A5101802417- Cancer Immunotherapy and Biomarkers
- Multimedia Communication and Technology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences Research and Education
- Library Science and Information Literacy
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Immunotherapy and Immune Responses
- Gastrointestinal disorders and treatments
- Academic Writing and Publishing
- Esophageal and GI Pathology
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Artificial Intelligence in Law
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- CAR-T cell therapy research
- Genetic Associations and Epidemiology
Huntsman (United States)
2025
Huntsman Cancer Institute
2024
Moffitt Cancer Center
2014-2023
Gilead Sciences (United States)
2023
Tri-Service General Hospital
1994-2020
Yale University
2020
University of Utah
2018
Alba Graduate Business School, The American College of Greece
2014
Stanford University
2008-2014
State of The Art
2012
We present a multicenter study of new endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle (Acquire, Boston Scientific, Natick, MA). The aim the was to analyze needle's clinical performance when sampling solid lesions and assess safety this device.We performed retrospective patients undergoing EUS-FNB during July 1-November 15, 2016.Two hundred (121 males 79 females) underwent with Acquire needle. Lesions included pancreatic masses (n = 109), adenopathy 45), submucosal 34),...
Understanding the regulatory landscape of human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie non-protein-coding regions, implicating DNA elements as functional targets susceptibility variants. Here, we describe genome-wide annotation regions open chromatin and histone modification fallopian tube ovarian surface epithelial cells (FTSECs, OSECs), debated cellular origins high-grade serous cancers (HGSOCs)...
Magrolimab is a monoclonal antibody that blocks CD47, 'do not eat me' signal overexpressed on tumor cells. CD47 in multiple myeloma (MM), which contributes to its pathogenesis. Preclinical studies have shown blockade induces macrophage activation, resulting elimination of cells, and there synergy between magrolimab certain anticancer therapies. These findings suggest magrolimab-based combinations may therapeutic benefit MM. This phase II study investigates combination with commonly used...
A 37-year-old woman presented with left lower quadrant pain and vaginal spotting 1 month after hysterectomy right salpingo-oophorectomy, which were performed for hemoperitoneum related to a ruptured corpus luteum. An 8-cm ovarian mass was removed that had microcystic, mucoid sectioned surface. Histological examination revealed the consisted of massive foreign-body granulomatous reaction oxidized cellulose (Surgicel). To our knowledge, this is only second report an Surgicel granuloma.
Osteopontin (OPN) and epidermal growth factor receptor (EGFR) are important factors associated with tumor progression, invasion metastasis in humans. The aim of this study was to assess the correlation OPN EGFR expression hepatocellular carcinoma (HCC) progression. Expression assessed by immunohistochemistry 100 HCC specimens. Immunostaining scores (0 400) were calculated from percentage cells 100) at each immunostaining intensity 4). average score for correlated grade (56.1 I, 104.6 II,...
9011 Background: Nivolumab, an IgG4 fully human monoclonal antibody against checkpoint protein PD-1, is active in metastatic melanoma, renal cell and non-small lung cancer. It was administered with a multi-peptide vaccine to patients (pts) unresectable melanoma who failed at least one regimen for disease were ipilimumab naïve, or ipilimumab, assess the toxicity tolerability of combination perform correlative immune assays. Methods: Three cohorts 10 HLA A0201 positive ipilimumab-naïve pts...
Background and Study Aims. The nonlifting polyp sign of invasive colon cancer is considered highly sensitive specific for extending beyond the mid-submucosa. However, prior interventions can cause adenomas to become due fibrosis. It unclear whether be successfully treated endoscopically. aim this study was evaluate outcomes in a referral practice incorporating standardized protocol attempted endoscopic resection lesions previously by biopsy, polypectomy, surgery, or tattoo placement....
Abstract Background Leptomeningeal disease (LMD) occurs as a late complication of several human cancers and has no rationally designed treatment options. A major barrier to developing effective therapies for LMD is the lack cell-based or preclinical models that recapitulate disease. Here, we describe development in vitro vivo cultures patient-derived cerebrospinal fluid circulating tumor cells (PD-CSF-CTCs) from patients with melanoma model identify exploitable vulnerabilities LMD. Methods...
Background Proinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME). In current study, we sought to investigate prognostic value TLS-associated (TLS-kines) expression levels in melanoma patients by performing serum protein tissue transcriptomic analyses, then correlate these data with clinicopathological TME characteristics. Methods Levels TLS-kines patients’ sera were quantitated using a custom...
Abstract Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP–SNP interactions in the four pathways (the angiogenesis-, mitochondria-, miRNA-, androgen metabolism-related pathways) associated with PCa aggressiveness, we tested 8587 SNPs 20,729 cases from consortium. We identified 3 KLK3 SNPs, 1083 ( P < 3.5 × 10 –9 )...
3009 Background: PD-1 antibodyNivolumab was administered with/without a multi-peptide vaccine to 105 patients (pts) with unresectable melanoma that failed at least one regimen and were IPI naïve, or progressed after IPI, assess its toxicity especially in those prior dose limiting immune related adverse events (irAEs) update survival data, characterize T cell gene expression subsets. Methods: HLA A0201 IPI-naïve pts received nivolumab 1, 3 10 mg/kg (34 pts); additional mg/kg: two cohorts of...
Although increasing evidence shows that immune infiltration plays an essential role in glioblastoma (GBM), current prognostic indicators do not accurately represent the risk of cells patients. It is therefore critical to identify new markers for GBM. Here, we investigated effectiveness using immunoscore improve stratification and prediction prognosis GBM patients receiving chemotherapy. Using mRNA microarrays CIBERSORT, analyzed 22 types cell fractions 517 samples characterized least...