A5020520694- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Thyroid Disorders and Treatments
- Semiconductor materials and devices
- Force Microscopy Techniques and Applications
- Nuclear physics research studies
- Medical Imaging Techniques and Applications
- Superconducting Materials and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Black Holes and Theoretical Physics
- Monoclonal and Polyclonal Antibodies Research
- Integrated Circuits and Semiconductor Failure Analysis
- Radiopharmaceutical Chemistry and Applications
- Psoriasis: Treatment and Pathogenesis
- Inflammatory mediators and NSAID effects
- Animal testing and alternatives
- Peptidase Inhibition and Analysis
- Particle accelerators and beam dynamics
- Occupational and environmental lung diseases
- X-ray Spectroscopy and Fluorescence Analysis
- Immune Cell Function and Interaction
- Vacuum and Plasma Arcs
- Urticaria and Related Conditions
- Particle Accelerators and Free-Electron Lasers
Yokohama City University
2020-2022
Interface (United Kingdom)
2020
A. Alikhanyan National Laboratory
2015-2020
Toyota Central Research and Development Laboratories (Japan)
2003-2018
Maruishi Pharmaceutical (Japan)
2008-2012
RIKEN BNL Research Center
2004
RIKEN
2004
Nagoya University
2003-2004
Tokyo Institute of Technology
2003
University of Cincinnati
2001
To analyze the heterogeneity of anti-TSH receptor antibodies (TSHRAb), we measured serum TSH-binding inhibitory immunoglobulin (TBII), thyroid-stimulating antibody (TSAb), and thyroid stimulation blocking (TSBAb) activities in 31 patients with positive TSHRAb, using CHO cells expressing wild-type TSHR (WT) or chimera (Mc2) wherein residues 90-165 were substituted by LH/CG receptor. Using membranes from WT cells, detected TBII activity all patients; 10 (32%), TSAb only, completely lost Mc2...
A multiplicity of TSH receptor autoantibodies (TSHRAbs) have been characterized after subcloning heterohybridomas produced from the lymphocytes a patient who has Hashimoto's thyroiditis and had three children with intrauterine or neonatal hyperthyroidism. Twelve clones stimulating TSHRAbs that increased cAMP levels iodide uptake in rat FRTL-5 thyroid cells Chinese hamster ovary (CHO) transfected human TSHR; like 95% Graves' TSHRAbs, all 12 their functional epitope on N-terminus TSHR...
The PHENIX collaboration presents a concept for major upgrade to the detector at Relativistic Heavy Ion Collider (RHIC). This upgrade, referred as sPHENIX, brings exciting new capability RHIC program by opening and important channels experimental investigation utilizing fully luminosity of recently upgraded facility. sPHENIX enables compelling jet physics that will address fundamental questions about nature strongly coupled quark-gluon plasma discovered experimentally be perfect fluid....
We report preliminary results on the analysis of three-body Y(10860)=> B barB pi, Y(10860) => (B barB* + c.c.) pi and B* decays including an observation Zb(10610)+- pi-+ [B barB*+c.c]+- Zb(10650)+- [B* barB*]+- as intermediate channels. measure branching fractions to be Br(Y(10860)=> barB*+c.c.]+- pi-+)=(28.3+-2.9+-4.6)x10^{-3} pi-+)=(14.1+-1.9+-2.4)x10^{-3} set 90% C.L. upper limit barB]+- pi-+)<4.0x10^{-3}. also amplitude Y(10860)=>Y(nS)pi+pi-, n=1,2,3 internal structure...
We examined the relationship between blocking type anti-TSH receptor antibody (TRAb) and stimulating TRAb by trying to convert stimulatory in vitro. Immunoglobulins (IgGs) purified from sera of six patients with primary hypothyroidism blocked bovine TSH (100 microU/ml)-induced cAMP production (58.3-82.1% inhibition) cultured porcine thyroid cells. None these IgGs showed activity even after their dilution. In conversion experiment, cells were first incubated at 34 degrees C for 30 min then...
A validation study on an in vitro skin irritation assay was performed with the reconstructed human epidermis (RhE) LabCyte EPI-MODEL24, developed by Japan Tissue Engineering Co. Ltd (Gamagori, Japan). The protocol that followed current optimised version of EpiSkin (LabCyte assay). According to United Nations Globally Harmonised System (UN GHS) classification for assessing potential a chemical, 12 irritants and 13 non-irritants were validated minimum six laboratories from Japanese Society...
Abstract Immunization of AKR/N mice with murine fibroblasts, transfected the TSH receptor (TSHR) and a major histocompatibility complex class II molecule having same H-2k haplotype (but not either alone), induces immune thyroid disease humoral histological features human Graves’, including presence two different TSHR antibodies (TSHRAbs): stimulating TSHRAbs, which cause hyperthyroidism; TSH-binding-inhibiting immunoglobulins. The primary functional epitope for both types in Graves’ patients...
Psoriasis is a systemic, chronic, immunologically-mediated disease affecting approximately 2%-4% of the worldwide population. It well known that psoriasis associated with several comorbidities such as metabolic syndrome, cardiovascular disease, and malignancy. Although meta-analyses large prospective cohort studies have shown an increased risk malignancies in patients worldwide, association between malignancy onset has not yet been established Japan. We retrospectively analyzed 360 at our...
