A5012554782- Salivary Gland Disorders and Functions
- Radiation Effects in Electronics
- Integrated Circuits and Semiconductor Failure Analysis
- Semiconductor materials and devices
- Pancreatic function and diabetes
- Antenna Design and Optimization
- Microwave Engineering and Waveguides
- Glycosylation and Glycoproteins Research
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
- Developmental Biology and Gene Regulation
- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Proteoglycans and glycosaminoglycans research
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Chromosomal and Genetic Variations
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Antenna Design and Analysis
- Superconducting and THz Device Technology
- Connexins and lens biology
- Asthma and respiratory diseases
- Genetic and Kidney Cyst Diseases
Nagoya Institute of Technology
2022-2025
Nihon University
2012-2023
John Hunter Hospital
2023
New Zealand Association of Counsellors
2023
Mitsubishi Heavy Industries (Japan)
2016-2020
Niigata University
2007-2017
Nagasaki Kawatana Medical Center
2017
National Institute of Genetics
2007-2016
Nagoya University
2008-2016
The University of Tokyo
1982-2015
The medaka fish (Oryzias latipes) is a popular pet in Japan and more recently laboratory model organism for developmental genetics evolutionary biology. Now the medaka's genome has been sequenced analysed by large Japanese consortium. Cichlids stickleback, which are emerging systems understanding genetic basis of vertebrate speciation, evolutionarily closer to than zebrafish, so sequence will yield valuable insights into 400 million years evolution. long organism; it now its Teleosts...
Single-event upset (SEU) hardness varies across dies, wafers, and lots—even just after fabrication further time. Mechanisms of postfabrication variations include total ionizing dose (TID) effects, which are caused by long-term radiation exposure. This synergistic effect TID on SEU is a particular concern in integrated circuits used space nuclear environments. article shows that an electrical parameter called the data-retention voltage useful dealing with such effects static random access...
Among mammals, only eutherians and marsupials are viviparous have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis investigate the origin of in mammals. PEG10 (paternally expressed 10) is a retrotransposon-derived imprinted has an essential role for formation placenta mouse. Here, we show orthologue exists another therian mammal, marsupial tammar wallaby (Macropus eugenii), but not prototherian egg-laying platypus...
The Solanaceae family includes several economically important vegetable crops. tomato (Solanum lycopersicum) is regarded as a model plant of the family. Recently, number resources have been developed in parallel with ongoing genome sequencing project. In particular, miniature cultivar, Micro-Tom, system genomics, and genomics Micro-Tom-background, such ESTs mutagenized lines, established by an international alliance. To accelerate progress we collection fully-sequenced 13,227 Micro-Tom...
The aim of this study was to obtain new Lactococcus lactis strains from nondairy materials for use as milk fermentation starters. genetic and phenotypic traits the obtained were characterized compared with those L. derived milk. It confirmed that plant-derived bacteria could be used starters.About 2600 lactic acid subjected screening species-specific PCR. Specific DNA amplification observed in 106 isolates. Forty-one selected, including 30 milk-derived 11 plant-derived, their profiles...
Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their are derived predominantly the Western European subspecies Mus musculus domesticus, remaining mostly Japanese molossinus. However, it remains unknown how this intersubspecific genome introgression occurred during establishment of strains. In study, we resequenced two M. m. molossinus-derived strains, MSM/Ms and JF1/Ms. originated wild mice, ancestry JF1/Ms was originally...
Recent studies have revealed that a cilium‐generated liquid flow in the node has crucial role establishment of left‐right (LR) axis mouse. In fish, Kupffer's vesicle (KV), teleost‐specific spherical organ attached to tail region, is known an equivalent mouse during LR formation. However, at present, there been no report asymmetric gene expressed KV under control fluid flow. Here we earliest teleost KV, medaka charon , and its regulation. Charon member Cerberus/DAN family proteins, first...
Abstract Background Body coloration is an ecologically important trait that often involved in prey-predator interactions through mimicry and crypsis. Although this subject has attracted the interest of biologists general public, our scientific knowledge on remains fragmentary. In caterpillar swallowtail butterfly Papilio xuthus , spectacular changes color pattern are observed; insect mimics bird droppings (mimetic pattern) as a young larva, switches to green camouflage (cryptic final instar....
Abstract The proinflammatory cytokine interleukin 1β (IL-1β) induces prostaglandin E 2 (PGE ) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. This effect IL-1β is involved osteoarthritis. We investigated MAPK signaling pathways IL-1β-induced COX-2 feline In the presence inhibitors, and PGE release were both attenuated. induced phosphorylation p38, JNK, MEK, ERK1/2. A JNK inhibitor prevented not only but also MEK ERK1/2 IL-1β-stimulated cells,...
