A5011970350- Nutritional Studies and Diet
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Hormonal and reproductive studies
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Urinary Bladder and Prostate Research
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Inflammatory Biomarkers in Disease Prognosis
- Biliary and Gastrointestinal Fistulas
- Nutrition, Genetics, and Disease
- Gallbladder and Bile Duct Disorders
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Eating Disorders and Behaviors
- Bladder and Urothelial Cancer Treatments
- Sexual Differentiation and Disorders
- Esophageal and GI Pathology
- Cardiovascular Disease and Adiposity
- Pediatric Hepatobiliary Diseases and Treatments
Fred Hutch Cancer Center
2016-2025
Seattle University
2009-2019
GTx (United States)
2019
Cancer Research Center
2014-2018
University of Washington
2007-2016
The University of Texas Health Science Center at San Antonio
2016
University of Colorado Denver
2016
American University of Beirut
2016
Praxis
2015
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2008-2015
Outcomes from protocol-directed active surveillance for favorable-risk prostate cancers are needed to support decision-making.
We examined risk factors for incident symptomatic benign prostate hyperplasia in 5,667 Prostate Cancer Prevention Trial placebo arm participants who were free of prostatic at baseline.During 7 years symptoms assessed annually using the International Symptom Score and treatment was quarterly by structured interview. Total defined as receipt or report 2 values greater than 14. Severe 20 greater. Weight body circumferences measured trained staff demographic health related characteristics...
This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994-2003) placebo-arm participants who were free of BPH at baseline. was assessed over 7 years and defined as medical or surgical treatment repeated elevation (>14) on the International Symptom Score questionnaire. Diet, alcohol, supplement use by a food frequency There 876 cases (33.6/1,000 person-years). The hazard ratios contrasts highest to lowest quintiles...
Abstract Background:In vitro, animal, and ecological studies suggest that inadequate vitamin D intake could increase prostate cancer risk, but results of biomarker-based longitudinal are inconsistent. Methods: Data for this case (n = 1,731) cohort 3,203) analysis from the Selenium Vitamin E Cancer Prevention Trial. Cox proportional hazard models were used to test whether baseline plasma (25-hydroxy) concentration, adjusted season blood collection, was associated with risk total Gleason score...
<h3>Importance</h3> African American men have the highest rates of prostate cancer incidence and mortality in United States. Understanding underlying reasons for this disparity could identify preventive interventions important to men. <h3>Objective</h3> To determine whether association obesity with risk differs between non-Hispanic white modifies excess associated race. <h3>Design, Setting, Participants</h3> Prospective study 3398 22 673 who participated Selenium Vitamin E Cancer Prevention...
The authors conducted a nested case-control study of serum inflammatory markers and risk symptomatic benign prostatic hyperplasia (BPH), using data from the placebo arm Prostate Cancer Prevention Trial (1993–2003). Incident BPH (n = 676) was defined as treatment, report 2 International Symptom Score (IPSS) values >14, or increases ≥5 baseline with at least one value ≥12. Controls 683) were men who reported no treatment IPSS >7 over 7-year trial. Baseline analyzed for C-reactive protein,...
Abstract Background: Epidemiologic studies have reported inconsistent associations of vitamin D and prostate cancer risk; however, few adequately controlled for detection bias related to prostate-specific antigen (PSA) screening, the results many may be affected by occult cancers among controls. Methods: Data this nested case–control analysis (n = 1,695 cases/1,682 controls) are from Prostate Cancer Prevention Trial. Baseline serum was analyzed 25-hydroxyvitamin [25(OH)D]. The presence or...
Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and were examined in a consortium of 15 cohort studies. During follow-up, 52,683 incident cases, including 4,924 advanced identified among 842,149 men. Cox proportional hazard models used calculate study-specific relative risks (RR) then pooled using random effects models. Results do not support substantial effect total red, unprocessed red processed for all outcomes, except...
Abstract Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, association genetically predicted is not known. We investigated calculated free and measured total sex hormone‐binding globulin (SHBG) aggressive, overall early‐onset prostate cancer. In blood‐based analyses, odds ratios (OR) 95% confidence intervals (CI) for cancer were estimated using conditional logistic regression from prospective analysis...
Abstract Background Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, association genetically predicted IGF-I aggressive is not known. We aimed investigate IGF-I, IGF-II, IGFBP-1, IGFBP-2 IGFBP-3 concentrations overall, early-onset cancer. Methods Prospective analysis biomarkers using Endogenous Hormones, Nutritional Biomarkers...
The authors conducted a nested case-control study of serum steroid concentrations and risk benign prostatic hyperplasia (BPH), using data from the placebo arm Prostate Cancer Prevention Trial (1993–2003). Incident BPH over 7 years (n = 708) was defined as receipt treatment, report 2 International Symptom Score (IPSS) values greater than 14, or increases 5 more baseline IPSS with at least 1 value equal to 12. Controls 709) were selected men who reported no treatment any 7. Baseline analyzed...
This study examined the association between symptomatic benign prostatic hyperplasia (BPH) and prostate cancer risk in 5,068 placebo-arm participants enrolled Prostate Cancer Prevention Trial (1993–2003). These data include 1,225 men whose was detected during 7-year trial—556 for cause (following abnormal prostate-specific antigen or digital rectal examination) 669 not (without indication), as well 3,843 who had biopsy-proven absence of at trial end. Symptomatic BPH assessed hierarchically...
Highlights•Few have examined the role of early adulthood BMI and adult changes on risk advanced forms prostate cancer.•Height in mid/late was positively associated with cancer mortality.•BMI waist circumference mortality.•Change from to were not mortality.AbstractBackgroundAdvanced etiology is poorly understood. Few studies associations anthropometric factors (e.g. obesity) risk.Patients methodsWe carried out pooled analyses examine between body fatness, height, risk. Among 830 772 men, 51...
Abstract BACKGROUND: Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, authors examined associations of total alcohol, type alcoholic beverage, drinking pattern with risk total, low‐grade, high‐grade cancer. METHODS: Data for study came from 2129 participants in Prostate Cancer Prevention Trial (PCPT) who had detected during 7‐year trial 8791 men were determined by biopsy to be free at end. Poisson regression was used...
Introduction Sex hormones have been implicated in the etiology of a number diseases. To better understand disease and mechanisms disease-risk factor associations, this analysis aimed to investigate associations anthropometric, sociodemographic behavioural factors with range circulating sex hormone-binding globulin. Methods Statistical analyses individual participant data from 12,330 male controls aged 25–85 years 25 studies involved Endogenous Hormones Nutritional Biomarkers Prostate Cancer...
Background: Some observational studies suggest that a higher selenium status is associated with lower risk of prostate cancer but have been generally too small to provide precise estimates associations, particularly by disease stage and grade. Methods: Collaborating investigators from 15 prospective provided individual-participant records (from predominantly men white European ancestry) on blood or toenail concentrations risk. Odds ratios concentration were estimated using...
The objective of this study was to examine (ghrelin and peptide YY [PYY]) subjective appetite measures following 21-day high low eating frequency (EF) interventions among healthy adults. In the randomized crossover trial (Frequency Eating Satiety Hormones [FRESH] study), participants completed two eucaloric periods (3 meals/day) (6 EF with a 14-day washout period. Self-selected foods total energy consumed were identical in both arms. On day 21 each period, 7-h clinic visit meals provided...