A5070629122- MicroRNA in disease regulation
- Renal and related cancers
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- RNA modifications and cancer
- Estrogen and related hormone effects
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Fibroblast Growth Factor Research
- Multiple Myeloma Research and Treatments
- Molecular Biology Techniques and Applications
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Analytical chemistry methods development
Onkologikoa
2024
Biogipuzkoa Health Research Institute
2012-2021
Molecular Oncology (United States)
2017-2018
Tecnalia
2010
Abstract Clear cell tubulopapillary renal carcinoma ( CCPRCC ) is a recently described rare malignancy that displays characteristic gross, microscopic and immunohistochemical differences from other tumour types. However, remains very poorly understood entity. We therefore sought to elucidate some of the molecular mechanisms involved in this neoplasm by carrying out targeted next‐generation sequencing NGS identify associated mutations, addition examined expression non‐coding (nc) RNAs ....
Chronic lymphocytic leukemia (CLL) is an incurable disease accounting for almost one‐third of leukemias in the Western world. Aberrant expression microRNAs (miRNAs) a well‐established characteristic CLL, and robust nature miRNAs makes them eminently suitable liquid biopsy biomarkers. Using nested case–control study within European Prospective Investigation into Cancer Nutrition (EPIC), predictive values five promising human ( hsa‐miR‐16‐5p , hsa‐miR‐29a‐3p hsa‐miR‐150‐5p hsa‐miR‐155‐5p...
Bortezomib action in multiple myeloma: microRNA-mediated synergy (and miR-27a /CDK5 driven sensitivity)?
Early diagnosis of laryngeal squamous cell carcinoma (LSCC) at the stage dysplasia could greatly improve outcome affected patients. For first time we compared mutational landscape non-progressing (NPD; n = 42) with progressing (PD; 24), along patient-matched LSCC biopsies; a total 90 samples. Using targeted next-generation sequencing identified non-synonymous mutations in six genes (PIK3CA, FGFR3, TP53, JAK3, MET, FBXW7), and were validated by Sanger and/or qPCR. Analysis was extended silico...
Prostate cancer (PCa) is the second most common of men and typically slow-growing asymptomatic. The use blood PSA as a screening method has greatly improved PCa diagnosis, but high levels false positives raised much interest in alternative biomarkers. We used next-generation sequencing (NGS) to elucidate urinary transcriptome whole urine collected from high-stage low-stage patients well with confounding diagnosis benign hyperplasia (BPH). identified validated five differentially expressed...
Sunitinib has greatly improved the survival of clear cell renal carcinoma (ccRCC) patients in recent years. However, 20–30% treated do not respond. To identify miRNAs and genes associated with a response, comparisons were made between biopsies from responder non-responder ccRCC patients. Using integrated transcriptomic analyses, we identified 37 60 respective target genes, which significantly NF-kappa B, PI3K-Akt MAPK pathways. We validated expression (miR-223, miR-155, miR-200b, miR-130b)...
Papillary renal neoplasm with reversed polarity (PRNRP) is a recently described rare neoplasm. Traditionally, it was considered variant of papillary cell carcinoma (PRCC). However, several studies reported significant differences between PRNRP and PRCC in terms clinical, morphological, immunohistochemical molecular features. Nonetheless, remains poorly understood entity. We used microarray analysis to elucidate the non-coding RNA (ncRNA) gene expression profiles 10 cases compared them other...
The anti-angiogenic therapy sunitinib remains the standard first-line treatment for meta static clear cell renal carcinoma (ccRCC). However, acquired resistance develops in nearly all responsive patients and represents a major source of failure. We used an integrated miRNA mRNA transcriptomic approach to identify miRNA:target gene interactions involved resistance. Through generation stably resistant clones three ccRCC lines (786-O, A498 Caki-1), we identified non-overlapping networks,...
The main objective of this paper is to address the performance immunochemical assays for detection residues three pesticides [atrazine, bromopropylate, and 2,4,6-trichlorophenol (TCP)] in real winery samples, such as wine, grapes, grape juice. Different approaches have been evaluated minimize interferences from matrixes, suitable working protocols established order achieve necessary LODs, accuracy, precision samples. A simple dilution sample proved be sufficient determination atrazine...
B-cell lymphomas represent a heterogeneous collection of more than twenty-five different malignancies. Classification is often challenging as primarily based upon, sometimes subjective, histopathological criteria and misdiagnosis can result in inappropriate treatment decisions. MicroRNAs (miRNAs) hold great promise novel biomarkers (diagnostic, prognostic predictive) lymphoma addition to being potential therapeutic targets. The most promising these miRNAs not play key regulatory roles...
e11580 Background: The receptor status, Estrogen Receptor (ER), Progesterone (PR) and HER-2 can change between the primary (P) synchronous axillary lymph node (ALN) metastases. frequency of this its clinical significance is poorly known. We have investigated situation in cases with ER positive BC. Methods: retrospectively identified positive, non metastatic BC treated surgery (lumpectomy or mastectomy plus ALN dissection) two centres (Hospital Universitario Donostia Onkologikoa) 2001-2006....
<ns4:p><ns4:bold>Background</ns4:bold>: The outcome for oestrogen receptor positive (ER+) breast cancer patients has improved greatly in recent years largely due to targeted therapy. However, the presence of involved multiple synchronous lymph nodes remains associated with a poor outcome. Consequently, these would benefit from identification new prognostic biomarkers and therapeutic targets. expression G-protein-coupled kinase-interacting protein 1 (GIT1) recently been shown be an indicator...
Paclitaxel is a widely used chemotherapeutic agent for the treatment of breast cancer (BC), including as front-line triple-negative (TNBC) patients. However, resistance to paclitaxel remains one major causes death associated with failure. Multiple studies have demonstrated that miRNAs play role in and are both disease progression metastasis. In present study, we miRNA-encoding lentiviral library gain-of-function screen MDA-MB-231 TNBC cell line. We identified miR-181b, miR-29a, miR-30c,...
Abstract: B-cell lymphomas represent a group of more than 35 recognized mature neoplasms differentiated largely on the basis immunohistochemical staining patterns that are often challenging to accurately diagnose. Despite having been only formally just over 10 years ago, microRNAs (miRNAs) have become one trendiest topics in biology. Dysregulation miRNAs is ubiquitous feature cancer general, including lymphomas. Many aberrantly expressed also play crucial regulatory role normal hematopoietic...
<ns4:p><ns4:italic>Background</ns4:italic>: The outcome for oestrogen receptor positive (ER+) breast cancer patients has improved greatly in recent years largely due to targeted therapy. However, the presence of involved multiple synchronous lymph nodes remains associated with a poor outcome. Consequently, these would benefit from identification new prognostic biomarkers and therapeutic targets. expression G-protein-coupled kinase-interacting protein 1 (GIT1) recently been shown be an...