A5019092976- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Molecular Biology Techniques and Applications
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- COVID-19 and healthcare impacts
- Sexual function and dysfunction studies
- Pancreatic function and diabetes
- Click Chemistry and Applications
- Prenatal Screening and Diagnostics
- RNA and protein synthesis mechanisms
- Platelet Disorders and Treatments
- Healthcare during COVID-19 Pandemic
- Renal cell carcinoma treatment
- COVID-19 diagnosis using AI
- Biosensors and Analytical Detection
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Genomics and Phylogenetic Studies
- SARS-CoV-2 detection and testing
- Healthcare Regulation
Universidade Estadual Paulista (Unesp)
2008-2024
Universidade Positivo
2024
Hospital de Câncer de Barretos
2021
Universidade Estadual de Campinas (UNICAMP)
2001-2015
Universidade Federal de São Paulo
2001
Universidade de São Paulo
2001
Open reading frame expressed sequences tags (ORESTES) differ from conventional ESTs by providing sequence data the central protein coding portion of transcripts. We generated a total 696,745 ORESTES 24 human tissues and used subset that correspond to set 15,095 full-length mRNAs as means assessing efficiency strategy its potential contribution definition transcriptome. estimate sampled over 80% all highly moderately expressed, between 40% 50% rarely genes. In our most thoroughly sequenced...
To evaluate hematological, cytogenetic and molecular responses as well the overall, progression-free event-free survivals of chronic myeloid leukemia patients treated with a third tyrosine kinase inhibitor after failing to respond imatinib nilotinib/dasatinib.Bone marrow karyotyping real-time quantitative polymerase chain reaction were performed at baseline 3, 6, 12 18 months initiation treatment inhibitor. Hematologic, defined according European LeukemiaNet recommendations. BCR-ABL1...
Somatic copy number aberrations (CNAs) have been associated with clear-cell renal carcinoma (ccRCC) pathogenesis and are a potential source of new diagnostic, prognostic therapeutic biomarkers. Recurrent CNAs include loss chromosome arms 3p, 14q, 9p, gains 5q 8q. Some these regional suspected altering gene expression could influence clinical outcomes. Despite many studies in RCC, there currently no descriptions genomic alterations Brazilian ccRCC cohort. This study was designed to evaluate...
Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some also develop dasatinib. To identify potential molecular pathways involved primary dasatinib CML, we analyzed gene expression profiles of mononuclear cells 7 imatinib-resistant patients, collected before and after 1-year treatment. Large-scale was measured Agilent microarrays covering protein-coding genes long (>200 nt) noncoding RNAs...
This is the largest Latin American study of BCR-ABL mutations in chronic myeloid leukemia (CML) patients, resistant to imatinib (IM). In 195/467 (41%) were detected. The most frequent mutation was T315I (n = 31, 16%). Progression-free (PFS) and overall survival (OS) at 5 years lower patients with (43% vs. 65%, p 0.07 47% 72%, 0.03, respectively) those (p 0.003 0.03). OS PFS superior subgroup who switched second generation inhibitors (SGIs) after IM failure (OS: 50% 39% 0.01; PFS: 48% 30%...
Point mutations within the ABL kinase domain are most frequent mechanism for reactivation of activity BCR-ABL gene and have been associated with clinical resistance to tyrosine (TK) inhibitors in patients CML, conferring a poor prognosis. T315I (Treonine-->Isoleucine) is mutation exon 6 that makes protein resistant currently used treating CML. Denaturing High-performance liquid chromatography (D-HPLC) allows high throughput screening. In this study, we screened presenting failure or sub...
Early reduction of BCR-ABL1 transcript levels has been associated with improved outcome in chronic myeloid leukemia (CML) treatment. We evaluated 54 chronic-phase CML patients treated imatinib who switched therapy to dasatinib (n = 33) or nilotinib 21). were measured peripheral blood using real-time quantitative PCR (RQ-PCR) every 3 months from the start second-line Patients BCR-ABL >10% at and >1% 6 had significantly inferior progression-free (PFS) event-free survival (EFS) than...
The polymerase chain reaction of upper respiratory tract swab samples was established as the gold standard procedure for diagnosing SARS-CoV-2 during COVID pandemic. However, saliva collection has attracted attention an alternative diagnostic method. goal this study to compare use and nasopharyngeal (NPS) detection SARS-CoV-2. Ninety-nine paired were evaluated by a qualitative diagnosis quantitative comparison viral particles. Furthermore, limits each sample technique determined. cycle...
Introduction: COVID-19 infection may cause erectile dysfunction due to local viral and impairing mental health. Objective: To analyze the function in Brazilian sample patients during pandemics with without compare results from a obtained before pandemic. Methods: Internet survey epidemiologic questions, data on infection, International Index for Erectile Function (IIEF). Patients were divided into those infections. A control group pandemic was also included. Results: Four hundred twenty-two...
Este trabalho teve por objetivo correlacionar o status quimérico de pacientes pós -TCPH alogênico com parâmetros clínicos, para avaliar valor preditivo dos achados laboratorias quimerismo. Amostras sangue 98 (67 em seguimento e 31 novos casos) foram submetidas à análise do pós-TCPH. Os "loci"analisados biologia molecular CS1PO, TPOX, F13A1, FESFPS, HUMTH01, VWA, SE33, HUMARA, HUMD21S11 Amelogenina. Precocidade da evidência laboratorial quimerismo misto (QM), relação ao aparecimento sintomas...