A5046463509- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Diabetes and associated disorders
- Ubiquitin and proteasome pathways
- Chromosomal and Genetic Variations
- Antibiotic Resistance in Bacteria
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
- Clostridium difficile and Clostridium perfringens research
- Blood disorders and treatments
- Toxoplasma gondii Research Studies
- vaccines and immunoinformatics approaches
- Antibiotic Use and Resistance
Inserm
2014-2025
Université Grenoble Alpes
2014-2025
Centre National de la Recherche Scientifique
1994-2025
Institut pour l'avancée des biosciences
2010-2022
Institut de Biosciences et Biotechnologies
2019-2022
CNR de la Résistance aux Antibiotiques
2019
Sorbonne Université
1993-2017
Immunologie - Immunopathologie - Immunothérapie
2017
Pitié-Salpêtrière Hospital
2017
Bipar
2017
The International Nomenclature Committee for Staphylococcal Superantigens proposes an international procedure the designation of newly described superantigens and putative superantigens, a that will be compatible with new age genomics.
Multiple sclerosis-associated retroviral element (MSRV) is a element, the sequence of which served to define W family human endogenous retroviruses. MSRV viral particles display proinflammatory activities both in vitro mononuclear cell cultures and vivo humanized SCID mice model. To understand molecular basis such properties, we have investigated inflammatory potential surface unit envelope protein (ENV-SU), fraction that poised naturally interact with host cells. We report this study ENV-SU...
Abstract Human polymorphonuclear neutrophils, monocytes, and lymphocytes were studied for their ability to synthesize Paf-acether when stimulated with the ionophore A 23187 (Io) or specific secretagogues. When Io, neutrophils produced 100 +/- 8.5 pmol 1 X 10(6) cells (mean SD, n = 5); monocytes less efficient (44 3.3 Paf-acether/1 cells), whereas practically unable form this mediator (1.0 0.4 cells). Neutrophils released in extracellular medium 49 37% of that they formed, respectively. We...
Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system (CNS) for which animal models have mainly addressed downstream immunopathology but not potential inducers autoimmunity. In absence pathogen known to cause neuroinflammation in MS, Mycobacterial lysate commonly used form complete Freund's adjuvant induce autoimmunity myelin proteins Experimental Allergic Encephalomyelitis (EAE), an model MS. The present study demonstrates that protein from human...
Abstract Although quite a lot is known about the genetic structure of polytypic species Mus musculus at periphery its range, centre origin and dispersion remains unknown. To investigate amount subdivision that occurs in central parts we analysed variation four new samples mice coming from Iran, Pakistan, northern southern India using 35 autosomal protein loci restriction fragment length polymorphisms three genes Vβ gene complex immune system. The was then compared with found subspecies...
Understanding how hepatitis C virus (HCV) induces and circumvents the host's natural killer (NK) cell-mediated immunity is of critical importance in efforts to design effective therapeutics. We report here decreased expression NKG2D activating receptor as a novel strategy adopted by HCV evade NK-cell mediated responses. show that chronic infection associated with ligands for NKG2D, MHC class I-related Chain (MIC) molecules, on hepatocytes. However, downmodulated circulating NK cells,...
Building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet) was proposed to strengthen One Health antimicrobial resistance (AMR) surveillance approach.
Patients with chronic hepatitis B virus (HBV) infection are characterized by impaired immune response that fails to eliminate HBV. Immune checkpoint molecules (ICMs) control the amplitude of activation and function cells, which makes them key regulators response. We performed a multiparametric flow cytometry analysis ICMs determined their expression on intrahepatic lymphocyte subsets in untreated treated patients HBV comparison non-pathological liver tissue. The exhibited high accumulation...
Background: Hepatitis B is a liver infection caused by HBV. Infected individuals who fail to control the viral develop chronic hepatitis and are at risk of developing life-threatening diseases, such as cirrhosis or cancer. Dendritic cells (DCs) play important roles in immune response against HBV but functionally impaired patients with B. The underlying mechanisms involved HBV-induced DC dysfunctions remain be elucidated. Methods: We explored modulations HBsAg exposing blood-derived cDC1s,...
Knowledge of the complete nucleotide sequence mouse TCRAD locus allows an accurate determination V-J rearrangement status. Using multiplex genomic PCR assays and real time analysis, we report a comprehensive systematic analysis recombination TCR α chain in normal thymocytes during development. These respective qualitative quantitative approaches give rise to four major points describing control gene rearrangements. (a) The pattern is not random ontogeny generates limited repertoire; (b)...
We have characterized a panel of monoclonal antibodies (mAb) produced by immunizing rats with two distinct soluble mouse alpha/beta T cell receptor (TcR). Fifty mAb were found to react the corresponding surface-bound TcR. Such observations suggest that TcR molecules used as immunogen are folded in conformation similar native structure. Furthermore, binding cells four was correlate expression V alpha 8, beta 2 or 10 gene segments. Finally, staining lymphocytes from various strains suggests...
Abstract Background Chronic liver inflammation and immune/inflammatory response promote hepatocellular carcinoma. The aim of this study was to characterize the immune status HCV ‐related cirrhosis in patients with carcinoma ( ‐ HCC ) as compared without Method Immune markers CD 3, 4, 8, 20, 56, TCR γδ, FoxP3) gene expression profiles 8α, 8β, FoxP3, IL ‐6, IFN ‐γ, perforin, RANTES were analysed a test cohort by immunohistochemistry quantitative RT PCR analysis on serial non‐tumorous tumorous...