function echocardiographic imaging in heroin cannabinoid users.This double-blind included patients who were admitted or referred to a rehabilitation center for (n=31) users (n=30). Heroin compared with healthy volunteers (n=32) two-dimensional (2D)...
Aim: Nimodipine is used to prevent cerebrovascular-originated ischemic neurological deficits, yet its effects on nucleus pulposus (NP) cells or annulus fibrosus (AF) weren’t studied. This study aimed examine nimodipine’s vitality and proliferation of chondroadherin (CHAD), type II collagen (COL2A1), hypoxia-inducible factor 1 alpha (HIF 1α) gene expression in human primary NP/AF cells. Material Methods: cell cultures obtained from 6 patients who underwent microdiscectomy were treated with...
The aim of this study was to evaluate the presence small bowel wall edema (SBWE) on computed tomography (CT) images in patients with metastatic renal cell carcinoma (mRCC) treated sunitinib and investigate relationship between SBWE survival.We retrospectively evaluated CT 27 mRCC who received at least one cycle sunitinib. Then, we analyzed progression-free survival (PFS) overall (OS).All had scan. median value thickness 2.5 mm. ≤2.5 mm 13 (group A) >2.5 14 B). OS significantly higher group B...
Background: We aimed to investigate whether the HALP score is a prognostic marker in patients with recurrent GBM who were given bevacizumab plus irinotecan.
 Methods: compared survival of followed up our clinic diagnosis and treated irinotecan, according score.
 Results: Median PFS OS 4.5 (0.9-14.9) 8 (0.9-21.3) months, respectively. The median low group was 1.85 (1.3-3.37) high 4.96 months (p=0.03). (9.63 [7.28-11.9]) statistically higher (2.26 [0.88-3.65]) (p
Introduction Cetuximab, an anti-EGFR monoclonal antibody, often cause skin toxicity, most commonly acneiform rash. We present a rare case of glomerulonephritis associated with cetuximab therapy. Case Report A 58-year-old male patient recently completed cetuximab-based chemotherapy for metastatic colorectal adenocarcinoma. He presented acute renal failure, anasarca edema and nephrotic proteinuria. The amount protein in the 24-h urine test was over 15.6 grams. Management & Outcome showed...
Background: Coronary artery anomalies have been reported to show various symptoms ranging from chest pain and dyspnea cardio‐respiratory arrest sudden death. In this study, we attempted assess the changes in QT interval duration dispersion anomalous origins of coronary arteries (AOCA). Methods: Nineteen AOCA patients (mean age: 52 ± 11 years) 30 healthy control subjects 50 12 were included study. Minimum maximum corrected intervals, calculated. The two groups compared terms duration....
This study was an investigation of the role left ventricular (LV) apical rotation seen in early period after myocardial infarction (MI) predicting infarct localization.A total 124 patients with a ST-Segment elevation (STEMI) diagnosis who underwent primary percutaneous coronary intervention (PCI) and 50 healthy volunteers similar demographic characteristics were included study. The relationship between 2-dimenstional speckle tracking echocardiography (STE)-guided LV angle measurements...
Bevacizumab (BEV) is a humanized monoclonal antibody of vascular endothelial growth factor receptors and, as result clinical trials, was approved for the treatment recurrent ovarian cancer (ROC). The aim this study to assess utility BEV in patients with ROC real-world practice beyond trials.In single-center retrospective cohort study, we evaluated medical data all who were treated between October 2013 and March 2020.A total 76 females evaluated. Forty-nine (64.5%) platinum sensitive 27...
Abstract Background We aimed to investigate the effect of radiological complete response on survival outcomes in patients with non-metastatic nasopharyngeal cancer. This study is conducted as a retrospective cohort. Of 185 screened, 60 were metastatic, 25 patients’ data was not available, and result, 92 included study. Among (CR) incomplete (IR) groups, overall (OS), distant metastasis-free (DMFS), locoregional failure-free (LRFFS) evaluated. Results patients, 54 (58.6%) CR 38 (41.4%) IR...
Flaczka to rzadki skórny zespół paraneoplastyczny, który można przeoczyć i często pojawia się w przypadku rogowacenia czarnego. Jeśli u pacjenta występują razem flaki palmowe rogowacenie ciemne, powinien przychodzić na myśl rak żołądka. 50-letnia pacjentka miała objawy bólu brzucha oraz aksamitne zgrubienia dłoniach podeszwach. Flaki czarne uznano za paraneoplastyczny po wykluczeniu innych łagodnych przyczyn. Stwierdzono, że przyczyną nowotworu był Po neoadiuwantowym schemacie flot wykonano...