Salivary fluid secretion involves an intricate choreography of membrane transporters to result in the trans-epithelial movement NaCl and water into acinus lumen. Current models are largely based on experimental observations enzymatically isolated cells where Ca 2+ signal invariably propagates globally thus appears ideally suited activate spatially separated Cl K channels, present apical basolateral plasma membrane, respectively. We monitored signals salivary live mice expressing GCamp6F,...
A hybrid two-dimensional (2D) beam-scanning lens antenna through the combination of a mechanical slide and phased array primary radiator is proposed. The proposed allowed for scanning main beam in one dimension by utilizing piezo motor to lens, while also enabling electrical radiators arranged orthogonal direction. effectiveness was demonstrated electromagnetic simulations fabricated measurements. We have shown capability perform 2D with scan loss approximately 3 dB over spherical angular...
Aquatic mosses in the genera Bryum and Leptobryum form unique tower-like "moss pillars" underwater some Antarctic lakes, association with algae cyanobacteria. These are communities a two-layer structure comprising an oxidative exterior reductive interior. Although habitats photosynthetic properties of moss pillars have been reported, microfloral composition has not described. Here we report fatty acid analysis one pillar molecular phylogenetic analysis, based on 16S rRNA gene, this other...
Calcium carbonate biominerals participate in diverse physiological functions. Despite intensive studies, little is known about how mineralization initiated organisms.We analyzed the medaka spontaneous mutant, ha, defective otolith (calcareous ear stone) formation. ha lacks a trigger for mineralization, and causative gene was found to encode polyketide synthase (pks), multifunctional enzyme mainly bacteria, fungi, plant. Subsequent experiments demonstrate that products of PKS, most likely...
Abstract Matrix metalloproteinase‐3 (MMP‐3) expression is promoted after pulpotomy, and application of MMP‐3 to dental pulp pulpotomy accelerates angiogenesis hard tissue formation. However, the mechanism by which promotes wound healing still unclear. Connective growth factor/CCN family 2 (CTGF/CCN2), a protein belonging CCN family, considered participate in healing, angiogenesis, cell migration. In this study, we examined involvement CTGF/CCN2 MMP‐3‐induced migration human (fibroblast‐like)...
Summary Background In vitro ‐derived human mast cells exhibit different properties, depending in part on the source of progenitor cells. Most investigations have used fetal liver, cord blood or peripheral blood. Few adult bone marrow. Objective Human derived from CD34 + progenitors marrow and that had been cultured with recombinant stem cell factor (rhSCF) interleukin‐6 (rhIL‐6) were compared. Methods results After 12 weeks culture, nearly all cells, these cytoplasmic granules containing...
Medaka ( Oryzias latipes ) is a small egg-laying freshwater teleost native to East Asia that has become an excellent model system for developmental genetics and evolutionary biology. The draft medaka genome sequence (700 Mb) was reported in June 2007, its substantial genomic resources have been opened the public through University of Tokyo Genome Browser (UTGB/medaka) database. This database provides basic information, such as predicted genes, expressed tags (ESTs), guanine/cytosine (GC)...
Polycystic kidney disease (PKD) is a common hereditary in humans. Recent studies have shown an increasing number of ciliary genes that are involved the pathogenesis PKD. In this study, Gli-similar3 (glis3) gene was identified as causal medaka pc mutant, model transposon found to be inserted into fourth intron pc/glis3 gene, causing aberrant splicing mRNA and thus putatively truncated protein with defective zinc finger domain. expressed epithelial cells renal tubules ducts pronephros...
We investigated the in vitro differentiation of canine bone marrow stromal cells (BMSCs) into voltage- and glutamate-responsive neuron-like cells. BMSCs were obtained from healthy beagle dogs. Canine incubated with basal medium for neurons containing recombinant human basic fibroblast growth factor (bFGF; 100 ng/ml). The viability bFGF-treated was assessed by a trypan blue exclusion assay, morphology monitored. Real-time RT-PCR performed to evaluate mRNA expression neuronal, neural stem cell...
Abstract We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes ), which turned out to mutation the chordin gene. The exhibits ventralization of body axis, malformation axial bones, over‐bifurcation yolk sac blood vessels, laterality defects internal organs. variability phenotypes, depending on culture temperature, from embryos with slightly phenotype those without any head trunk structures. Taking advantages these variable severe we...
Silicon-on-insulator technology is often used to develop high-reliability devices with low sensitivity single-event upsets or soft errors. Its key component, the buried-oxide (BOX) layer, now thinned down 10 nm. This thinning enables transistors on layer be efficiently conditioned by back-bias voltages fed underneath layer. However, a little known about influence of such conditioning errors caused heavy ion radiation. A static random access memory supported 10-nm-thick BOX was exposed...