A5019835802- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Telomeres, Telomerase, and Senescence
- Lipid metabolism and disorders
- Autophagy in Disease and Therapy
- Antimicrobial Peptides and Activities
- Genomics, phytochemicals, and oxidative stress
- Urticaria and Related Conditions
- Dermatologic Treatments and Research
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Retinoids in leukemia and cellular processes
- Molecular Biology Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Cervical and Thoracic Myelopathy
- Renal cell carcinoma treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Acute Kidney Injury Research
- Stress Responses and Cortisol
- Healthcare and Venom Research
- NF-κB Signaling Pathways
Huazhong University of Science and Technology
2012-2024
Wuhan No.1 Hospital
2020-2024
Gansu Provincial Hospital
2016-2024
Hubei University of Chinese Medicine
2020-2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
Huangshi Central Hospital
2020
Hubei Polytechnic University
2020
University of South China
2015
Central South University
2010-2011
Insulin resistance (IR) plays a major role in the pathogenesis of abdominal obesity, hypertension, coronary heart disease, atherosclerosis and diabetes. miR-21 TGF-β/smads is closely related to IR. However, it remained elusive whether metformin improved skeletal muscle insulin (IRSM) by regulating its target signal TGF-β1/smads expression. In this study, high-fat diet rats with IR model IR-skeletal L6 cells (L6-SMCs) were established, sensitive index (ISI) Homeostasis assessment (HOMA-IR)...
Melasma, a common, acquired facial pigmentation skin disorder, presents straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes melasma remain elusive, and the current therapeutic approaches predominantly encompass pharmaceutical laser interventions, with limited efficacy. Transdermal administration stands as prevalent treatment method for melasma, often facilitated by application microneedles. Among these, tranexamic acid...
<i>Background:</i> Inflammatory cytokines such as tumor necrosis factor receptor 2 (TNFR2) and Toll-like (TLR2) are the main responsible mediators of inflammatory acne. Factors affecting their production may possibly influence degree response hence account for clinical severity However, roles TNFR2 TLR2 in pathophysiology acne vulgaris poorly understood. We therefore investigated relationship between susceptibility polymorphisms M196R well Arg753Gln gene....
Androgens acting through the androgen receptor play a crucial role in pathogenesis of acne. This study aimed to identify whether two key genes (CYP21A2 and CYP19A1) involved synthesis metabolism androgens were associated with Pillsbury III-IV severe acne vulgaris.We carried out standard questionnaire survey about enlisted 600 vulgaris patients 652 healthy controls Han Chinese descent from Yunnan, China study. Twenty-two single nucleotide polymorphisms (SNPs) genotyped by SNaPshot assay...
We found in the present study that treatment with ox-LDL decreased cell viability and content of nitric oxide (NO) activity synthase (NOS) as well eNOS mRNA expression, while increasing expression endothelin-1 (ET-1) human umbilical vein endothelial cells (HUVECs). However, endomorphins EM1/EM2 increased NO NOS decreasing ET-1 compared alone. Meanwhile, expressions JNK p-JNK were enhanced by being suppressed EM1/EM2. The results suggested EM1 EM2 can correct dysfunction induced protective...
To study the efficacy of Ba Zhen Tang in delaying skin photoaging and its potential mechanism based on network pharmacology molecular docking.First, we screened active components targets by Traditional Chinese Medicine Database Analysis Platform (TCMSP) The Universal Protein Resource (UniProt). target genes were obtained from GeneCards GeneMap database. Then, analyzed protein-protein interaction (PPI) STRING map was constructed Cytoscape. Finally, performed Gene Ontology (GO) enrichment...
Widespread intra-peritoneal metastases is a main feature of high grade serous ovarian carcinoma (HGSOC). Recently, the extent tumour heterogeneity was used to evaluate cancer genomes among multi-regions in HGSOC. However, there no consensus on effect evolution metastasis process HGSOC.We performed whole-exome sequencing multiple regions matched primary and metastatic HGSOC specimens reveal genetic mechanisms tumourigenesis malignant progression.63 samples (including carcinoma, omentum...
Objective: Artesunate, a semi-synthetic derivative of artemisinin, exerts various pharmacological activities. Nevertheless, the effects Art on skin photoaging remain unclear. Herein, we investigated whether ameliorated ultraviolet-irradiated in HaCaT cells and mice. Methods: To construct cellular models, were irradiated by UV (UVB, 20mJ/cm2) for 5 days. pretreated with three concentrations (1, 20 μg/ml) 2 h each day. After days, cell senescence, ROS production, SOD levels, p16INK4a...
To study the relationship between single nucleotide polymorphisms (SNPs) of human β-defensin 1-gene (DEFB1) and genetic susceptibility acne vulgaris in Han Chinese ethnic group.A total 104 patients with 126 healthy participants were included our study. We analyzed association DEFB1 G-52A, C-44G, G-20A gene. then different genotypes to vulgaris.The frequency C-44G group control was significantly (P < 0.05). The also 0.05).The -44G or -20A allele showed a low expression vulgaris, which has...
Rosacea is a chronic inflammatory dermatosis that primarily affects the facial vasculature, nerves, and pilosebaceous units. This case report describes of refractory rosacea associated with ultra-high-density Demodex folliculorum (DF) colonization its specific skin imaging findings. The patient was middle-aged man 1.5-year history erythema, papules pustules itching dryness. Reflectance confocal microscopy (RCM) revealed number DF reached an average 40 within area 4 mm² perifollicular...
Abstract Aims To evaluate the status quo of type 1 diabetes (T1D) management and characteristics hospitalised patients with T1D in China through a nationwide multicentre registry study, Diabetes Type Study (CD1S). Materials Methods Clinical data from electronic hospital records all people were retrospectively collected 13 tertiary hospitals across 7 regions January 2016 to December 2021. Patients defined as newly diagnosed who received diagnosis for less than 3 months. Results Among 4993...
Objective To investigate the effect of highly expressed β-catenin on proliferative activity and expressions two apoptosis-related genes Bcl-2 Bax by human skin fibroblasts induced hydrogen peroxide（H2O2）. Methods Normal fibroblasts（HSFs）from child foreskin were divided into three groups: empty vector group transfected with pcDNA3.1, H2O2 pcDNA3.1 followed treatment H2O2（150 μmol/L）for 2 hours, pcDNA3.1-β-catenin hours. Subsequently, methyl thiazolyl tetrazolium（MTT）assay was conducted...
Objective To investigate clinical curative effect of partial foraminotomy after C4,5 ossification posterior longitudinal ligament (OPLL) on preventing C5 nerve root palsy. Methods A total 155 patients with OPLL were treated expansion open-door laminoplasty (EOLP) between January 2008 and October 2012, including 75 male 80 female patients, average age 54.5 (ranging from 38 to 75). Among them, 90 cases took EOLP (open team), 65 (incision team). Clinical imaging evaluation used in 8...
Objective To observe the changes of β-catenin expression in human skin fibroblasts (HSFs) after induced by oxidative stress, and to explore its possible roles stress-induced premature senescence (SIPS) HSFs. Methods Fibroblasts were isolated from foreskin a child subjected primary culture. The second fourth passage treated with various concentrations H2O2 for 2 hours establish an optimized model senescence, β-galactosidase assay kit was used detect activity H2O2rinduced HSFs, RT-PCR Western...