A5100630961- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Cardiac Imaging and Diagnostics
- Retinopathy of Prematurity Studies
- MicroRNA in disease regulation
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- Aquaculture disease management and microbiota
- Nausea and vomiting management
- Ocular Surface and Contact Lens
- Mesenchymal stem cell research
- Retinal and Optic Conditions
- Anesthesia and Pain Management
- Corneal Surgery and Treatments
- Medical Imaging and Pathology Studies
- Coronary Interventions and Diagnostics
- Heat shock proteins research
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Parathyroid Disorders and Treatments
- Anesthesia and Sedative Agents
- Food Safety and Hygiene
- Machine Learning in Bioinformatics
- Ocular Disorders and Treatments
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2021-2024
First Affiliated Hospital of Xinjiang Medical University
2022-2024
Xinjiang Medical University
2020-2024
Stanford University
2024
Dalian Medical University
2019-2023
First Affiliated Hospital of Dalian Medical University
2019-2023
Huazhong University of Science and Technology
2023
Kunming University of Science and Technology
2023
First Affiliated Hospital of Anhui Medical University
2023
The capacity of self-renewal and multipotent differentiation makes mesenchymal stem cells (MSC) one the most widely investigated cell lines in preclinical studies as cell-based therapies. However, low survival rate poor homing efficiency MSCs after transplantation hinder therapeutic application. Exosomes derived from have shown promising potential many diseases. heterogeneity may lead to differences function secreting exosomes. In this study, effects hUC-Exos hFP-Exos on DSS-induced colitis...
The association between sleep-related disorders and cardiovascular diseases (CVDs) remains controversial lacks epidemiological evidence in the general population. We investigated whether are related to CVDs a large, nationally representative, diverse sample of American adults.Data were collected from National Health Nutrition Examination Survey (NHANES) 2005-2008. Logistic regression was performed explore associations with prevalence total specific CVDs. Stratified subgroup analysis exclude...
Purpose: To identify the spectral domain optical coherence tomography predictors of visual prognosis in retinal vein occlusion macular edema after intravitreal conbercept injection. Methods: Retrospective cohort study 63 treatment-naive eyes received pro re nata with at least 3 months follow-up. The best-corrected acuity (BCVA) and scans were recorded baseline, 1 month, starting therapy. On tomography, following lesions 1-mm-wide area centered on fovea: disorganization inner layer extent,...
Diabetic macular edema (DME) is the complication of diabetic retinopathy, leading cause vision loss among patients. Metformin main antidiabetic treatment. It preferable for its great anti-angiogenic and anti-inflammatory effects. Anti-vascular endothelial growth factor (VEGF) therapy treatment DME despite lack convincing results in some To assess whether combination metformin anti-VEGF drugs may decrease risk resistance We included patients with a central retinal thickness (CRT) ≥ 250 μm who...
Abstract Background Epidural labor analgesia is a safe and effective method of pain management during with the drawbacks delayed onset maternal distress epidural puncture. This study aimed to determine whether pretreatment intranasal low-dose dexmedetomidine effectively shortens reduces procedural pain. Methods In this prospective, randomized double-blind trial, nulliparous patients were randomly assigned either group or control group. The received 0.5 μg/kg intranasally, an equal volume...
Purpose: Retinal pigment epithelial (RPE) cells are highly specialized neural with several functions essential for vision. Progressive deterioration of RPE in elderly individuals can result visual impairment and, ultimately, blinding disease. While human embryonic stem cell-derived cell (hESC-RPE) growth conditions generally harsher than those lines, the subretinal transplantation hESC-RPE is being clinically explored as a strategy to recover damaged retina and improve The cell-adhesion...
<b><i>Background:</i></b> Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder characterized by high androgen levels. The aim of this study was to evaluate the effects hyperandrogenism on hypothalamus subsequently food intake obesity in females. <b><i>Methods:</i></b> A dihydroxy testosterone (DHT)-induced rat model established recapitulate features PCOS patients. Body weight rats were recorded. DHT-induced...