The effects of bovine thyrotropin (TSH) on DNA synthesis and cyclic AMP production were studied in porcine thyroid follicles using suspension culture. During the early 72 hours incubation, time-dependent uptake [3H] thymidine by was obserbed. In presence 10mU/ml TSH, significantly depressed at 72hours incubation. TSH inhibition incorporation related to its concentration 50% observed 1.0mU/ml TSH.Under same conditions, stimulated stimulation be concentration. these experiments, incubation...
The impacts of threading dislocations, surface defects, donor concentration, and schottky Schottky barrier height on the reverse IV characteristic silicon carbide (SiC) junction (JBS) diodes were investigated. 100 A JBS fabricated 4H-SiC 3-inch N-type wafers with two types dislocation density. typical densities are 0.2×104 3.8×104 cm-2, respectively. improvement vIt was found that variations in leakage current high yield large area werecould be obtained improved by using a wafer low In range...
Abstract Phototherapy and apremilast (oral phosphodiesterase‐4 inhibitor) are well‐known in the treatment of moderate to severe psoriasis vulgaris. However, current evidence on efficacy safety their combination is not sufficient. This multicenter, randomized controlled study compared between phototherapy as monotherapy therapy patients with Patients vulgaris were assigned ( n = 29) 13) groups. All underwent an 8‐week regimen comprising irradiation narrowband UV‐B. The group also administered...
Extended X-ray absorption fine structure (EXAFS) spectroscopy is demonstrated to measure the atomic of SiO2–SiC interfaces. The SiC-side interface can be measured by fabricating thin SiO2 films and using SiC-selective EXAFS measurements. Fourier transforms oscillations spectra correspond radial-structure functions reveal a new peak first nearest neighbor Si for m-face SiC, which does not appear in measurements Si-face. This finding suggests that could include with shorter Si–C distances....
A sensitive assay procedure for immunoenzymometric of serum thyrotropin (TSH) was developed by making several modifications the Enzymun-Test TSH kit (Boehringer, Mannheim GmbH). Serum samples were first incubated in plastic tubes precoated with monoclonal antibodies specific to beta subunit human TSH. After washed, bound detected peroxidase-conjugated polyclonal The sensitivity 0.2 milli-int. unit/L, and intra-and interassay CVs less than 10%. Analytical recovery 96 106%. normal basal range...
A new single-sided silicon strip detector has been developed for the vertex tracker of PHENIX at Relativistic Heavy Ion Collider in Brookhaven National Laboratory (BNL). The novel "stripixel" concept by BNL Instrumentation Division was applied to first prototype sensor. feature stripixel is two-dimensional (2-D) position sensitivity with processing achieved charge sharing between two interleaved electrodes one pixel. Signals are read out projectively double layers aluminum strips. sensors...
The differential cross section for the process $γγ\to π^0 π^0$ has been measured in kinematic range 0.6 GeV $< W < 4.1$ GeV, $|\cos θ^*|<0.8$ energy and pion scattering angle, respectively, $γγ$ center-of-mass system. results are based on a 223 fb$^{-1}$ data sample collected with Belle detector at KEKB $e^+ e^-$ collider. Using $W > 1.4$ we obtain light-quark resonances charmonia. We also compare observed angular dependence ratios of sections neutral-pair charged-pair production...
Chemical-state-selective Si K-edge extended X-ray absorption fine structure (EXAFS) measurements of SiO2 and SiC are demonstrated by detecting bond-specific Auger electrons in coated with a very thin film. Differential-electron-yield (DEY) mode is used for the measurements. Each EXAFS spectrum may be subject to following two spectrally overlapping influences: (i) background formed energy-losing overlaps peak, (ii) resonant peak peak. The SiO2- SiC-selective DEY–EXAFS spectra differ from each...
We have demonstrated the detection of nanometer-scale current-leakage sites in electrically stressed gate SiO 2 films using a conductive atomic force microscope (C-AFM). Prior to C-AFM observations, metal-oxide-semiconductor capacitors were subjected constant-current Fowler-Nordheim (FN) stress. Details image contrasts and relationship between surface topography current examined. Two types contrast clearly observed image: sharp bright spot reflecting local leakage caused by hole trapping at...
We previously developed a radioreceptor assay which is presumably specific for detection of blocking-type anti-TSH receptor (TSHR) antibodies using unsolubilized porcine TSHR. Employing this assay, we measured blocking TSH-binding inhibitory immunoglobulin (TBII) in the sera from 30 untreated Graves' patients and compared results with those bioassay measuring thyroid stimulation (TSBAb). Blocking TBII was positive 9 (30%) activity correlated total value, by solubilized On other hand, TSBAb...
We have developed a method of microscopically analyzing the degradation gate SiO2 films in actual metal-oxide-semiconductor (MOS) devices by conductive atomic force microscopy (C-AFM). In C-AFM images electrically stressed films, leakage current spots on nanometer scale were successfully observed. The observed show characteristic behaviors similar to transient stress-induced which can be detected macroscopic electrical measurements using MOS capacitors. appearance is discussed basis...