A5091137983- Reproductive tract infections research
- Urinary Tract Infections Management
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
- Evolution and Genetic Dynamics
- Statistical Methods and Bayesian Inference
- Food Allergy and Anaphylaxis Research
- Essential Oils and Antimicrobial Activity
- Metal complexes synthesis and properties
- Statistical Methods in Clinical Trials
- Phytochemistry and Biological Activities
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Biological and pharmacological studies of plants
- Urticaria and Related Conditions
- Supramolecular Chemistry and Complexes
- Plant and animal studies
- Tryptophan and brain disorders
- Cynara cardunculus studies
- Phytochemical and Pharmacological Studies
- Pelvic floor disorders treatments
- Contact Dermatitis and Allergies
- Nanoparticles: synthesis and applications
- Pharmaceutical and Antibiotic Environmental Impacts
University of Szeged
2013-2024
University of Illinois Chicago
2014
Background: Efficient localized cervicovaginal antibacterial therapy, enabling the delivery of antibiotic to site action at lower doses while escaping systemic drug effects and reducing risk developing microbial resistance, is attracting considerable attention. Liposomes have been shown allow sustained release into vaginal mucosa improve antibiotics bacterial cells biofilms. Azithromycin (AZI), a potent broad-spectrum macrolide antibiotic, has not yet investigated for therapy infections,...
Acquiring resistance against antiviral drugs is a significant problem in antimicrobial therapy. In order to identify novel compounds, the activity of eight plants indigenous southern region Hungary herpes simplex virus-2 (HSV-2) was investigated. The plant extracts and compound carnosic acid were tested for their effectiveness on both extracellular intracellular forms HSV-2 Vero HeLa cells. replication measured by direct quantitative PCR (qPCR). Among extracts, Salvia rosmarinus (S....
Uncontrolled herpes simplex virus 1 (HSV-1) infection can advance to serious conditions, including corneal blindness or fatal encephalitis. Here, we describe a highly potent anti-HSV-1 peptide (DG2) that inhibits HSV-1 entry into host cells and blocks all aspects of infection. Importantly, DG2 is resistant proteases shows minimal toxicity, paving the way for prophylactic therapeutic application in vivo.
Juncaceae species are rich sources of phenanthrenes. The present study has focused on the isolation and structure determination biologically active components from Juncus compressus. Eleven compounds (nine phenanthrenes two flavonoids) have been isolated plant by combination different chromatographic methods. Two (compressins A (Compound 1) B 2)) novel natural products, while seven (effusol 3), effususol 4), juncusol 5), 2-hydroxy-1-methyl-4-oxymethylene-5-vinyl-9,10-dihydrophenanthrene 6),...
ABSTRACT Chlamydiae are obligate intracellular bacteria that propagate in the inclusion, a specific niche inside host cell. The standard method for counting chlamydiae is immunofluorescent staining and manual of chlamydial inclusions. High- or medium-throughput estimation reduction inclusions should be basis testing antichlamydial compounds other drugs positively negatively influence growth, yet low-throughput common approach. To overcome time-consuming subjective counting, we developed an...
infections are the most prevalent sexually transmitted with potentially debilitating sequelae, such as infertility. Mouse models generally used for vaccine development, to study immune response and histopathology associated
In this study, we report the synthesis and characterization of 12 novel rhenium(I) complexes with general formula
In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes general formula [Ru(η6-p-cymene)(X,Y)(Z)] prepared, where (X,Y) represents either an O,O-ligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) Cl− 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested inhibit...
Chlamydia trachomatis (C. trachomatis) is an obligate intracellular bacterium linked to ocular and urogenital infections with potentially serious sequelae, including blindness infertility. First-line antibiotics, such as azithromycin (AZT) doxycycline, are effective, but treatment failures have also been reported. Encapsulation of antibiotics in liposomes considered effective approach for improving their local effects, bioavailability, biocompatibility antimicrobial activity. To test whether...
Chlamydia trachomatis and herpes simplex virus (HSV) are the most prevalent bacterial viral sexually transmitted infections. Due to chronic nature of their infections, they able interact with titanium‐dioxide (TiO2) nanoparticles (NPs) applied as food additives or drug delivery vehicles. The aim this study was describe interactions these two pathogens TiO2 NPs. HSV‐2 were treated nonactivated NPs, silver NPs decorated before infection HeLa Vero cells. Their intracellular growth monitored by...
Neutrophil granulocytes are the major cells involved in Chlamydia trachomatis (C. trachomatis)-mediated inflammation and histopathology. A key protein human intracellular antichlamydial defense is tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) which limits growth of tryptophan auxotroph Chlamydia. Despite its importance, role IDO against neutrophils not well characterized.Global gene expression screen was used to evaluate effect C. serovar D infection on transcriptome...
The transmission of the urogenital serovars Chlamydia trachomatis can be significantly influenced by vaginal gels. Hydroxyethyl cellulose is a commonly used gelling agent that found in
Herpes simplex virus-2 (HSV-2) infections are almost exclusively sexually transmitted. The presence of vaginal gels during sexual activity may have a significant positive or negative impact on viral transmission. Therefore we investigated three off-the-shelf lubricants and one pH restoring gel to evaluate their HSV-2 replication.HeLa cells were infected with untreated virions incubated the particular gels. accumulation genomes was monitored by quantitative PCR (qPCR) method at 24 h post...
Abstract Objective Herpes simplex virus-2 (HSV-2) infections are almost exclusively sexually transmitted. The presence of vaginal gels during the sexual activity may have a significant positive or negative impact on viral transmission. Therefore we investigated three off-the-shelf lubricants and one pH restoring gel to evaluate their HSV-2 replication. Results HeLa cells were infected with untreated virions incubated particular gels. accumulation genomes was monitored by quantitative PCR...
Abstract Objective Herpes simplex virus-2 (HSV-2) infections are almost exclusively sexually transmitted. The presence of vaginal gels during the sexual activity may have a significant positive or negative impact on viral transmission. Therefore we investigated three off-the-shelf lubricants and one pH restoring gel to evaluate their HSV-2 growth. Results HeLa cells were infected with untreated virions incubated particular gels. accumulation genomes was monitored by quantitative PCR (qPCR)...
We provide a Galton--Watson model for the growth of bacterial population in presence antibiotics. assume that cells either die or duplicate, and corresponding probabilities depend on concentration antibiotic. Assuming mean offspring number is given by $m(c) = 2 / (1 + \alpha c^\beta)$ some $\alpha, \beta$, where $c$ stands antibiotic we obtain weakly consistent, asymptotically normal estimator both $(\alpha, \beta)$ minimal inhibitory (MIC), relevant parameter pharmacology. apply our method...