Background In mainland China, patients with neovascular age-related macular degeneration (nAMD) have approximately an 40% prevalence of polypoidal choroidal vasculopathy (PCV). This disease leads to recurrent retinal pigment epithelium detachment (PED), extensive subretinal or vitreous hemorrhages, and severe vision loss. China has introduced various treatment modalities in the past years gained comprehensive experience treating PCV.Methods A total 14 specialists nationwide expertise PCV...
<title>Abstract</title> Objective: This study aimed to develop a prognostic signature for pancreatic cancer (PC) using immune checkpoint-related long non-coding RNAs (lncRNAs) and evaluate their clinical significance in PC patients. Methods: Transcriptome data information of patients were obtained from the Cancer Genome Atlas. Immune genes analyzed identify lncRNAs. Univariate Cox analysis, Lasso multivariate analysis performed select relevant lncRNAs construct signature. Independent...
Purpose: To investigate the impact of intraoperative infusion recombinant human-activated coagulation factor VII (rFVIIa) on postoperative outcomes in patients with acute aortic dissection (AAD). Methods: This study involved 120 individuals who underwent coarctation surgery between January 1, 2020, and December 31, 2022 First Affiliated Hospital Xinjiang Medical University, Xinjiang, China. The participants were divided into control (receiving only conventional treatment) rFVIIa addition to...
OBJECTIVE: To investigate how serum uric acid (SUA) influences the reproductive outcomes among women with polycystic ovary syndrome (PCOS) undergoing freeze-all strategy. DESIGN: Retrospective cohort study. Setting: Reproductive center in a tertiary hospital China. Population: 1115 aged 20-40 years PCOS were included. Method: The entire population was categorized into four groups based on SUA quartiles, logistic regression analysis conducted to determine odds ratios (ORs) for and pregnancy...
Abstract Background Calciphylaxis, which mostly affects individuals with end-stage kidney disease (ESKD), is also known as calcific uremic arteriolopathy (CUA). It a rare and fatal that manifests calcification thrombosis of microvessels, ischemia, necrosis in skin tissues(ORPHA:280062). Histopathological features extracutaneous tissues CUA patients undergoing human amnion–derived mesenchymal stem cell (hAMSC) treatment remain unknown. Methods A female patient, treated hAMSCs for 20 months,...
Minjie Ma, Shangqing Xu, Biao Han, Ning Wei, Lixin Liu, Ruijiang Lin, Wenteng Hu, Peng Yue, Xiong Cao, Hongbing Wang, Hua He, Xiang Zhiwei Han
Lung-protective ventilation (LPV) strategies have been considered as best practice in the care of critically patients.This study aimed to investigate effects individualized perioperative LPV with a positive end-expiratory pressure (PEEP) and low tidal volumes (VT) based on target airway plateau (Pplat) patients during after an operation compared conventional elderly abdominal surgery.Sixty-one American Society Anesthesiologists (ASA) I III undergoing open surgery received either (8...
Diabetic patients often experience visual defects before any retinal pathologies are detected. The molecular mechanism for the in early diabetes has not been elucidated. Our previous study reported that diabetic retinopathy (DR), rhodopsin levels were reduced due to impaired 11-<i>cis</i>-retinal regeneration. Interphotoreceptor retinol-binding protein (IRBP) is a cycle and important generation. IRBP decreased vitreous retina of DR animal models. To determine role downregulation...
Abstract BackgroundAge-related diminished ovarian reserve (AR-DOR) reduced the quality of oocytes, resulting in decreased female fertility. Aging is tightly related to abnormal distribution and function mitochondria, while mitophagy a major process maintain normal quantity mitochondria cells, especially oocytes which containing large number meet demand energy production during oocyte maturation subsequent embryonic development. Ampk/FoxO3a signaling crucial regulation mitophagy. It reported...